Welcome to the

High-Risk Cancer Genetics Program

We provide risk assessments and genetic testing for people at increased risk for cancer.

Our High-Risk Cancer Genetics Program at NYU Langone’s Perlmutter Cancer Center provides risk assessments and evaluations to identify and counsel people who may be at increased risk for cancer because of an inherited predisposition. We offer tailored screening to find cancer in its earliest stages, when it is most curable. Some people, including women who test positive for a BRCA gene mutation, may be offered treatment options, such as preventive surgery, to reduce cancer risk.

Not everyone with an inherited gene mutation develops cancer, but it’s important to know your risk to help you make decisions about your health.

If genetic testing results point to an increased risk for cancer, our genetic counselors work closely with hereditary cancer specialists to develop individualized management plans. We also serve as a resource in the medical community, collaborating on cancer genetics research and practices.

Hereditary Cancer Family History Questionnaire

If you have a family history of cancer, our questionnaire can help determine if you would benefit from an evaluation with our genetic counselors to discuss your cancer risk. 

If you do not meet the criteria for an evaluation, you may still consider a genetic counseling appointment to discuss other risk factors and recommendations for managing your risk.

Take the Questionnaire

Make an Appointment

Genetic counseling services are available to all NYU Langone patients with a personal or family history of cancer, as well as those who have a known genetic mutation.

To make an appointment with a genetic counselor in Manhattan, call 646-754-1376.

To make an appointment with a genetic counselor in Brooklyn, call 917-736-9740.

To make an appointment with a genetic counselor in Long Island, call 516-403-1550.

Our Leadership

  • Ophira M. Ginsburg, MD

    Director | Medical Oncology

    Dr. Ginsburg is a medical oncologist and director of the High-Risk Cancer Genetics Program. She and her team of genetic counselors help families understand their risks for developing cancer, and provide risk-reduction strategies for those at high risk. Her research examines the causes of cancer and cancer disparities in low- and middle-income countries with the goal of improving outcomes. She has co-authored numerous peer-reviewed articles, books, and book chapters about cancer.

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  • John G. Pappas, MD

    Clinical Genetics

    Dr. Pappas is a clinical geneticist and associate professor of pediatrics at NYU Langone. He directs clinical genetics services for NYU Langone’s Department of Pediatrics. He studies the characteristics and genetics of hereditary syndromes and provides evaluations for genetic diagnosis and treatments for children and adults, believing that detailed phenotyping and genotyping can improve our understanding of genetic factors in disease and lead to the development of new treatments.

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  • Julia A. Smith, MD, PhD

    Medical Oncology

    Dr. Smith is a medical oncologist and clinical assistant professor of medicine at NYU Langone. She sees people who are at high risk for developing cancer.

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