About Me
I was born and raised in New York City, so I have always had an appreciation for NYU Langone and NYC Health + Hospitals/Bellevue. In addition to providing care for people who have cancer, I am a breast cancer survivor and was treated at NYU Langone. Because of my experiences, I have a better understanding of how to meet my patients’ needs.
As a hematologist and oncologist, I provide care to people who have cancers of the blood, including leukemia, lymphoma, and myelodysplastic syndromes (MDS). In 2004, I became the director of the Bellevue Cancer Center and was tasked with overseeing medical and surgical oncology at Bellevue, while providing seamless referral services for radiation oncology, bone marrow transplants, and genetic counseling to Perlmutter Cancer Center.
Additionally, I helped develop a multilingual patient navigation program and educational programs for patients and caregivers in English, Spanish, and Mandarin. I also helped initiate community outreach efforts, as well as interactive clinics and meetings that allow for collaboration between different specialties.
I believe that good care requires a strong partnership between patients and physicians. I aim to provide curative and palliative treatments that are in keeping with people’s own goals of care, always respecting their cultural and religious beliefs. Additionally, I participate in clinical trials so that my patients have access to new therapies.
I am a fellow of the American College of Physicians, American Society of Hematology, American Society of Clinical Oncology, and the International Society on Thrombosis and Haemostasis. I am also the recipient of NYU School of Medicine’s hematology and oncology teaching award.
Conditions and Treatments
Conditions
- acute lymphoblastic leukemia
- acute myelogenous leukemia
- aids-related lymphoma
- aids-related malignancies
- anemia
- bleeding tendency
- blood cancer
- breast cancer
- cancer
- central nervous system lymphoma
- chronic lymphocytic leukemia (cll)
- chronic myelogenous leukemia (cml)
- cutaneous lymphoma
- cutaneous t-cell lymphoma
- essential thrombocythemia (et)
- hairy cell leukemia
- hematologic malignancies
- hodgkin lymphoma
- kaposi sarcoma
- leukemia
- lymphoma
- multiple myeloma
- myelodysplastic syndromes (mds)
- myeloproliferative disorder
- non-hodgkin lymphoma
- platelet disorder
- polycythemia vera
- thrombosis
Treatments
- stem cell transplant
Learn more about conditions we treat at NYU Langone:
Acute Lymphoblastic Leukemia , Leukemia , Acute Myeloid Leukemia , AIDS-Related Lymphoma , Chronic Lymphocytic Leukemia , Chronic Myelogenous Leukemia , Cutaneous T-Cell Lymphoma , Hairy Cell Leukemia , Myelodysplastic Syndromes , Myeloproliferative Disorders , Non-Hodgkin Lymphoma , Breast Cancer , Male Breast Cancer , Primary Central Nervous System Lymphoma , Hodgkin Lymphoma , Kaposi Sarcoma , Multiple MyelomaCredentials
Positions
- Clinical Assistant Professor, Department of Medicine at NYU Grossman School of Medicine
Board Certifications
- American Board of Internal Medicine (Hematology), 1988
- American Board of Internal Medicine - Internal Medicine, 1985
Education and Training
- Fellowship, New York University School of Medicine, Hematology-Oncology, 1990
- Residency, SUNY Health Science Center, Medicine, 1986
- MD from SUNY-Downstate, 1982
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Edit profileInsurance Plans Accepted
Please call the office for information about accepted insurance plans.
Mary Lynn R. Nierodzik, MD does not accept insurance.
Locations and Appointments
Bellevue Hospital Center
550 First Avenue, Building C&D - Room 556, New York, NY 10016
Research My Research
Interests
biomolecular significance of thrombin receptors on tumor cells, hematologic malignancies, health care disparaties, outcomes research
Research Summary
Metastatic cancer is associated with a hypercoagulable state; tumor cells can generate thrombin on their surface. We study the biomolecular significance of thrombin receptors on tumor cells. Platelets are required for metastasis in vivo. We showed that treating platelets with thrombin enhanced the adhesion of naive tumor cells to platelets. Active thrombin was necessary on the platelet surface. Thrombin administration with murine tumor cells enhanced pulmonary metastasis via a tail-vein injection in syngeneic mice. The platelet GPIIb-lIla adhesive ligand receptor was important for platelet-tumor cell interaction in vitro and metastasis in vivo.
A unique seven-membrane spanning thrombin receptor was cloned by Vu and colleagues in 1991 which requires proteolysis to produce a tethered ligand capable of activating the thrombin receptor. The thrombin receptor activation peptide (TRAP) from the tethered end recapitulated the thrombin effect on transfected xenopus oocytes and human platelets. We demonstrated the presence of the cloned receptor by RT-PCR in human and murine tumor cells lines and human tumor samples. Thrombin or TRAP treatment of tumor cells supported enhanced adhesion to platelets and increased murine metastasis in syngeneic mice
Currrently were are developing clinical trials to assess the use of antithrombin agents as adjuvants to chemotherapy.
Research Interests Timeline
Clinical Trials and Research Studies
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A Phase I/II Study of M3814 and Avelumab in Combination with Hypofractionated Radiation in Patients with Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
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A Phase 1b Multicenter Study to Determine the Dose Safety Efficacy and Pharmacokinetics of TRK-950 when Used in Combinations with Selected Anti-Cancer Treatment Regimens in Patients with Selected Advanced Solid Tumors
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EMBER-4: A Randomized Open-Label Phase 3 Study of Adjuvant Imlunestrant vs Standard Adjuvant Endocrine Therapy in Patients who have Previously Received 2 to 5 years of Adjuvant Endocrine Therapy for ER+ HER2- Early Breast Cancer with an Increased Risk of Recurrence
Publications
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Shvartsbeyn, Marianna; Meehan, Shane M; Gu, Ping; Nierodzik, Mary Lynn; Perle, Mary Ann
Journal of cutaneous pathology. 2012 Nov ; 39(11):1026-9
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Gany, Francesca; Ramirez, Julia; Nierodzick, Mary Lynn; McNish, Thelma; Lobach, Iryna; Leng, Jennifer
Journal of oncology practice. 2011 Jan ; 7(1):31-8
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Wu, Jennifer; Henderson, Charles; Feun, Lynn; Van Veldhuizen, Peter; Gold, Philip; Zheng, Hui; Ryan, Theresa; Blaszkowsky, Lawrence S; Chen, Haobin; Costa, Max; Rosenzweig, Barry; Nierodzik, MaryLynn; Hochster, Howard; Muggia, Franco; Abbadessa, Giovanni; Lewis, Jonathan; Zhu, Andrew X
Investigational new drugs. 2010 Oct ; 28(5):670-6