William L. Carroll, MD

  • Specialty: Pediatric Hematology—Oncology
  • Language: English
  • Phone: 212-263-9906
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About Me

At NYU Langone’s Stephen D. Hassenfeld Children’s Center for Cancer and Blood Disorders, I treat children who have pediatric malignancies, such as leukemia and lymphoma. My personal philosophy and our team’s goal is to provide individualized treatment that fits each child.

We don’t just treat patients—we care for children and their families. We use a 360-degree approach that extends beyond medical treatment, aiming to improve diet and nutrition and reduce the psychological, social, and spiritual burden of illness. The cure rate for childhood cancers has improved dramatically, but we want children and their families to continue to live their lives as healthfully as possible, so we focus on the future from the first day of treatment.

As an oncologist involved in several national committees, I have an appreciation of where oncology is headed and how it has changed. I perform research that is funded by the National Cancer Institute and focused on discovering the molecular origins of childhood cancers. I use this research to develop better treatments and, someday, preventive measures. We are also developing precision medicine, in which we use the genetic makeup of a tumor to understand its vulnerabilities.


Conditions and Treatments

leukemia, lymphoma, blood disorder, anemia, platelet disorder, pancytopenia, stem cell transplantation, soft tissue sarcoma, male germ cell tumor, AIDS-related lymphoma, neuroblastoma, acute myelogenous leukemia, kidney cancer, blood cancer, acute lymphoblastic leukemia, Hodgkin lymphoma, bone cancer, bone sarcoma, bone tumor, Wilms tumor, renal cell carcinoma
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Credentials

Positions
  • Julie and Edward J. Minskoff Professor of Pediatrics, Department of Pediatrics
  • Professor, Department of Pathology
  • Associate Chair for Clinical and Translational Research, Department of Pediatrics
Board Certifications
  • American Board of Pediatrics (Pediatric Hematology-Oncology), 1987
  • American Board of Pediatrics - Pediatrics, 1984
Education and Training
  • Fellowship, Stanford University Hospital, Hematology Oncology, 1987
  • Fellowship, Stanford University Hospital, Peds Hem/Oncology, 1984
  • Residency, Children's Hospital Medical Center, Pediatrics, 1982
  • MD from University Of California, 1978
Departments

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Stephen D. Hassenfeld Childrens Center for Cancer & Blood Disorders

160 East 32nd Street, 3rd Floor
New York, NY 10016

Research My Research

Interests

cancer, pharmacology, childhood cancers, acute leukemia, apoptotic pathways in cancer cells, genomic and epigenomic analysis of childhood cancer, relapsed/resistant leukemia

Research Summary

In our laboratory we focus on two major challenges facing children with acute lymphoblastic leukemia (ALL). First, in spite of dramatic improvements in outcome, one in five children will suffer a relapse and then have a poor prognosis. Second, the physical and emotional costs of therapy for those who are cured are high, with short- and long-term side effects.

Therefore, we seek to understand mechanisms of drug resistance and to identify pathways unique to the cancer cell that can serve as targets for more effective, less toxic therapeutic approaches.

We use modern genomic and epigenomic methods to understand the genesis and evolution of ALL that leads to treatment failure. We have shown that resistant cancer cells acquire novel mutations that are responsible for drug resistance. In some cases, a small clone emerges through the selective effect of chemotherapy in a model reminiscent of Darwinian evolution. However, in other cases, such mutations may have been acquired during the course of treatment. Through years of effort we have created a “genetic fingerprint” of resistant cells and have used this information to pilot novel methods to prevent and treat relapse.

Most recently we have focused on the epigenome—molecular mechanisms that control gene activity that are not related to the DNA sequence itself. We have shown that DNA modifications, including methylation and histone changes, also allow the cancer cell to overcome therapy. The availability of new agents that target these epigenetic changes may allow for more effective treatment of relapsed disease and we are exploring this approach in laboratory models.

Our laboratory encompasses the full spectrum of investigation involving basic bench research, highly translational efforts using samples from patients, and clinical trials in children with ALL.

 

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Clinical Trials and Research Studies

  • Phase I-II Study of MEK 162 for Children with Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors

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  • AALL15P1 A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (IND# 133688 NSC# 102816) to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement

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  • AAML1531 Risk-stratified Therapy for Acute Myeloid Leukemia in Down Syndrome

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View All Research Studies (11)

Publications

Read All Publications (245)

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