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Affiliated Provider
Affiliated providers provide medical care at an NYU Langone location or a private practice, and are not employed by NYU Langone Health.

Mary Lynn R. Nierodzik, MD

Affiliated Provider
Affiliated providers provide medical care at an NYU Langone location or a private practice, and are not employed by NYU Langone Health.
  • Specialties: Medical Oncology, Hematology
  • Treats: Adults
  • Language: English
  • Phone: 212-263-3212
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I was born and raised in New York City, so I have always had an appreciation for NYU Langone and NYC Health + Hospitals/Bellevue. In addition to providing care for people who have cancer, I am a breast cancer survivor and was treated at NYU Langone. Because of my experiences, I have a better understanding of how to meet my patients’ needs.

As a hematologist and oncologist, I provide care to people who have cancers of the blood, including leukemia, lymphoma, and myelodysplastic syndromes (MDS). In 2004, I became the director of the Bellevue Cancer Center and was tasked with overseeing medical and surgical oncology at Bellevue, while providing seamless referral services for radiation oncology, bone marrow transplants, and genetic counseling to Perlmutter Cancer Center.

Additionally, I helped develop a multilingual patient navigation program and educational programs for patients and caregivers in English, Spanish, and Mandarin. I also helped initiate community outreach efforts, as well as interactive clinics and meetings that allow for collaboration between different specialties.

I believe that good care requires a strong partnership between patients and physicians. I aim to provide curative and palliative treatments that are in keeping with people’s own goals of care, always respecting their cultural and religious beliefs. Additionally, I participate in clinical trials so that my patients have access to new therapies.

I am a fellow of the American College of Physicians, American Society of Hematology, American Society of Clinical Oncology, and the International Society on Thrombosis and Haemostasis. I am also the recipient of NYU School of Medicine’s hematology and oncology teaching award.


Conditions and Treatments

Positions
Board Certifications
  • American Board of Internal Medicine (Hospice & Palliative Medicine), 2012
  • American Board of Internal Medicine (Hematology), 1988
  • American Board of Internal Medicine - Internal Medicine, 1985
Education and Training
  • Fellowship, New York University School of Medicine, Hematology-Oncology, 1990
  • Residency, SUNY Health Science Center, Medicine, 1986
  • MD from SUNY-Downstate, 1982

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Locations and Appointments

Bellevue Hospital Center

550 First Avenue, Building C&D - Room 556, New York, NY 10016

Interests

biomolecular significance of thrombin receptors on tumor cells, hematologic malignancies, health care disparaties, outcomes research

Research Summary

Metastatic cancer is associated with a hypercoagulable state; tumor cells can generate thrombin on their surface. We study the biomolecular significance of thrombin receptors on tumor cells. Platelets are required for metastasis in vivo. We showed that treating platelets with thrombin enhanced the adhesion of naive tumor cells to platelets. Active thrombin was necessary on the platelet surface. Thrombin administration with murine tumor cells enhanced pulmonary metastasis via a tail-vein injection in syngeneic mice. The platelet GPIIb-lIla adhesive ligand receptor was important for platelet-tumor cell interaction in vitro and metastasis in vivo.

A unique seven-membrane spanning thrombin receptor was cloned by Vu and colleagues in 1991 which requires proteolysis to produce a tethered ligand capable of activating the thrombin receptor. The thrombin receptor activation peptide (TRAP) from the tethered end recapitulated the thrombin effect on transfected xenopus oocytes and human platelets. We demonstrated the presence of the cloned receptor by RT-PCR in human and murine tumor cells lines and human tumor samples. Thrombin or TRAP treatment of tumor cells supported enhanced adhesion to platelets and increased murine metastasis in syngeneic mice
Currrently were are developing clinical trials to assess the use of antithrombin agents as adjuvants to chemotherapy.

These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

  • Phase II Trial of Radium-223 Dichloride in Combination with Paclitaxel in Patients with Bone Metastatic Breast Cancer

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  • A Phase 1b Multicenter Study to Determine the Dose Safety Efficacy and Pharmacokinetics of TRK-950 when Used in Combinations with Selected Anti-Cancer Treatment Regimens in Patients with Selected Advanced Solid Tumors.

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  • A Phase 2 Randomized Double-blind Study of Relatlimab plus Nivolumab in Combination with Chemotherapy vs. Nivolumab in Combination with Chemotherapy as First Line Treatment for Participants with Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

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View All Research Studies (12)

Read All Publications (24)