About Me
My curiosity about science was heightened by a high school biology class, during which I wondered at the complex phenomena such simple elements—carbon, hydrogen, oxygen, and nitrogen—can create. Then the genetic code was discovered, and it seemed we suddenly had so many answers at our fingertips.
When I studied genetics in closer detail, however, I found more questions than answers. My interest in incurable diseases, especially those brought about by genes associated with unfavorable traits, grew during the years I studied in my home country, Greece, at the University of Athens. There, I discovered my passion: medical genetics. There was no specific program in Greece where I could further my training, so I moved to the United States and pursued pediatrics and genetics.
Helping families struggling with genetic conditions has become my priority. In my practice, I evaluate children with possible genetic disorders. I’m specifically interested in genomic microdeletions and microduplications—small mutations that are associated with different conditions, such as autism—and I hope to study these mutations in future research projects.
Patients and parents of patients often don’t realize that nature changes and distributes genes randomly. I try to eliminate the guilt that can accompany a genetic disease diagnosis by explaining that new mutations occur naturally, and that nobody has a choice in deciding which part of their DNA is transmitted to their kids.
It is fulfilling to be able to direct families, parents, and children with genetic conditions to the appropriate specialties. I love doing what I can to make their lives easier. I can empower families with the explanation that a DNA mutation is totally natural, untouchable by humans. Most of all, being a part of family discussions and decisions during personal, and sometimes very painful, times is a privilege and responsibility that extends beyond professional duties.
In addition to educating patients, I have a responsibility to educate students. I am actively involved in teaching first- and third-year medical students, as well as residents and fellows, about the main features of genetic syndromes, prompt communication of a diagnosis, and familiarity with advances in the field of medical genetics.
Conditions and Treatments
Conditions
- achondroplasia
- arthrogryposis
- asperger syndrome
- autism
- birthmark
- cerebral palsy
- charcot marie tooth disease
- cleft palate
- coarctation
- congenital hydrocephalus
- congenital scoliosis
- connective tissue disease
- cystic fibrosis
- ear malformation
- epilepsy & seizure disorders
- genetic skin disease
- growth disorder
- hand deformity
- intellectual disability
- kabuki syndrome
- kidney malformation
- klinefelter syndrome
- learning disorder
- legg-calvé-perthes disease
- limb abnormality
- lysosomal storage disease
- marfan syndrome
- movement disorders
- multiple pterygium syndrome
- muscular dystrophy
- neurofibromatosis
- normal pressure hydrocephalus
- pervasive developmental disorder
- pseudoachondroplasia
- short stature
- skeletal dysplasia
- spina bifida
- vascular malformations in the torso & limbs
Treatments
- craniosynostosis
Learn more about conditions we treat at NYU Langone:
Achondroplasia in Children , Arthrogryposis in Children , Autism Spectrum Disorder in Children , Birthmarks in Children , Cerebral Palsy in Children , Congenital Heart Defects in Children , Hydrocephalus in Children , Scoliosis in Children , Lupus in Children , Cystic Fibrosis in Children , Congenital Hand Deformities , Congenital Kidney & Urinary Tract Problems , Learning Disorders in Children , Legg-Calvé-Perthes Disease in Children , Clubfoot in Children , Osteogenesis Imperfecta in Children , Muscular Dystrophy , Neurofibromatosis , Spina Bifida in ChildrenCredentials
Positions
- Professor, Department of Pediatrics at NYU Grossman School of Medicine
- Division Director, Peditatric Clinical Genetics
Board Certifications
- American Board of Medical Genetics-Clinical Genetics & Genomics, 2020
- American Board of Pediatrics - Pediatrics, 1992
Education and Training
- Fellowship, Beth Israel Medical Center, Clinical Genetics, 1995
- Residency, Beth Israel Medical Center, Pediatrics, 1991
- MD from University of Athens, 1985
Is this your profile?
Edit profileInsurance Plans Accepted
This provider accepts the following insurance plans.
