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Affiliated Provider
Affiliated providers provide medical care at an NYU Langone location or a private practice, and are not employed by NYU Langone Health.

Ramin Herati, MD

Affiliated Provider
Affiliated providers provide medical care at an NYU Langone location or a private practice, and are not employed by NYU Langone Health.
  • Specialty: Infectious Diseases
  • Language: English

Board Certifications
  • American Board of Internal Medicine (Infectious Disease), 2013
  • American Board of Internal Medicine - Internal Medicine, 2011
Education and Training
  • Fellowship, University of Pennsylvania School of Medicine, Infectious Diseases, 2013
  • Residency, John Hopkins Bayview Med, Internal Medicine, 2011
  • MD from Washington University, 2008

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Germinal centers, Vaccine responses, T follicular helper CD4 cells, Rational vaccines, Aging

Research Summary

Antibody responses are at the core of nearly every vaccine in clinical use today, yet our ability to rationally direct the antibody response remains limited. No strategies currently exist to selectively manipulate the antibody response. During an antibody response, T follicular helper CD4 cells (Tfh) provide critical help and direction to B cells. Over the past several years, we have developed approaches to look at Tfh in circulation and in tissue after vaccination. From these studies, we learned that circulating Tfh are a long-lived memory T cell population and can provide a "window" into the environment of the lymph node. We are interested in how Tfh repertoire is maintained, how the overall inflammatory environment shapes the T-B cell interaction, and how immunomodulatory therapeutics can be used to directly manipulate Tfh activity in research subjects. Understanding the T cells at the heart of a vaccine response will be crucial to designing personalized, rational vaccine strategies as well as myriad other scenarios where antibody responses are key. 

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These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

  • Serologic Testing and Genomic Analysis of Autoimmune ImmuneMediated and Rheumatic Patients with COVID-19 (SAGA)

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  • A Phase III Randomized Double-blind Placebo-controlled Multicenter Study in Adults to Determine the Safety Efficacy and Immunogenicity of AZD1222 a Non-replicating ChAdOx1 Vector Vaccine for the Prevention of COVID-19

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  • A Phase 1/2 Placebo-Controlled Randomized Observer-Blind Dose-Finding Study to Describe the Safety Tolerability Immunogenicity and Potential Efficacy of SARS CoV 2 RNA Vaccine Candidates Against COVID 19 in Healthy Adults

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View All Research Studies (5)

Read All Publications (24)