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Affiliated Provider
Affiliated providers provide medical care at an NYU Langone location or a private practice, and are not employed by NYU Langone Health.

Nunzio Pomara, MD

Affiliated Provider
Affiliated providers provide medical care at an NYU Langone location or a private practice, and are not employed by NYU Langone Health.
  • Specialty: Adult Psychiatry
  • Treats: Adults
  • Language: English

Positions
Board Certifications
  • American Board of Psychiatry & Neurology - Psychiatry, 1982
Education and Training
  • Fellowship, Wayne State University Medical Center, Geriatric Psychiatry, 1982
  • Residency, Metropolitan Hospital, 1980

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Interests

pharmacogenetics, Alzheimer's disease, drug-induced cognitive toxicity, late-life depression

Research Summary

A major focus of Dr. Pomara’s research has been to elucidate pharmacokinetic and pharmacodynamic factors that may contribute to individual vulnerability to drug induced cognitive and psychomotor toxicity in the elderly. He has shown that certain variants of the APOE and TOMM40 genes increase risk for drug-induced adverse events unrelated to pharmacokinetic factors and likely reflecting pharmacodynamic mechanisms.

Other important contributions include his early reports of increased activity in the HPA axis associated with both aging and AD, as determined by studies of baseline cortisol and dexamethasone response. These results led to the first pilot clinical trial that examined the cognitive effects of the glucocorticoid receptor antagonist, RU486, in AD. Dr. Pomara also provided the first report on an absence of a cortisol response to naltrexone and an elevation in CSF-glutamate in Alzheimer’s patients.

Dr. Pomara additionally presented the first evidence that late life depression, a condition associated with increased risk for Alzheimer’s disease (AD) or prodromal phase, may be accompanied by disturbances in central and peripheral metabolism of amyloid-beta, a peptide implicated in AD. More recently, he has been collaborating with the NYU Cohen Veterans Center to identify biomarkers for PTSD/TBI.

Academic Contact

Academic office

One Park Avenue

Eighth Floor

New York, NY 10016

Phone

646-754-4848

These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

  • Depression treatment and A dynamics: A study of Alzheimer s disease risk

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  • Transcranial Photobiomodulation for Alzheimer's Disease (TRAP-AD)

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View All Research Studies (2)

Read All Publications (198)