Mohammad Maher Abdul Hay, MD

  • Specialties: Hematology, Bone Marrow Transplant
  • Language: English
  • Phone: 646-501-4818
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About Me

I have always been fascinated with medicine, and I have a strong commitment to providing clinical care and teaching. I chose to specialize in hematology and oncology because of the incredible breadth of the field, which motivated me to learn as much as possible to help people who have cancer.

At NYU Langone, we provide outstanding hematological care. In addition to conventional treatments, we offer novel treatments through our numerous clinical trials in acute leukemias and myelomas. I am blessed to work with talented doctors and nurses at Perlmutter Cancer Center. My team and I care for people with compassion, so that they can lead healthy lives with their loved ones.

I am also heavily involved in translational research, which focuses on translating research into patient care. When I was completing my postdoctoral research fellowship at the University of Illinois at Chicago before joining NYU Langone for my hematology and medical oncology fellowship, I came to realize how essential translational research is to improving care for people who have cancer. It plays a pivotal role in revealing the hidden mechanisms of complex hematological and oncological diseases, allowing us to develop successful treatments.

In addition to participating in research, I conduct clinical trials to provide novel medications for patients. I am also an active faculty member at NYU School of Medicine. For three years in a row, I was recognized as “Teacher of the Year” in the hematology program.


Conditions and Treatments

leukemia, bone marrow transplant, multiple myeloma, non-Hodgkin lymphoma, cutaneous T-cell lymphoma, AIDS-related lymphoma, anemia, platelet disorder, bleeding tendency, hematologic malignancies, acute myelogenous leukemia, blood cancer, myeloproliferative disorder, acute lymphoblastic leukemia, chronic myelogenous leukemia
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Credentials

Positions
  • Assistant Professor, Department of Medicine
  • Associate Director for Research, Bellevue Cancer Center
Board Certifications
  • American Board of Internal Medicine (Hematology), 2012
  • American Board of Internal Medicine (Medical Oncology), 2012
  • American Board of Internal Medicine - Internal Medicine, 2009
Education and Training
  • Fellowship, NYU School of Medicine, Hematology/Oncology, 2012
  • Residency, State University of NY at Buffalo, Internal Medicine, 2009
  • MD from American University - Beirut, 2004
Departments

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NYU Medical Oncology Associates

240 East 38th Street, 19th Floor
New York, NY 10016

Research My Research

Interests

AML, MPD, STAT3, targeted treatments, multiple myeloma, acute myeloid leukemia, myeloproliferative disorder, signal transducer and activator of transcription protein 3

Research Summary

STAT3 contributes to several aspects of the malignant phenotype, including increased cell survival and proliferation and decreased host anti-tumor immunity in the tumor microenvironment. Up to 50% of AML patients display enhanced tyrosine phosphorylation of STAT3 and high expression levels of STAT3 correlate with poor treatment response in these patients. Also serine phosphorylation of STAT proteins in the absence of tyrosine phosphorylation and increased cytokine signaling has been implicated in human leukemia. We have been conducting experiments to better understand the role of STAT3 serine phosphorylation, the novel role of mitochondrial STAT3, STAT3 metabolic programing and its effect on glutathione (GSH) production. In addition we are testing STAT3 expression in myeloblasts obtained from AML patients and its cytogenetics/molecular correlations. Our target have been to aid in the design of cancer therapeutics that target STAT3 dependent processes and so far we have found enhanced Romidepsin (HDAC inhibitor) toxicity in STAT3-contiaining cancer cells and continue to test the involvement of regulated GSH synthesis in this process. We are in the process of exploring novel agents that target STAT3 in multiple hematological malignancies like multiple myeloma. Our studies hopefully will lead to have better treatments available in hematological malignancies through targeting STAT3.

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Clinical Trials and Research Studies

  • A Phase Ib/IIa Study Evaluating the Safety and Tolerability of Vitamin C in Patients with Intermediate or high Risk Myelodysplastic Syndrome with TET2 Mutations

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  • Phase I Study of MK-3475 (Pembrolizumab) in Patients with Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant Neoplasm

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  • A Phase 1 Study Evaluating Safety Tolerability and Pharmacokinetics of Escalating Doses of AGS62P1 Given as Monotherapy in Subjects with Acute Myeloid Leukemia (AML)

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View All Research Studies (28)

Publications

Read All Publications (10)