If you need help accessing our website, call 855-698-9991
Skip to main content

Medication for Failed Back Surgery Syndrome

At NYU Langone, our doctors sometimes prescribe medication to relieve pain and reduce inflammation caused by failed back surgery syndrome. Medication may be used in conjunction with other treatments, such as physical therapy.

Schedule an Appointment

Browse our specialists and get the care you need.

Find a Doctor & Schedule

Nonsteroidal Anti-inflammatory Drugs

Nonsteroidal anti-inflammatory drugs, or NSAIDs, relieve back pain by reducing inflammation in nerve roots and spinal joints. This creates more space in the spinal canal—the opening through which the spinal cord runs—preventing nerve compression. Types of NSAIDs commonly used include ibuprofen, naproxen, and aspirin.

If over-the-counter NSAIDs don’t relieve your pain, your doctor may prescribe a stronger dose for several weeks or until surgery to treat the condition.

Muscle Relaxants

Your doctor may prescribe muscle relaxants to help alleviate pain and reduce muscle spasms, which can occur when muscles are bruised, moved, or cut during back surgery. These medications work by depressing—or lessening the activity of—the central nervous system, relaxing muscles.

Corticosteroid Injections

If NSAIDs don’t relieve back pain, your doctor may recommend an injection of corticosteroids, which reduce inflammation, and a local anesthetic, which reduces pain, into the spinal canal. In some people, the injection can alleviate pain for weeks, months, or even years. However, there is no reliable method for predicting the effectiveness of this treatment.

You can expect to return home immediately after the injection. You may feel slight tenderness at the injection site for a day or two. Doctors typically recommend limiting spinal injections to no more than two or three per year.

Pain Relievers

Rarely, NYU Langone doctors may prescribe opiates, which are derived from poppy plants, or opioids, which are synthetic medications, to treat severe pain in people with failed back surgery syndrome. Because these medications have the potential to become addictive, they are prescribed for short periods of time, typically before or after surgery for failed back surgery syndrome.


Neuroleptic medications stabilize overactive cells in the spinal cord called neurons to relieve back pain associated with nerve compression. Some people who take them daily by mouth report relief from pain.

Your doctor determines how long you take these medications based on the severity of your back pain and how effective they are in relieving your symptoms.

Our Research and Education in Failed Back Surgery Syndrome

Learn more about our research and professional education opportunities.