Inflammatory Disease Genetics Program

At NYU Langone’s Inflammatory Disease Genetics Program, geneticists, rheumatologists, and certified genetic counselors on our team care for adults and children with inflammatory conditions whose symptoms are severe or whose cause is unknown.

We use both genetic testing and research-based analysis to identify the underlying genetic causes of these conditions. Using this information, we work to provide the most-advanced targeted therapies, counseling about how the condition may develop and change over time, and risk assessment for other family members.

Our team specializes in two types of conditions. Autoimmune conditions occur when the body’s immune system targets healthy tissues by mistake and attacks them. Autoinflammatory conditions cause symptoms when there are no other signs of infection. These include the following:

• VEXAS syndrome, a rare but serious condition that can cause unexplained symptoms throughout the body such as fever and fatigue, painful skin rashes, pain and swelling of the ears and nose, coughing or shortness of breath, and vasculitis, among others
• periodic fever syndromes, which are conditions that cause recurring fevers not caused by an infection
• severe, unexplained inflammation that causes symptoms in the bone marrow, lungs, cartilage, or skin

Our team is part of NYU Langone’s renowned Center for Human Genetics and Genomics at NYU Grossman School of Medicine. The center’s research goal is to discover new genetic causes of rheumatological disease. To that end we work closely with rheumatologists to coordinate improved care for people who are struggling for answers.