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Aetna
- Aetna HMO
- Aetna Indemnity
- Aetna International
- Aetna Medicare Advantage
- Aetna Open Access EPO
- Aetna Open Access HMO
- Aetna POS
- Aetna POS (American Express Employer)
- Aetna PPO
- Aetna Signature Administrators PPO
- Aetna Student Plan
- Allied
- Chesterfield Resources Inc
- Christian Brothers Services
- CoreSource
- Nippon Life of America-Aetna
- Nippon Life-Aetna
- Starmark
- WellNet
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Amida Care
- Amida Care Medicaid
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Anthem BCBS Health Plus
- BCBS Healthplus Essential Plan 1
- BCBS Healthplus Essential Plan 2
- BCBS Healthplus Essential Plan 3
- BCBS Healthplus Essential Plan 4
- BCBS Healthplus Gatekeeper exchange
- BCBS Healthplus Mediblue Advantage
- BCBS Healthplus NY Child Health Plus NY
- BCBS Healthplus NY Medicaid Managed Care NY
- BCBS Healthplus Special Needs
- Empire Mediblue Healthplus Dual
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Anthem Blue Cross Blue Shield
- Anthem BCBS CT PPO
- Anthem BCBS CT Pathway PPO
- BCBS Blue Access EPO Large Group
- BCBS Blue Access EPO Small Group
- BCBS Blue Access GEPO Small Group
- BCBS Blue Access PPO Large Group
- BCBS EPO
- BCBS EPO (BlackRock Employees)
- BCBS EPO (LICH Employees)
- BCBS EPO - Empire EPO (NYU Langone Employees)
- BCBS EPO - Empire EPO (Sunset Park/Family Health Center Employees)
- BCBS EPO - Empire NYU Care (NYU Langone Employees)
- BCBS EPO - Empire NYU Care (Sunset Park/Family Health Center Employees)
- BCBS Federal Program
- BCBS Florida Blue Care HMO
- BCBS Florida Blue Medicare PPO
- BCBS Florida Blue Options PPO
- BCBS Florida Blue Select
- BCBS Florida MyBlue HMO
- BCBS Florida Simply Blue
- BCBS Florida Traditional PPC
- BCBS HMO
- BCBS Indemnity
- BCBS Local 32BJ Employees
- BCBS Mediblue Medicare HMO
- BCBS Mediblue Medicare PPO
- BCBS Mediblue Select HMO/Extra HMO
- BCBS POS
- BCBS PPO
- BCBS PPO (BlackRock Employees)
- BCBS PPO (LICH Employees)
- BCBS PPO - Empire PPO (Sunset Park/Family Health Center Employees)
- BCBS PPO/EPO Small Group
- New York Hotel Trades
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Centers Plan For Healthy Living
- Centers Plan For Healthy Living
- Centers Plan For Healthy Living Medicaid Advantage Plus HMO D-SNP
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Cigna
- Apwu Health Plan
- Cigna - Humana
- Cigna Great West PPO
- Cigna HMO
- Cigna Indemnity
- Cigna Managed Care/POS
- Cigna Medicare Advantage
- Cigna NALC
- Cigna Open Access
- Cigna Open Access PPO
- Cigna Oscar
- Cigna PPO
- Cigna Premier Plus
- Great West HMO
- Kaiser Permanente
- MVP-Cigna Network
- Wellfleet-NYU Student
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Connecticare
- Connecticare Bridge
- Connecticare Commercial
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Elderplan
- Elderplan
- Elderplan FIDA
- Elderplan Medicare Advantage Plan
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Emblem
- Emblem Select Care Bronze Small Group
- Emblem Select Care EPO
- Emblem Select Care Gold Small Group
- Emblem Select Care HMO
- Emblem Select Care PPO
- Emblem Select Care Platinum Small Group
- Emblem Select Care Silver Small Group
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Fidelis Care
- Ambetter Fidelis Care Bronze Exchange
- Ambetter Fidelis Care Catastrophic Cvg Exchange
- Ambetter Fidelis Care Gold Exchange
- Ambetter Fidelis Care Native American Exchange
- Ambetter Fidelis Care Platinum Exchange
- Ambetter Fidelis Care Silver Exchange
- Fidelis Care Child Health Plus
- Fidelis Care Medicaid Managed Care
- Fidelis Essential Plan 1
- Fidelis Essential Plan 2
- Fidelis Essential Plan 3
- Fidelis Essential Plan 4
- Wellcare by Fidelis Care Medicare
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First Health
- First Health PPO
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GHI
- American Plan Administrators
- GHI CBP (City of New York Employees)
- GHI Emblem Health EPO
- GHI Emblem Health PPO
- GHI HMO
- GHI HMO Medicare
- GHI Medicare PPO
- GHI Medicare Supplement
- GHI Network Access - Benefit Services of PA
- GHI Network Access - Humana
- GHI Network Access - Total Plan Concepts
- IUOE Local 14-14B
- Wlny-TV Inc.
