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Medication for Takotsubo Syndrome

Treatment for takotsubo syndrome, also known as broken heart syndrome or stress cardiomyopathy, is similar to treatment for a heart attack. Although takotsubo syndrome is commonly thought to be temporary, with reversible damage that improves within days or weeks, it can also lead to other heart problems. This is why it is important to treat the condition proactively, with a care plan that often includes certain medications.

Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE) inhibitors, including drugs such as lisinopril, enalapril, and ramipril, help relax and widen your blood vessels, which makes it easier for your heart to pump blood. They work by blocking the production of a hormone that can constrict blood vessels. Observational research suggests ACE inhibitors may lower cardiovascular risk after takotsubo syndrome.

Angiotensin II Receptor Blockers

Angiotensin II receptor blockers (ARBs), such as losartan, valsartan, and candesartan, have many of the beneficial effects of ACE inhibitors, but they work in a slightly different way. They block the action of a hormone that can constrict blood vessels. Observational research suggests ARBs may lower risk after takotsubo syndrome and are an alternative to ACE inhibitors.


Also known as water pills, diuretics help your body get rid of unneeded water and salt through the urine. This reduces the amount of fluid flowing through your blood vessels, which can decrease pressure on the walls of your arteries. Examples of diuretics include furosemide and spironolactone.

Our Research and Education in Takotsubo Syndrome

Learn more about our research and professional education opportunities.