Credentials
Positions
- Assistant Professor, Department of Medicine at NYU Grossman School of Medicine
- Assistant Professor, Department of Microbiology at NYU Grossman School of Medicine
Board Certifications
- American Board of Internal Medicine (Infectious Disease), 2013
- American Board of Internal Medicine - Internal Medicine, 2011
Education and Training
- Fellowship, University of Pennsylvania School of Medicine, Infectious Diseases, 2013
- Residency, John Hopkins Bayview Medical Center, Internal Medicine, 2011
- MD from Washington University-St Louis, 2008
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Ramin Herati, MD does not accept insurance.
Research My Research
Interests
Germinal centers, Vaccine responses, T follicular helper CD4 cells, Rational vaccines, Aging
Research Summary
Antibody responses are at the core of nearly every vaccine in clinical use today, yet our ability to rationally direct the antibody response remains limited. No strategies currently exist to selectively manipulate the antibody response. During an antibody response, T follicular helper CD4 cells (Tfh) provide critical help and direction to B cells. Over the past several years, we have developed approaches to look at Tfh in circulation and in tissue after vaccination. From these studies, we learned that circulating Tfh are a long-lived memory T cell population and can provide a "window" into the environment of the lymph node. We are interested in how Tfh repertoire is maintained, how the overall inflammatory environment shapes the T-B cell interaction, and how immunomodulatory therapeutics can be used to directly manipulate Tfh activity in research subjects. Understanding the T cells at the heart of a vaccine response will be crucial to designing personalized, rational vaccine strategies as well as myriad other scenarios where antibody responses are key.
Academic Contact
Academic office
430 E 29th St, Alexandria Building - West
3rd Floor, Room 314
New York City, NY 10016
Phone
Lab Website
Research Interests Timeline
Clinical Trials and Research Studies
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Predicting poor vaccine responders to Hepatitis B vaccination
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Serologic Testing and Genomic Analysis of Autoimmune ImmuneMediated and Rheumatic Patients with COVID-19 (SAGA)
Publications
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Samanovic, Marie I; Cornelius, Amber R; Gray-Gaillard, Sophie L; Allen, Joseph Richard; Karmacharya, Trishala; Wilson, Jimmy P; Wesley Hyman, Sara; Tuen, Michael; Koralov, Sergei B; Mulligan, Mark J; Sedaghat Herati, Ramin
Science translational medicine. 2021 Dec 07; eabi8961
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Herati, Ramin Sedaghat; Knorr, David A; Vella, Laura A; Silva, Luisa Victoria; Chilukuri, Lakshmi; Apostolidis, Sokratis A; Huang, Alexander C; Muselman, Alexander; Manne, Sasikanth; Kuthuru, Oliva; Staupe, Ryan P; Adamski, Sharon A; Kannan, Senthil; Kurupati, Raj K; Ertl, Hildegund C J; Wong, Jeffrey L; Bournazos, Stylianos; McGettigan, Suzanne; Schuchter, Lynn M; Kotecha, Ritesh R; Funt, Samuel A; Voss, Martin H; Motzer, Robert J; Lee, Chung-Han; Bajorin, Dean F; Mitchell, Tara C; Ravetch, Jeffrey V; Wherry, E John
Nature immunology. 2022 Aug ; 23(8):1183-1192
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Herati, Ramin Sedaghat; Muselman, Alexander; Vella, Laura; Bengsch, Bertram; Parkhouse, Kaela; Del Alcazar, Daniel; Kotzin, Jonathan; Doyle, Susan A; Tebas, Pablo; Hensley, Scott E; Su, Laura F; Schmader, Kenneth E; Wherry, E John
Science immunology. 2017 Feb ; 2(8):