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HIP
- Emblem Essential Plan 1
- Emblem Essential Plan 2
- Emblem Essential Plan 3
- Emblem Essential Plan 4
- HIP Access I
- HIP Access II
- HIP Bridge
- HIP Child Health Plus
- HIP EPO
- HIP HMO
- HIP Medicaid Enhanced Care
- HIP Medicare Supplement
- HIP POS
- HIP PPO
- HIP Prime Basic Exchange
- HIP Prime Bronze
- HIP Prime Bronze Exchange
- HIP Prime Catastrophic Exchange
- HIP Prime Gold
- HIP Prime Gold Exchange
- HIP Prime Platinum
- HIP Prime Platinum Exchange
- HIP Prime Silver
- HIP Prime Silver Exchange
- HIP VIP Medicare Bold
- HIP VIP Medicare Prime
- Vytra HMO
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Healthfirst
- Health And Recovery Plan (Harp)
- Healthfirst Bronze Leaf Exchange
- Healthfirst Bronze Total, Pro, Plus EPO
- Healthfirst Child Health Plus
- Healthfirst Essential Plan 1 & 2
- Healthfirst Essential Plan 3 & 4
- Healthfirst Gold Leaf Exchange
- Healthfirst Gold Total, Pro, Plus EPO
- Healthfirst Green Leaf Exchange
- Healthfirst Medicaid
- Healthfirst Medicare
- Healthfirst Medicare/NYU Risk
- Healthfirst Personal Wellness Plan
- Healthfirst Platinum Leaf Exchange
- Healthfirst Platinum Total, Pro, Plus EPO
- Healthfirst Silver Leaf Exchange
- Healthfirst Silver Total, Pro, Plus EPO
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Hotel Trades Council
- Hotel Trades Council
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Humana
- Humana Medicare Advantage
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Local 1199
- Local 1199 - NYU Hospital Member Choice
- Local 1199 PPO
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Magnacare
- Magnacare PPO
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Medicaid of New Jersey - Molina
- Medicaid NJ/Molina
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Medicaid of New York
- NYS Medicaid
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Medicare
- Medicare Part A and B
- Medicare Part B
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MetroPlusHealth
- MetroPlusHealth Bronze Plus Plan Exchange
- MetroPlusHealth Child Health Plus
- MetroPlusHealth Essential Plan 1 and 2
- MetroPlusHealth Essential Plan 3 and 4
- MetroPlusHealth Gold
- MetroPlusHealth Gold Plus Plan Exchange
- MetroPlusHealth Goldcare
- MetroPlusHealth Medicaid Managed Care
- MetroPlusHealth Medicare
- MetroPlusHealth Medplus Plan Exchange
- MetroPlusHealth Platinum Plus Plan Exchange
- MetroPlusHealth Silver Plus Plan Exchange
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Multiplan
- AXA Assistance USA
- Administrative Concepts
- Beech Street PPO
- Diversified Administration Corporation
- Fiserv Health
- GEHA
- Global Excel
- Global Health
- Guardian Life Insurance Co Of America
- Health Net Of California
- Health Republic Of NJ
- Insurance Design Administrators
- Kaiser Foundation
- Kaiser Permanente
- Meritain Health
- Multiplan PPO
- Multiplan-Capital Dist Phys Health
- Mutual Of Omaha
- Nippon Life Ins Co
- PHCS
- Professional Benefit Admin
- Qualcare Inc
- Screen Actors Guild
- Teamsters Allied Benefits
- US Life Insurance Company
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NYSHIP - The Empire Plan
- NYS Health Insurance Plan - The Empire Plan, Excelsior Plan, NY Student Employee Health Plan
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Oxford
- Oxford Health Plans Freedom
- Oxford Health Plans Liberty
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POMCO Insurance Company
- POMCO Insurance Company
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Partners Health Plan Inc
- Partners Health Plan FIDA
- Partners Health Plan Medicaid
- Partners Health Plan Medicare
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Qualcare Inc.
