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NYU Langone Provider

Thomas M. Wisniewski, MD

NYU Langone Provider
  • Specialties: Neuropathology, Dementia & Alzheimer's
  • Treats: Adults
  • Language: English
  • Phone: 212-263-3210
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Caring for people who have Alzheimer’s disease and related types of dementia is a family tradition. One of my first childhood memories is helping my father, who was a renowned Alzheimer’s researcher and neuropathologist, conduct research. My mother was a pediatric neurologist who made significant contributions to the field. Their work inspired me to pursue a career in neurology and neuropathology.

As the director of the New York State Center of Excellence for Alzheimer’s Disease at the Pearl I. Barlow Center for Memory Evaluation and Treatment, I evaluate patients who have a variety of cognitive disorders. These include mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease dementia, dementia with Lewy bodies, frontotemporal dementia, and Creutzfeldt-Jakob disease.

My colleagues and I conduct research to better understand the genetics and progression of Alzheimer’s disease, so we are familiar with the latest advances in the field. To identify the cause of a person’s symptoms, I recommend neuroimaging, which involves performing a combined MRI and PET scan.

I prescribe medication and offer my patients access to clinical trials focused on new therapeutic approaches, which may include medication and lifestyle changes. At the Pearl I. Barlow Center for Memory Evaluation and Treatment, there are typically 8 to 10 clinical trials running at any given time.

Alzheimer’s disease and other cognitive disorders can be stressful for patients and their families, so my colleagues and I work as a team to meet their needs. Neurologists, psychologists, geriatricians, geriatric nurse practitioners, and social workers who specialize in geriatric care collaborate to support patients, caregivers, and family members.

NYU Langone’s Alzheimer’s Disease and Related Dementias Family Support Program provides counseling, support, and education for caregivers. The program partners with community support groups, such as the Alzheimer’s Association and CaringKind, to help patients and families.

I enjoy working with patients and their families and researching promising new therapies for Alzheimer’s disease. I am the director of NYU Langone’s Alzheimer’s Disease Research Center and its Center for Cognitive Neurology. For more than 30 years, I have been studying Alzheimer’s disease and related types of dementia, with continuous funding from the National Institutes of Health. This has led to more than 350 peer-reviewed publications and 30 U.S. patents. My work has contributed to the development of novel biomarkers and therapeutic approaches to Alzheimer’s disease. I am currently studying a medication that stimulates immune system cells to eliminate the brain lesions associated with Alzheimer’s disease.

I am the field chief editor of the journal Frontiers in Aging Neuroscience. In addition, I received the Alzheimer’s Association’s Zenith Fellows award, which funds innovative scientific research.

Conditions and Treatments

  • alzheimer's disease
  • cognitive disorder
  • cognitive impairment
  • creutzfeldt jakob disease
  • dementia
  • frontotemporal dementia
  • lewy body dementia
  • memory disorder
  • memory loss
  • prion disease

Board Certifications
  • American Board of Pathology (Neuropathology), 1990
  • American Board of Psychiatry & Neurology - Neurology, 1989
Education and Training
  • Fellowship, Columbia Presbyterian Medical Center, Neuropathology, 1990
  • Residency, NYU Medical Center, 1988
  • MD from University of London, 1983

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This provider accepts the following insurance plans.

