If you need help accessing our website, call 855-698-9991
Skip to main content
NYU Langone Provider

Matthias C. Kugler, MD

NYU Langone Provider
  • Specialties: Pulmonary Medicine, Critical Care
  • Treats: Adults
  • Languages: English, German
  • Phone: 212-598-6321
View Scheduling Options

Education and Training
  • Fellowship, NYU School of Medicine, Pulmonary and Critical Care Medicine, 2012
  • Residency, NYU School of Medicine, 2009
  • MD from Technical University of Munich, 2003

Is this your profile?

Edit profile

This provider accepts the following insurance plans.

  • Aetna
     
    • Aetna HMO
    • Aetna Indemnity
    • Aetna International
    • Aetna Medicare Advantage
    • Aetna Open Access EPO
    • Aetna Open Access HMO
    • Aetna POS
    • Aetna POS (American Express Employer)
    • Aetna PPO
    • Aetna Signature Administrators PPO
    • Aetna Student Plan
    • Allied
    • Chesterfield Resources Inc
    • Christian Brothers Services
    • CoreSource
    • Nippon Life of America-Aetna
    • Nippon Life-Aetna
    • Starmark
    • WellNet
  • Anthem BCBS Health Plus
     
    • BCBS Healthplus Essential Plan 1
    • BCBS Healthplus Essential Plan 2
    • BCBS Healthplus Essential Plan 3
    • BCBS Healthplus Essential Plan 4
    • BCBS Healthplus Gatekeeper exchange
    • BCBS Healthplus Mediblue Advantage
    • BCBS Healthplus NY Child Health Plus NY
    • BCBS Healthplus NY Medicaid Managed Care NY
    • BCBS Healthplus Special Needs
    • Empire Mediblue Healthplus Dual
  • Anthem Blue Cross Blue Shield
     
    • Anthem BCBS CT PPO
    • Anthem BCBS CT Pathway PPO
    • BCBS Blue Access EPO Large Group
    • BCBS Blue Access EPO Small Group
    • BCBS Blue Access GEPO Small Group
    • BCBS Blue Access PPO Large Group
    • BCBS EPO
    • BCBS EPO (BlackRock Employees)
    • BCBS EPO (LICH Employees)
    • BCBS EPO - Empire EPO (NYU Langone Employees)
    • BCBS EPO - Empire EPO (Sunset Park/Family Health Center Employees)
    • BCBS EPO - Empire NYU Care (NYU Langone Employees)
    • BCBS EPO - Empire NYU Care (Sunset Park/Family Health Center Employees)
    • BCBS Federal Program
    • BCBS Florida Blue Care HMO
    • BCBS Florida Blue Medicare PPO
    • BCBS Florida Blue Options PPO
    • BCBS Florida Blue Select
    • BCBS Florida MyBlue HMO
    • BCBS Florida Simply Blue
    • BCBS Florida Traditional PPC
    • BCBS HMO
    • BCBS Indemnity
    • BCBS Local 32BJ Employees
    • BCBS Mediblue Medicare HMO
    • BCBS Mediblue Medicare PPO
    • BCBS Mediblue Select HMO/Extra HMO
    • BCBS POS
    • BCBS PPO
    • BCBS PPO (BlackRock Employees)
    • BCBS PPO (LICH Employees)
    • BCBS PPO - Empire PPO (Sunset Park/Family Health Center Employees)
    • BCBS PPO/EPO Small Group
    • New York Hotel Trades
  • Cigna
     
    • Apwu Health Plan
    • Cigna - Humana
    • Cigna Great West PPO
    • Cigna HMO
    • Cigna Indemnity
    • Cigna Managed Care/POS
    • Cigna Medicare Advantage
    • Cigna NALC
    • Cigna Open Access
    • Cigna Open Access PPO
    • Cigna Oscar
    • Cigna PPO
    • Cigna Premier Plus
    • Great West HMO
    • Kaiser Permanente
    • MVP-Cigna Network
    • Wellfleet-NYU Student
  • Connecticare
     
