Medication for Osteomyelitis

NYU Langone orthopedic surgeons and infectious disease specialists work together to identify the bacteria or other germs responsible for a bone infection, known as osteomyelitis. Using this information, they create a treatment plan. They typically prescribe oral or intravenous (IV) antibiotics.

Some antibiotics work best if they are delivered through an IV, whereas others are most effective when taken by mouth. These medications can cause side effects such as nausea, upset stomach, and diarrhea.

IV antibiotics are administered at an infusion center or in your home. In the hospital or during a doctor’s office visit, an interventional radiologist will place a device called a peripherally inserted central catheter, also called a PICC line or a mediport, under your skin. This small appliance allows you to receive IV medications more easily. A home healthcare provider can visit your home to teach you or a caregiver how to administer the antibiotics yourself or arrange for a visiting nurse to give you the medication.

Some antibiotics are given once or twice a day, whereas others may be given several times a day for a shorter period.