  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna International
    • Aetna Medicare Advantage
    • Aetna Open Access EPO
    • Aetna Open Access HMO
    • Aetna POS
    • Aetna POS (American Express Employer)
    • Aetna PPO
    • Aetna Signature Administrators PPO
    • Aetna Student Plan
    • Allied
    • Chesterfield Resources Inc
    • Christian Brothers Services
    • CoreSource
    • Nippon Life of America-Aetna
    • Nippon Life-Aetna
    • Starmark
    • WellNet
  • Amida Care
    • Amida Care Medicaid
  • Anthem Blue Cross Blue Shield
    • Anthem BCBS CT PPO
    • Anthem BCBS CT Pathway PPO
    • BCBS Blue Access EPO Large Group
    • BCBS Blue Access EPO Small Group
    • BCBS Blue Access GEPO Small Group
    • BCBS Blue Access PPO Large Group
    • BCBS EPO
    • BCBS EPO (BlackRock Employees)
    • BCBS EPO (LICH Employees)
    • BCBS EPO - Empire EPO (NYU Langone Employees)
    • BCBS EPO - Empire EPO (Sunset Park/Family Health Center Employees)
    • BCBS EPO - Empire NYU Care (NYU Langone Employees)
    • BCBS EPO - Empire NYU Care (Sunset Park/Family Health Center Employees)
    • BCBS Federal Program
    • BCBS Florida Blue Care HMO
    • BCBS Florida Blue Medicare PPO
    • BCBS Florida Blue Options PPO
    • BCBS Florida Blue Select
    • BCBS Florida MyBlue HMO
    • BCBS Florida Simply Blue
    • BCBS Florida Traditional PPC
    • BCBS HMO
    • BCBS Indemnity
    • BCBS Local 32BJ Employees
    • BCBS Mediblue Medicare HMO
    • BCBS Mediblue Medicare PPO
    • BCBS Mediblue Select HMO/Extra HMO
    • BCBS POS
    • BCBS PPO
    • BCBS PPO (BlackRock Employees)
    • BCBS PPO (LICH Employees)
    • BCBS PPO - Empire PPO (Sunset Park/Family Health Center Employees)
    • BCBS PPO/EPO Small Group
    • New York Hotel Trades
  • Centerlight Healthcare
    • CenterLight Healthcare DIRECT
    • CenterLight Healthcare PACE
    • CenterLight Healthcare Select
    • Centerlight Pace Medicare HMO
  • Centers Plan For Healthy Living
    • Centers Plan For Healthy Living
    • Centers Plan For Healthy Living Medicaid Advantage Plus HMO D-SNP
  • Cigna
    • Apwu Health Plan
    • Cigna - Humana
    • Cigna Great West PPO
    • Cigna HMO
    • Cigna Indemnity
    • Cigna Managed Care/POS
    • Cigna Medicare Advantage
    • Cigna NALC
    • Cigna Open Access
    • Cigna Open Access PPO
    • Cigna Oscar
    • Cigna PPO
    • Cigna Premier Plus
    • Great West HMO
    • Kaiser Permanente
    • MVP-Cigna Network
    • Wellfleet-NYU Student
  • Connecticare
    • Connecticare Bridge
    • Connecticare Commercial
  • Elderplan
    • Elderplan
    • Elderplan FIDA
    • Elderplan Medicare Advantage Plan
  • Emblem
    • Emblem Select Care Bronze Small Group
    • Emblem Select Care EPO
    • Emblem Select Care Gold Small Group
    • Emblem Select Care HMO
    • Emblem Select Care PPO
    • Emblem Select Care Platinum Small Group
    • Emblem Select Care Silver Small Group
  • GHI
    • American Plan Administrators
    • GHI CBP (City of New York Employees)
    • GHI Emblem Health EPO
    • GHI Emblem Health PPO
    • GHI HMO
    • GHI HMO Medicare
    • GHI Medicare PPO
    • GHI Medicare Supplement
    • GHI Network Access - Benefit Services of PA
    • GHI Network Access - Humana
    • GHI Network Access - Total Plan Concepts
    • IUOE Local 14-14B
    • Wlny-TV Inc.
  • HIP
    • HIP Access I
    • HIP Access II
    • HIP Bridge
    • HIP Child Health Plus
    • HIP EPO
    • HIP HMO
    • HIP Medicare Supplement
    • HIP POS
    • HIP PPO
    • HIP Prime Basic Exchange
    • HIP Prime Bronze
    • HIP Prime Bronze Exchange
    • HIP Prime Catastrophic Exchange
    • HIP Prime Gold
    • HIP Prime Gold Exchange
    • HIP Prime Platinum
    • HIP Prime Platinum Exchange
    • HIP Prime Silver
    • HIP Prime Silver Exchange
    • HIP VIP Medicare Bold
    • HIP VIP Medicare Prime
    • Vytra HMO
  • Humana
    • Humana Medicare Advantage
  • Local 1199
    • Local 1199 - NYU Hospital Member Choice
    • Local 1199 PPO
  • Magnacare
    • Magnacare PPO
  • Medicare
    • Medicare Part A and B
    • Medicare Part B
  • Multiplan
    • AXA Assistance USA
    • Administrative Concepts
    • Beech Street PPO
    • Diversified Administration Corporation
    • Fiserv Health
    • GEHA
    • Global Excel
    • Global Health
    • Guardian Life Insurance Co Of America
    • Health Net Of California
    • Health Republic Of NJ
    • Humana Health Plan
    • Insurance Design Administrators
    • Kaiser Foundation
    • Kaiser Permanente
    • Meritain Health
    • Multiplan PPO
    • Multiplan-Capital Dist Phys Health
    • Mutual Of Omaha
    • Nippon Life Ins Co
    • PHCS
    • Professional Benefit Admin
    • Qualcare Inc
    • Screen Actors Guild
    • Teamsters Allied Benefits
    • US Life Insurance Company
  • NYSHIP - The Empire Plan
    • NYS Health Insurance Plan - The Empire Plan, Excelsior Plan, NY Student Employee Health Plan
  • Oxford
    • Oxford Health Plans Freedom
    • Oxford Health Plans Liberty
  • POMCO Insurance Company
    • POMCO Insurance Company
  • Qualcare Inc.
    • Qualcare Direct
  • Railroad Medicare
    • Palmetto GBA Railroad Medicare
  • River Spring Health Plan
    • River Spring Medicare HMP SNP
  • Sedgwick WTC
    • World Trade Center - Sedgwick
  • United Healthcare
    • AARP Medicare Complete
    • Bind Benefits inc
    • Oxford Health Plans Medicare Advantage
    • UMR
    • Unite Healthcare (NY University Care Plan)
    • United Healthcare AARP
    • United Healthcare All Savers
    • United Healthcare Choice
    • United Healthcare Choice (AMEX employees)
    • United Healthcare Choice (Blackrock employees)
    • United Healthcare Choice (CBS employees)
    • United Healthcare Choice (Simon
    • United Healthcare EPO
    • United Healthcare EPO (NYU Langone Health Employees)
    • United Healthcare Golden Rule Insurance
    • United Healthcare HMO
    • United Healthcare Indemnity
    • United Healthcare Indemnity (NYU Langone Health Employees)
    • United Healthcare Medicare
    • United Healthcare Navigate
    • United Healthcare Nexus
    • United Healthcare Nexus (Amex Employees)
    • United Healthcare POS
    • United Healthcare PPO
    • United Healthcare Plus (NYU Langone Health Employees)
    • United Healthcare Student Resources
    • United Healthcare Student Resources (NYU)
    • United Healthcare Value, Advantage and HDHP (New York University employees)
    • UnitedHealthcare Choice (NY Power Authority Employees)
  • VA Community Care Network
    • VA CCN Optum
  • VNS Choice Advantage
    • VNS Medicare Advantage
    • VNS NY Choice Select Health
  • WTC Health Program
    • NY Fire Department - WTC
    • WTC Health Program
View All Accepted Plans This list of insurances changes regularly, and insurance plans listed may not be accepted at all office locations for this provider. Before your appointment, please confirm with your insurance company that this provider accepts your insurance.

