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Edward A. Fisher, MD, PhD, MPH

  • Specialties: Preventive Cardiology, Cardiology
  • Language: English

Credentials

Positions
  • Leon H. Charney Professor of Cardiovascular Medicine, Department of Medicine
  • Professor, Department of Pediatrics
  • Professor, Department of Cell Biology
  • Professor, Department of Microbiology
Board Certifications
  • American Board of Pediatrics - Pediatrics, 1981
Education and Training
  • Fellowship, NA, Medical Genetics, 1984
  • Fellowship, Boston Children's Hospital, Gasteoenterology, 1982
  • PhD from Massachusetts Inst of Tech, 1982
  • MPH from University of NC - Chapel Hill, 1978
  • Residency, Duke University Hospital, Pediatric Medicine, 1977
  • MD from New York University, 1975

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Insurance Plans Accepted

This provider accepts the following insurance plans.

  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna Medicare
    • Aetna POS
    • Aetna PPO/EPO
  • Cigna
    • Cigna EPO/POS
    • Cigna PPO
  • Emblem
    • Emblem Select Care Exchange
  • Empire Blue Cross Blue Shield
    • Empire Blue Cross Blue Shield EPO
    • Empire Blue Cross Blue Shield HMO
    • Empire Blue Cross Blue Shield HealthPlus
    • Empire Blue Cross Blue Shield HealthPlus Essential
    • Empire Blue Cross Blue Shield Indemnity
    • Empire Blue Cross Blue Shield MediBlue
    • Empire Blue Cross Blue Shield POS
    • Empire Blue Cross Blue Shield PPO
    • Empire Blue Cross Blue Shield Pathways, Enhanced
  • GHI
    • GHI CBP
    • GHI HMO
  • HIP
    • HIP Access I
    • HIP Access II
    • HIP Child Health
    • HIP EPO/PPO
    • HIP Essential
    • HIP HMO
    • HIP Medicaid
    • HIP Medicare
    • HIP POS
  • HealthSmart
    • HealthSmart (WTC)
View All Accepted Plans This list of insurances changes regularly, and insurance plans listed may not be accepted at all office locations for this provider. Before your appointment, please confirm with your insurance company that this provider accepts your insurance.

Research My Research

Interests

lipoprotein metabolism, atherosclerosis

Research Summary

My laboratory is involved in two major themes of research: 1. The cell biology of hepatic lipid and lipoprotein metabolism: Atherogenic lipoproteins contain apoprotein B (apoB) and cholesteryl esters. The net production of apoB is determined not at the level of synthesis, but at the level of intracellular, pre-secretory, degradation. My lab has been the first to demonstrate a non-proteasomal pathway of apoB degradation regulated by dietary fatty acids, a process that may also be regulated by insulin. Importantly, this non-proteasomal pathway may be dysregulated in insulin-resistance (such as seen in adults, and, unfortunately, a growing number of adolescents, with type II diabetes or obesity) and, thereby, contribute to the over-production of atherogenic lipoproteins that increase the risk of coronary artery disease in these metabolic states. To further pursue the proteasomal and non-proteasomal regulation of apoB degradation, my laboratory is using cell and molecular biological approaches on experimental models as diverse as cell-free systems and tissue-specific knockout mice. 2. The molecular biology of vascular diseases. My laboratory is also interested in the molecular factors that regulate the progression and regression of atherosclerotic plaques, a disease process now known to begin in childhood. This research relies on mouse models of atherosclerosis and current projects focus on: the regression of plaques after the normalization of hyperlipidemia; the effects of HDL on plaque progression and regression; To get at the molecular levels that regulate changes induced by the various experimental conditions in specific arterial wall cell types, his laboratory has pioneered the use of laser capture microdissection to isolate plaque macrophages in order to study gene expression. Recently, by using novel mouse models developed by us and our collaborators and these powerful techniques, my laboratory has published reports that foam cells can leave plaques during regression and they require dendritic cell properties for this emigration. We also have an active collaboration in the imaging of atherosclerosis in living mice. With Dr. Zahi Fayad at Mount Sinai, we have recently shown that HDL particles can be converted to nanoplatforms to deliver MRI enhancing agents to plaques to better visulaize them. Our goal is to adapt these particles for molecular imaging purposes.

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Publications

  • Barrett, Tessa J; Distel, Emilie; Murphy, Andrew J; Hu, Jiyuan; Garshick, Michael S; Ogando, Yoscar; Liu, Jianhua; Vaisar, Tomas; Heinecke, Jay W; Berger, Jeffrey S; Goldberg, Ira J; Fisher, Edward A

    Circulation. 2019 Oct ; 140(14):1170-1184

  • Chang, Hye Rim; Josefs, Tatjana; Scerbo, Diego; Gumaste, Namrata; Hu, Yunying; Huggins, Lesley-Ann; Barett, Tessa; Chiang, Stephanie; Grossman, Jennifer; Bagdasarov, Svetlana; Fisher, Edward A; Goldberg, Ira J

    Arteriosclerosis, thrombosis, & vascular biology. 2019 Aug 22; ATVBAHA119312389

  • Binderup, Tina; Duivenvoorden, Raphaël; Fay, Francois; van Leent, Mandy M T; Malkus, Joost; Baxter, Samantha; Ishino, Seigo; Zhao, Yiming; Sanchez-Gaytan, Brenda; Teunissen, Abraham J P; Frederico, Yohana C A; Tang, Jun; Carlucci, Giuseppe; Lyashchenko, Serge; Calcagno, Claudia; Karakatsanis, Nicolas; Soultanidis, Georgios; Senders, Max L; Robson, Philip M; Mani, Venkatesh; Ramachandran, Sarayu; Lobatto, Mark E; Hutten, Barbara A; Granada, Juan F; Reiner, Thomas; Swirski, Filip K; Nahrendorf, Matthias; Kjaer, Andreas; Fisher, Edward A; Fayad, Zahi A; Pérez-Medina, Carlos; Mulder, Willem J M

    Science translational medicine. 2019 08 21; 11(506):

Read All Publications (287)

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