- Qualcare Direct
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Railroad Medicare
- Palmetto GBA Railroad Medicare
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River Spring Health Plan
- River Spring Medicare HMP SNP
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Sedgwick WTC
- World Trade Center - Sedgwick
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Senior Whole Health
- Senior Whole Health Medicare Advantage
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Tricare
- TriWest
- Tricare
- US Family Health Plan
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United Healthcare
- AARP Medicare Complete
- Bind Benefits inc
- Oxford Health Plans Medicare Advantage
- UMR
- United Healthcare (NY University Care Plan)
- United Healthcare AARP
- United Healthcare All Savers
- United Healthcare Choice
- United Healthcare Choice (AMEX employees)
- United Healthcare Choice (Blackrock employees)
- United Healthcare Choice (CBS employees)
- United Healthcare Choice (Simon
- United Healthcare EPO
- United Healthcare EPO (NYU Langone Health Employees)
- United Healthcare Golden Rule Insurance
- United Healthcare HMO
- United Healthcare Healthscope
- United Healthcare Indemnity
- United Healthcare Indemnity (NYU Langone Health Employees)
- United Healthcare Medicare
- United Healthcare Navigate
- United Healthcare Nexus
- United Healthcare Nexus (Amex Employees)
- United Healthcare POS
- United Healthcare PPO
- United Healthcare Plus (NYU Langone Health Employees)
- United Healthcare Student Resources
- United Healthcare Student Resources (NYU)
- United Healthcare Value, Advantage and HDHP (New York University employees)
- UnitedHealthcare Choice (NY Power Authority Employees)
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VA Community Care Network
- VA CCN Optum
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VNS Choice Advantage
- VNS Medicare Advantage
- VNS NY Choice Select Health
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Village Care
- VillageCare
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WTC Health Program
- NY Fire Department - WTC
- WTC Health Program
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Wellcare
- WellCare Medicare
John G. Pappas, MD does not accept insurance.
Locations and Appointments
Center for Children-Genetics Clinic
301 East 17th Street, 3rd Floor, New York, NY 10003
NYU Pediatric Genetics Associates
160 East 32nd Street, 2nd Floor, New York, NY 10016
Research My Research
Interests
SETD2, Phenotype-Genotype correlation
Clinical Trials and Research Studies
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Learn More
Registry for SETD2 Neurodevelopmental Disorder
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Learn More
Genetic evaluation of patients with undiagnosed diseases
Publications
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Cali, Elisa; Quirin, Tania; Rocca, Clarissa; Efthymiou, Stephanie; Riva, Antonella; Marafi, Dana; Zaki, Maha S; Suri, Mohnish; Dominguez, Roberto; Elbendary, Hasnaa M; Alavi, Shahryar; Abdel-Hamid, Mohamed S; Morsy, Heba; Mau-Them, Frederic Tran; Nizon, Mathilde; Tesner, Pavel; Ryba, Lukáš; Zafar, Faisal; Rana, Nuzhat; Saadi, Nebal W; Firoozfar, Zahra; Gencpinar, Pinar; Unay, Bulent; Ustun, Canan; Bruel, Ange-Line; Coubes, Christine; Stefanich, Jennifer; Sezer, Ozlem; Agolini, Emanuele; Novelli, Antonio; Vasco, Gessica; Lettori, Donatella; Milh, Mathieu; Villard, Laurent; Zeidler, Shimriet; Opperman, Henry; Strehlow, Vincent; Issa, Mahmoud Y; El Khassab, Hebatallah; Chand, Prem; Ibrahim, Shahnaz; Nejad-Rashidi, Ali; Miryounesi, Mohammad; Larki, Pegah; Morrison, Jennifer; Cristian, Ingrid; Thiffault, Isabelle; Bertsch, Nicole