    • Connecticare Bridge
    • Connecticare Commercial
  • Elderplan
     
    • Elderplan
    • Elderplan FIDA
    • Elderplan Medicare Advantage Plan
  • Emblem
     
    • Emblem Select Care Bronze Small Group
    • Emblem Select Care EPO
    • Emblem Select Care Gold Small Group
    • Emblem Select Care HMO
    • Emblem Select Care PPO
    • Emblem Select Care Platinum Small Group
    • Emblem Select Care Silver Small Group
  • GHI
     
    • American Plan Administrators
    • GHI CBP (City of New York Employees)
    • GHI Emblem Health EPO
    • GHI Emblem Health PPO
    • GHI HMO
    • GHI HMO Medicare
    • GHI Medicare PPO
    • GHI Medicare Supplement
    • GHI Network Access - Benefit Services of PA
    • GHI Network Access - Humana
    • GHI Network Access - Total Plan Concepts
    • IUOE Local 14-14B
    • Wlny-TV Inc.
  • HIP
     
    • Emblem Essential Plan 1
    • Emblem Essential Plan 2
    • Emblem Essential Plan 3
    • Emblem Essential Plan 4
    • HIP Access I
    • HIP Access II
    • HIP Bridge
    • HIP Child Health Plus
    • HIP EPO
    • HIP HMO
    • HIP Medicaid Enhanced Care
    • HIP Medicare Supplement
    • HIP POS
    • HIP PPO
    • HIP Prime Basic Exchange
    • HIP Prime Bronze
    • HIP Prime Bronze Exchange
    • HIP Prime Catastrophic Exchange
    • HIP Prime Gold
    • HIP Prime Gold Exchange
    • HIP Prime Platinum
    • HIP Prime Platinum Exchange
    • HIP Prime Silver
    • HIP Prime Silver Exchange
    • HIP VIP Medicare Bold
    • HIP VIP Medicare Prime
    • Vytra HMO
  • Hamaspik Choice
     
    • Hamaspik Choice Medicare DSNP
  • Healthfirst
     
    • Health And Recovery Plan (Harp)
    • Healthfirst Bronze Leaf Exchange
    • Healthfirst Bronze Total, Pro, Plus EPO
    • Healthfirst Child Health Plus
    • Healthfirst Essential Plan 1 & 2
    • Healthfirst Essential Plan 3 & 4
    • Healthfirst Gold Leaf Exchange
    • Healthfirst Gold Total, Pro, Plus EPO
    • Healthfirst Green Leaf Exchange
    • Healthfirst Medicaid
    • Healthfirst Medicare
    • Healthfirst Medicare/NYU Risk
    • Healthfirst Personal Wellness Plan
    • Healthfirst Platinum Leaf Exchange
    • Healthfirst Platinum Total, Pro, Plus EPO
    • Healthfirst Senior Health Partners
    • Healthfirst Silver Leaf Exchange
    • Healthfirst Silver Total, Pro, Plus EPO
  • Hotel Trades Council
     
    • Hotel Trades Council
  • Humana
     
    • Humana Medicare Advantage
  • Local 1199
     
    • Local 1199 - NYU Hospital Member Choice
    • Local 1199 PPO
  • Longevity Health Plan
     
    • Longevity Health Plan Medicare
  • Magnacare
     
    • Magnacare PPO
  • Medicaid of New York
     
    • NYS Medicaid
  • Medicare
     
    • Medicare Part A and B
    • Medicare Part B
  • Metroplus
     
    • Metroplus Bronze Plus Plan Exchange
    • Metroplus Child Health Plus
    • Metroplus Essential Plan 1 and 2
    • Metroplus Essential Plan 3 and 4
    • Metroplus Gold
    • Metroplus Gold Plus Plan Exchange
    • Metroplus Goldcare
    • Metroplus Medicaid Managed Care
    • Metroplus Medicare
    • Metroplus Medplus Plan Exchange
    • Metroplus Platinum Plus Plan Exchange
    • Metroplus Silver Plus Plan Exchange
  • Multiplan
     
