- Professor, Department of Psychiatry at NYU Grossman School of Medicine
- Professor, Department of Pathology at NYU Grossman School of Medicine
- Fellowship Program Director, Geriatric Psychiatry
- American Board of Psychiatry & Neurology - Psychiatry, 1982
Education and Training
- Fellowship, Wayne State University Medical Center, Geriatric Psychiatry, 1982
- Residency, Metropolitan Hospital, 1980
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Insurance Plans Accepted
Nunzio Pomara, MD does not accept insurance.
Research My Research
pharmacogenetics, Alzheimer's disease, drug-induced cognitive toxicity, late-life depression
A major focus of Dr. Pomara’s research has been to elucidate pharmacokinetic and pharmacodynamic factors that may contribute to individual vulnerability to drug induced cognitive and psychomotor toxicity in the elderly. He has shown that certain variants of the APOE and TOMM40 genes increase risk for drug-induced adverse events unrelated to pharmacokinetic factors and likely reflecting pharmacodynamic mechanisms.
Other important contributions include his early reports of increased activity in the HPA axis associated with both aging and Alzheimer’s disease (AD), as determined by studies of baseline cortisol and dexamethasone response. These results led to the first pilot clinical trial that examined the cognitive effects of the glucocorticoid receptor antagonist, RU486, in AD. Dr. Pomara also provided early evidence of a decreased cortisol response to naltrexone and an elevation in CSF-glutamate in Alzheimer’s patients.
Dr. Pomara additionally presented the first evidence that late life depression, a condition associated with increased risk for AD or prodromal phase, may be accompanied by state-dependent disturbances in central and peripheral metabolism of amyloid-beta, a peptide implicated in AD.
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Research Interests Timeline
Clinical Trials and Research Studies
Clinical neuropsychiatry: journal of treatment evaluation. 2022 Dec 01; 19(6):370-378
Translational psychiatry. 2022 Jul 28; 12(1):301
Neuropsychology. 2022 Jan 01; ?-?