Seth D. Cohen, MD, MPH

Memorial Sloan Kettering Cancer Center - Department of Urology 
Research Project, July 2010 – October 2010 
We conducted a retrospective chart review evaluating survival outcomes in patients with positive renal tumor thrombus margins and negative renal tumor thrombus margins after surgical treatment of pT3bN0M0 tumors. This study demonstrated that right-sided laterality, increased EBL, and increased pathological tumor size were associated with poorer overall survival but a positive renal tumor thrombus margin was not. K2

Albany College of Pharmacy, Albany Medical College - Department of Urology 
Research Project, July2010 – October 2010 
We determined in vivo and in vitro whether oral pretreatment of rabbits with Kohki tea (Japanese Tea with strong antioxidants) protects the bladder from dysfunction induced by partial outlet obstruction. The study determined that Kohki tea had a significant protective effect on bladder function, contractile responses and bladder biochemistry in rabbits with moderate to severe partial outlet obstruction.

Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine - Department of Urology 
Research Project, June 2000 – August 2000 
We assessed the ability of adenovirus mediated expression of the Escherichia coli cytosine deaminase gene in conjunction with the prodrug 5-fluorocytosine to result in radiation sensitization in the mouse prostate cancer cell line RM-1 in vitro. The study demonstrated that the combination of adenovirus mediated cytosine deaminase plus 5-fluorocytosine and radiation therapy resulted in radiation sensitization, suggesting a potential usefulness of this treatment in patients with prostate cancer.