Thomas M. Wisniewski, MD does not accept insurance.

Locations and Appointments

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Pearl I. Barlow Center for Memory Evaluation & Treatment

145 East 32nd Street, 2nd Floor, New York, NY 10016


immunology, neuropathology, neuroscience, Alzheimer's disease, prion diseases, immunomodulation

Research Summary

I am a board-certified neurologist and neuropathologist, and I run an active research laboratory focusing on neurodegenerative disorders—with a particular focus on the mechanisms that drive amyloid deposition in Alzheimer’s and prion diseases. This work has led to over 300 peer-reviewed publications, 28 issued patents, and continuous funding from the NIH for over 30 years.

My lab has made key discoveries in gaining a greater understanding of possible therapeutic interventions, including discovering the role of apolipoprotein E (APOE) in driving amyloid deposition in late-onset Alzheimer’s disease. I coined the term “pathological chaperone” to denote the role of APOE, even before the discovery of the link between the APOE E4 allele and late-onset Alzheimer’s disease. More recently, my laboratory developed a novel therapeutic approach based on blocking the interactions between apoE and amyloid β, showing it to be effective in multiple Alzheimer's disease models.

My lab also develops strategies for the enhanced clearance of pathological conformations of both amyloid beta and tau proteins in Alzheimer’s disease, using both active and passive immunization approaches—specifically through targeting toxic oligomeric species as well as through the stimulation of innate immunity via agonists of Toll-like receptor 9. These approaches have been highly efficacious in several rodent and non-human primate models of Alzheimer’s and prion diseases.

We tested these immunomodulation approaches for a broader list of neurodegenerative diseases, called conformational diseases. Our approaches delay the onset of disease in animal models of prion infection. Recent studies have focused on testing a novel mucosal vaccine in white-tailed deer to prevent chronic wasting disease, an emerging, highly infectious prion disease affecting large numbers of cervids  in the United States, Canada, and recently in northern Europe. Our data suggest that mucosal vaccination can confer partial protection from the prion agent, representing the first partially effective treatment for naturally occurring prion disease.

Recently my laboratory has developed an unbiased localized proteomic methodology that produces robust data utilizing archival formalin, fixed paraffin embedded human tissue, and used this method to perform the most extensive proteomic analyses of amyloid plaques and phosphorylated tau in Alzheimer's disease patient tissue.

I obtained my MD at King’s College London GKT School of Medical Education. I completed my residencies and chief residencies in neurology and neuropathology at NYU School of Medicine and New York-Presbyterian/Columbia University Medical Center, respectively.

Academic Contact

Academic office

435 East 30th Street

10th Floor, Room 1017

New York, NY 10016



These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

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View All Research Studies (10)

Read All Publications (534)

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