Douglas S. Holmes, MD

  • Specialties: Electrophysiology, Cardiology
  • Language: English
  • Phone: 212-263-7149
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About Me

Conditions and Treatments

dilated cardiomyopathy, ventricular tachycardia (VT), congenital heart defect, cardiac lead extraction, Brugada syndrome, heart throbbing, rapid heartbeat, abnormal heart rhythms, slow heartbeat, pacemaker placement, cardiac device implant, congenital heart disease, sarcoidosis, ventricular fibrillation, fainting, atrial flutter, ventricular arrhythmia, long QT syndrome, complication associated with cardiac implant, electrophysiology, atrial fibrillation, automatic implantable cardioverter-defibrillators
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Credentials

Positions
  • Assistant Professor, Department of Medicine
  • Assistant Professor, Department of Pediatrics
Board Certifications
  • American Board of Internal Medicine (Clinical Cardiac Electrophysiology), 1999
  • American Board of Internal Medicine (Cardiovascular Disease), 1998
Education and Training
  • Fellowship, NYU Medical Center, Cardiac Electrophysiology, 1999
  • Fellowship, NYU Medical Center, Cardiology, 1998
  • Residency, NYU Medical Center, 1995
Departments

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Locations and Appointments

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  • Aetna
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NYU Langone Heart Rhythm Center

403 East 34th Street, 4th Floor
New York, NY 10016

NYU Langone Medical Associates - Chelsea

275 7th Avenue, Third Floor
New York, NY 10001

NYU Electrophysiology

560 1st Avenue, 5th Floor
New York, NY 10016

Research My Research

Interests

cellular mechanisms, cardiac arrhythmias , sudden death, atrial fibrillation

Research Summary

Atrial fibrillation (AF) is the most common clinical arrhythmia seen and results in significant morbidity and mortality. As a result, there is tremendous interest in understanding the mechanisms leading to and supporting AF. Clinically, AF starts with ectopic atrial activity originating from the pulmonary veins or the body of the left atrium. Should these atrial beats coincide with a vulnerable atrial substrate able to support multiple wavelet reentry, AF results. While there are currently no good animal models to study ectopic atrial activity, an atrial tachy-paced model is used to study the atrial changes resulting from high frequency electrical activity. While this model recapitulates many of the features of clinical AF, it also has numerous shortcomings. More recently, it has been observed that following congestive heart failure, atrial structures dilate and are thus susceptible to AF initiation. This model is more closely related to human pathophysiology. We are using a rabbit model of myocardial infarction to study the cellular changes induced by pressure overload atrial dilation.

At the cellular level, we are investigating the electrophysiologic alterations underlying abnormal automaticity and triggered activity. Failing cardiac tissues undergo remodeling of their ion handling proteins characterized by up or down regulation of protein expression. In general, these changes tend to amplify subthreshold electrical events into triggered activity. While the mechanisms behind ventricular ectopy have become well characterized, those of the atrium are less well understood. Among the differences between atrial and ventricular cells is the presence of IP3 receptors in atrial tissue. These calcium-releasing receptors are up regulated in failing atrium and may play a role in both triggered activity within the atrial free wall and abnormal automaticity from spontaneously firing cells within the pulmonary veins. Using confocal microscopy and patch clamp techniques, in a collaboration with the laboratory of Dr. William Coetzee and Michael Artman, we simultaneously measure subcellular calcium transients and sarcolemmal membrane currents. Interactions between excitation-contraction mechanisms and IP3 calcium release could form the basis of new atrial specific therapeutic targeting.

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • Barbhaiya, Chirag R; Aizer, Anthony; Knotts, Robert; Bernstein, Scott; Park, David; Holmes, Douglas; Chinitz, Larry A

    Journal of interventional cardiac electrophysiology. 2018 Sep 27;

  • Two procedure outcomes for non-paroxysmal atrial fibrillation using a contact-force sensing radiofrequency ablation catheter: Left atrial posterior wall isolation versus stepwise linear ablation [Meeting Abstract]

    Knotts, R; Barbhaiya, C R; Soria, C; Bernstein, S A; Park, D S; Fowler, S J; Holmes, D; Aizer, A; Chinitz, L A

    Heart rhythm. 2018 May; Conference:(39th):S535

  • Healthcare utilization impact and procedural outcomes of urgent catheter ablation for treatment-resistant symptomatic atrial fibrillation [Meeting Abstract]

    Barbhaiya, C R; Mathews, T; Warrier, N P; Beccarino, N; Holmes, D; Aizer, A; Jones, S; Chinitz, L A

    Heart rhythm. 2018 May; Conference:(39th):S313

Read All Publications (47)