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Michael B. Whitlow, MD

  • Specialty: Dermatology
  • Language: English
  • Phone: 212-753-5382
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About Me

Conditions and Treatments

eczema, psoriasis, acne, pemphigus

Credentials

Positions
  • Clinical Associate Professor, Ronald O. Perelman Department of Dermatology
Board Certifications
  • American Board of Dermatology (Clinical & Lab Dermatological Immu), 1989
  • American Board of Dermatology - Dermatology, 1988
Education and Training
  • Residency, NYU Medical Center, 1988
  • MD from Johns Hopkins University, 1984

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Locations and Appointments

View Insurance Plans Accepted
  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna International
    • Aetna Medicare Managed Care
    • Aetna Meritain Health
    • Aetna Open Access Elect Choice (EPO)
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    • Aetna POS (American Express Employer)
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    • Chesterfield Resources Inc
    • Christian Brothers Services
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    • Healthscope
    • Nippon Life of America—Aetna
    • Nippon Life—Aetna
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  • Cigna
    • Apwu Health Plan
    • Cigna Great West PPO
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    • Consolidated Health Plans-NYU Student
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  • MVP Select Care Inc
    • MVP Preferred EPO
    • MVP Select Care Inc.
  • NYSHIP - The Empire Plan
    • NYS Health Insurance Plan - The Empire Plan
  • United Healthcare
    • United Healthcare Choice (AMEX employees)
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    • UMR WTC Health Program
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    • United Healthcare EPO (NYU Langone Health Employees)
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    • United Healthcare Plus (NYU Langone Health Employees)
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Michael Whitlow, M.D.

635 Madison Avenue
New York, NY 10022

Research My Research

Interests

terminal complement proteins

Research Summary

Our goal is to better understand how the terminal complement proteins damage cell membranes and how cells protect themselves from such complement damage. Complement-induced membrane damage is mediated by the terminal complement proteins C5- C9. When activated, these terminal complement proteins form transmembrane channels in the membrane of nearby cells. We found that complement channels are not formed randomly but within membrane domains. If complement preferentially localizes to membrane domains, a receptor must be within the domains for one or more of the terminal complement proteins. Aterminal complement proteinss the initial interaction between the terminal complement proteins and the membrane occurs with C5b6, this complex is the most likely ligand of such a receptor.

We identified these molecules on the erythrocyte surface that the terminal complement proteins bind to: anionic phospholipids, gangliosides, and sialic acid present on glycophorin. We have also shown that the stage of complement channel formation at which this interaction occurs is at the stage of C5b6 binding to the membrane. The focus of our research now is to understand how C5b6 interacts with these anionic molecules and to use this information to develop soluble inhibitors of the terminal complement proteins. This work is clinically important because the terminal complement proteins are a primary focus in the destruction of xenogeneic grafts, i.e., grafts between species. Inhibitors such as the ones we are developing may increase the ability of these xenografts to be used in transplantation.

 

 

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • Tran, Kathleen; Boyd, Kevin P; Robinson, Maria R; Whitlow, Michael

    Dermatology online journal. 2013 Dec 16; 19(12):20718-20718

  • Anolik, Robert; Firoz, Bahar; Walters, Ruth F; Meehan, Shane A; Tsou, Hui C; Whitlow, Michael; Wainwright, Brent

    Dermatology online journal. 2008 Oct 15; 14(10):25-25

  • Aquatic dermatology

    Whitlow M

    Current dermatologic diagnosis & treatment. Philadelphia : Lippincott Williams & Wilkins, 2001. p.16-17. (3678)

Read All Publications (32)

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