    • AXA Assistance USA
    • Administrative Concepts
    • Beech Street PPO
    • Diversified Administration Corporation
    • Fiserv Health
    • GEHA
    • Global Excel
    • Global Health
    • Guardian Life Insurance Co Of America
    • Health Net Of California
    • Health Republic Of NJ
    • Humana Health Plan
    • Insurance Design Administrators
    • Kaiser Foundation
    • Kaiser Permanente
    • Meritain Health
    • Multiplan PPO
    • Multiplan-Capital Dist Phys Health
    • Mutual Of Omaha
    • Nippon Life Ins Co
    • PHCS
    • Professional Benefit Admin
    • Qualcare Inc
    • Screen Actors Guild
    • Teamsters Allied Benefits
    • US Life Insurance Company
  • NYSHIP - The Empire Plan
     
    • NYS Health Insurance Plan - The Empire Plan, Excelsior Plan, NY Student Employee Health Plan
  • Oxford
     
    • Oxford Health Plans Freedom
    • Oxford Health Plans Liberty
  • POMCO Insurance Company
     
    • POMCO Insurance Company
  • Partners Health Plan Inc
     
    • Partners Health Plan FIDA
    • Partners Health Plan Medicaid
    • Partners Health Plan Medicare
  • Qualcare Inc.
     
    • Qualcare Direct
  • Railroad Medicare
     
    • Palmetto GBA Railroad Medicare
  • Sedgwick WTC
     
    • World Trade Center - Sedgwick
  • Tricare
     
    • TriWest
    • Tricare
    • US Family Health Plan
  • United Healthcare
     
    • AARP Medicare Complete
    • Bind Benefits inc
    • Oxford Health Plans Medicare Advantage
    • UMR
    • Unite Healthcare (NY University Care Plan)
    • United Healthcare AARP
    • United Healthcare All Savers
    • United Healthcare Choice
    • United Healthcare Choice (AMEX employees)
    • United Healthcare Choice (Blackrock employees)
    • United Healthcare Choice (CBS employees)
    • United Healthcare Choice (Simon
    • United Healthcare EPO
    • United Healthcare EPO (NYU Langone Health Employees)
    • United Healthcare Golden Rule Insurance
    • United Healthcare HMO
    • United Healthcare Indemnity
    • United Healthcare Indemnity (NYU Langone Health Employees)
    • United Healthcare Medicare
    • United Healthcare Navigate
    • United Healthcare Nexus
    • United Healthcare Nexus (Amex Employees)
    • United Healthcare POS
    • United Healthcare PPO
    • United Healthcare Plus (NYU Langone Health Employees)
    • United Healthcare Student Resources
    • United Healthcare Student Resources (NYU)
    • United Healthcare Value, Advantage and HDHP (New York University employees)
    • UnitedHealthcare Choice (NY Power Authority Employees)
  • VA Community Care Network
     
    • VA CCN Optum
  • VNS Choice Advantage
     
    • VNS Medicare Advantage
    • VNS NY Choice Select Health
  • Village Care
     
    • VillageCare
  • WTC Health Program
     
    • NY Fire Department - WTC
    • WTC Health Program
View All Accepted Plans This list of insurances changes regularly, and insurance plans listed may not be accepted at all office locations for this provider. Before your appointment, please confirm with your insurance company that this provider accepts your insurance.

Matthias C. Kugler, MD does not accept insurance.