L; Noh, Grace J; Pappas, John; Moran, Ellen; Marinakis, Nikolaos M; Traeger-Synodinos, Joanne; Hosseini, Susan; Abbaszadegan, Mohammad Reza; Caumes, Roseline; Vissers, Lisenka E L M; Neshatdoust, Maedeh; Montazer, Mostafa Zohour; El Fahime, Elmostafa; Canavati, Christin; Kamal, Lara; Kanaan, Moien; Askander, Omar; Voinova, Victoria; Levchenko, Olga; Haider, Shahzhad; Halbach, Sara S; Maia, Elias Rayana; Mansoor, Salehi; Vivek, Jain; Tawde, Sanjukta; Santhosh R Challa, Viveka; Gowda, Vykuntaraju K; Srinivasan, Varunvenkat M; Victor, Lucas Alves; Pinero-Banos, Benito; Hague, Jennifer; Ei-Awady, Heba Ahmed; Maria de Miranda Henriques-Souza, Adelia; Cheema, Huma Arshad; Anjum, Muhammad Nadeem; Idkaidak, Sara; Alqarajeh, Firas; Atawneh, Osama; Mor-Shaked, Hagar; Harel, Tamar; Zifarelli, Giovanni; Bauer, Peter; Kok, Fernando; Kitajima, Joao Paulo; Monteiro, Fabiola; Josahkian, Juliana; Lesca, Gaetan; Chatron, Nicolas; Ville, Dorothe; Murphy, David; Neul, Jeffrey L; Mullegama, Sureni V; Begtrup, Amber; Herman, Isabella; Mitani, Tadahiro; Posey, Jennifer E; Tay, Chee Geap; Javed, Iram; Carr, Lucinda; Kanani, Farah; Beecroft, Fiona; Hane, Lee; Abdelkreem, Elsayed; Macek, Milan; Bispo, Luciana; Elmaksoud, Marwa Abd; Hashemi-Gorji, Farzad; Pehlivan, Davut; Amor, David J; Jamra, Rami Abou; Chung, Wendy K; Ghayoor, Eshan Karimiani; Campeau, Philippe; Alkuraya, Fowzan S; Pagnamenta, Alistair T; Gleeson, Joseph; Lupski, James R; Striano, Pasquale; Moreno-De-Luca, Andres; Lafontaine, Denis L J; Houlden, Henry; Maroofian, Reza
Genetics in medicine. 2024 Sep 10; 101251
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Cuccurullo, Claudia; Cerulli Irelli, Emanuele; Ugga, Lorenzo; Riva, Antonella; D'Amico, Alessandra; Cabet, Sara; Lesca, Gaetan; Bilo, Leonilda; Zara, Federico; Iliescu, Catrinel; Barca, Diana; Fung, France; Helbig, Katherine; Ortiz-Gonzalez, Xilma; Schelhaas, Helenius J; Willemsen, Marjolein H; van der Linden, Inge; Canafoglia, Laura; Courage, Carolina; Gommaraschi, Samuele; Gonzalez-Alegre, Pedro; Bardakjian, Tanya; Syrbe, Steffen; Schuler, Elisabeth; Lemke, Johannes R; Vari, Stella; Roende, Gitte; Bak, Mads; Huq, Mahbulul; Powis, Zoe; Johannesen, Katrine M; Hammer, Trine Bjørg; Møller, Rikke S; Rabin, Rachel; Pappas, John; Zupanc, Mary L; Zadeh, Neda; Cohen, Julie; Naidu, Sakkubai; Krey, Ilona; Saneto, Russell; Thies, Jenny; Licchetta, Laura; Tinuper, Paolo; Bisulli, Francesca; Minardi, Raffaella; Bayat, Allan; Villeneuve, Nathalie; Molinari, Florence; Salimi Dafsari, Hormos; Moller, Birk; Le Roux, Marie; Houdayer, Clara; Vecchi, Marilena; Mammi, Isabella; Fiorini, Elena; Proietti, Jacopo; Ferri, Sofia; Cantalupo, Gaetano; Battaglia, Domenica Immacolata; Gambardella, Maria Luigia; Contaldo, Ilaria; Brogna, Claudia; Trivisano, Marina; De Dominicis, Angela; Bova, Stefania Maria; Gardella, Elena; Striano, Pasquale; Coppola, Antonietta
Epilepsia. 2024 Sep ; 65(9):2728-2750
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Werren, Elizabeth A; Peirent, Emily R; Jantti, Henna; Guxholli, Alba; Srivastava, Kinshuk Raj; Orenstein, Naama; Narayanan, Vinodh; Wiszniewski, Wojciech; Dawidziuk, Mateusz; Gawlinski, Pawel; Umair, Muhammad; Khan, Amjad; Khan, Shahid Niaz; Geneviève, David; Lehalle, Daphné; van Gassen, K L I; Giltay, Jacques C; Oegema, Renske; van Jaarsveld, Richard H; Rafiullah, Rafiullah; Rappold, Gudrun A; Rabin, Rachel; Pappas, John G; Wheeler, Marsha M; Bamshad, Michael J; Tsan, Yao-Chang; Johnson, Matthew B; Keegan, Catherine E; Srivastava, Anshika; Bielas, Stephanie L
Cell death & disease. 2024 May 30; 15(5):379
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