I was born in Brooklyn, and although I lived elsewhere during college and residency training, I consider myself a lifelong New Yorker. While getting my MD and PhD in molecular pharmacology from Albert Einstein College of Medicine in the Bronx, I realized I was especially fascinated by the field of dermatology. I loved taking care of children when I rotated through pediatrics as a medical student, so I chose to combine these interests and specialize in pediatric and adolescent dermatology.
I arrived at NYU Langone in 1990, joining one of the leading dermatology departments in the world. Whether treating a newborn or a college student, I want to do everything I can to help my patients and to support their families, while always balancing the benefits and risks of a particular treatment.
In my research, I have worked to determine the risks associated with certain birthmarks and skin growths, such as hemangiomas, and have collaborated with molecular geneticists to identify genetic changes that cause congenital skin conditions. I’ve also worked to improve how we treat eczema and psoriasis in children and teenagers. In 2003, I received a Lifetime Achievement Award from the American Skin Association.
Conditions and Treatments
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- Samuel Weinberg Professor of Pediatric Dermatology, Ronald O. Perelman Department of Dermatology
- Professor, Department of Cell Biology
- Professor, Department of Pediatrics
- Chair, Ronald O. Perelman Department of Dermatology
- Director, Program in Cutaneous Biology
- American Board of Dermatology (Pediatric Dermatology), 2004
- American Board of Dermatology - Dermatology, 1990
Education and Training
- Fellowship, Yale - New Haven Medical Center, Pediatric Dermatology, 1990
- Residency, Yale - New Haven Medical Center, Dermatology, 1989
- MD from Albert Einstein College of Med, 1986
- PhD from Albert Einstein College of Med, 1986
Locations and Appointments
- WTC Health Program-HHC
- WTC Health Program-Mt.Sinai
- WTC Health Program—NYU
- WTC Health Program—North Shore
- WTC Health Program—Stonybrook
- WTC Health Program—UMDNY/Rutgers
- WTC Health Program—North Shore
- United Health Care Options PPO (NYU Langone Health Employees)
- United Healthcare Choice (NYU Langone Health Employees)
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“My research has improved treatments for eczema and psoriasis in children and teenagers.”Seth J. Orlow, PhD, MD Pediatric Dermatologist
Research My Research
development of novel targeted therapies in melanoma and other cancers, molecular and cellular basis of pigmentation, cancer, pharmacology
1. Development of novel therapeutics for the treatment of a number of cancers including melanoma and multiple myeloma, as well as unraveling pathways underlying chemoresistance in these tumors. To do so, we utilize small molecule screening of already-approved drugs ("drug repositioning") and of natural products combined with molecular and cellular techniques. 2. Understanding the cell biology of melanin synthesis and deposition in the skin, hair and eyes, including the processing and trafficking of tyrosinase, the rate-limiting enzyme in melanin production, as well as the pathogenesis of various forms of oculocutaneous albinism that diminish pigmentation. 3. Elucidating the pathogenesis of vitiligo, in which melanocytes in the skin are destroyed, including the role of endoplasmic reticulum stress and the unfolded protein response.
Research Interests Timeline
Journal of the American Academy of Dermatology. 2018 Jun 24; 78(6):1232-1235
Journal of the American Academy of Dermatology. 2018 Jun 14; 78(6):1209-1211
American journal of clinical dermatology. 2018 Jun; 19(3):449-455