Locations and Appointments

NYU Langone Ambulatory Care - 23rd Street

324 East 23rd Street, New York, NY 10010

Interests

adult fibrosing lung diseases, idiopathic pulmonary fibrosis, IPF, CPFE

Research Summary

Two areas of interest evolved from my research and clinical activities. On the cell biology level, I am interested in how cell surface receptors communicate with their environment in physiologic and pathophysiologic states. The functional consequences of altered signaling are of particular interest for me as a physician since they give me further insight into disease mechanisms, such as aberrant integrin or growth factor receptor signaling in pulmonary fibrosis. On the clinical level, I have become particularly interested in IPF (idiopathic pulmonary fibrosis), a fatal, progressive lung disease with unpredictable clinical course, a median survival of <4 years and no effective treatment. Despite extensive research its underlying mechanisms remain unclear. One potential way I have studied involves EMT. In EMT, epithelial cell injury induces phenotype change to a mesenchymal type, resulting in interstitial matrix accumulation in alveolar walls and progressive pulmonary fibrosis with loss of function. Another potential mechanism I am currently studying involves embryonic signaling pathways, such as Hedgehog (HH) signaling, which are usually suppressed in adult uninjured lung, but might become reactivated as pathogenic mechanism in IPF.

In our lab we have shown HH pathway reactivation in lung fibroblasts in two important settings: (1) during alveolar septum formation in the postnatal lung and (2) in bleomycin-injured fibrotic lung. In the early postnatal developmental setting, inhibition of HH signaling produced alveolar airspace enlargement and septum wall thinning without affecting septum formation. This indicates the importance of precise temporal decrease in mesenchyme for normal lung structure. In the pathophysiological setting, the exacerbation of bleomycin-induced fibrosis by SHH over-expression implies that aberrant pathway activity prevents the demise of lung fibroblasts during fibrosis resolution.

The long-term goals of my work are to better understand the molecular signatures of pulmonary fibrosis by studying their characteristics in pathophysiologically relevant mouse models to elucidate novel mechanisms and improve treatment options.

These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
Loading...
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

  • Microbial and human biomarkers of thoracic disease after lung transplantation

    Learn More
View All Research Studies (1)

  • Natalini, Jake G; Wong, Kendrew K; Nelson, Nathaniel C; Wu, Benjamin G; Rudym, Darya; Lesko, Melissa B; Qayum, Seema; Lewis, Tyler C; Wong, Adrian; Chang, Stephanie H; Chan, Justin C Y; Geraci, Travis C; Li, Yonghua; Wang, Chan; Li, Huilin; Pamar, Prerna; Schnier, Joseph; Mahoney, Ian J; Malik, Tahir; Darawshy, Fares; Sulaiman, Imran; Kugler, Matthias C; Singh, Rajbir; Collazo, Destiny E; Chang, Miao; Patel, Shrey; Kyeremateng, Yaa; McCormick, Colin; Barnett, Clea R; Tsay, Jun-Chieh J; Brosnahan, Shari B; Singh, Shivani; Pass, Harvey I; Angel, Luis F; Segal, Leopoldo N

    American journal of respiratory & critical care medicine. 2024 Feb 15;

  • Sulaiman, Imran; Wu, Benjamin G; Chung, Matthew; Isaacs, Bradley; Tsay, Jun-Chieh J; Holub, Meredith; Barnett, Clea R; Kwok, Benjamin; Kugler, Matthias C; Natalini, Jake G; Singh, Shivani; Li, Yonghua; Schluger, Rosemary; Carpenito, Joseph; Collazo, Destiny; Perez, Luisanny; Kyeremateng, Yaa; Chang, Miao; Campbell, Christina D; Hansbro, Philip M; Oppenheimer, Beno W; Berger, Kenneth I; Goldring, Roberta M; Koralov, Sergei B; Weiden, Michael D; Xiao, Rui; D'Armiento, Jeanine; Clemente, Jose C; Ghedin, Elodie; Segal, Leopoldo N

    American journal of respiratory & critical care medicine. 2023 Nov 15; 208(10):1101-1114

  • Sachan, Nalani; Phoon, Colin K L; Zilberberg, Lior; Kugler, Matthias C; Ene, Taylor; Mintz, Shana B; Murtada, Sae-Il; Weiss, Dar; Fishman, Glenn I; Humphrey, Jay D; Rifkin, Daniel B

    Matrix biology. 2023 Aug ; 121:41-55

Read All Publications (24)