All locations are open for appointments and procedures, including COVID-19 testing. Schedule an appointment online or call your doctor’s office. Patients may be accompanied by visitors. Read our updated visitor policy.

If you need help accessing our website, call 855-698-9991
Skip to main content
NYU Langone Provider

David Zagzag, MD, PhD

NYU Langone Provider
  • Specialties: Anatomic Pathology, Neuropathology
  • Languages: English, French
  • Phone: 212-263-5470
View Locations

Positions
Board Certifications
  • American Board of Pathology - Recertification, 2013
  • American Board of Pathology - Anatomic Pathology, 1993
  • American Board of Pathology (Neuropathology), 1993
Education and Training
  • Fellowship, NYU Medical Center, Neuropathology, 1992
  • Residency, NYU Medical Center, Surgical Pathology, 1990
  • PhD from McGill University, 1988

Is this your profile?

Edit profile

This provider accepts the following insurance plans.

  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna Medicare
    • Aetna POS
    • Aetna PPO/EPO
  • Agewell
    • Agewell
  • Amidacare
    • Amidacare
  • Beech Street
    • Beech Street PPO
  • Cigna
    • Cigna EPO/POS
    • Cigna PPO
  • ElderPlan
    • ElderPlan
  • Emblem
    • Emblem Select Care Exchange
  • Empire Blue Cross Blue Shield
    • Empire Blue Cross Blue Shield EPO
    • Empire Blue Cross Blue Shield HMO
    • Empire Blue Cross Blue Shield HealthPlus
    • Empire Blue Cross Blue Shield HealthPlus Essential
    • Empire Blue Cross Blue Shield Indemnity
    • Empire Blue Cross Blue Shield MediBlue
    • Empire Blue Cross Blue Shield POS
    • Empire Blue Cross Blue Shield PPO
  • Fidelis
    • Fidelis Child Health
    • Fidelis Essential
    • Fidelis Exchange
    • Fidelis Medicaid
    • Fidelis Medicare
  • GHI
    • GHI CBP
    • GHI HMO
View All Accepted Plans This list of insurances changes regularly, and insurance plans listed may not be accepted at all office locations for this provider. Before your appointment, please confirm with your insurance company that this provider accepts your insurance.

Locations and Appointments

NYU Pathology Associates

550 1st Avenue, Suite TH461
New York, NY 10016

Interests

mechanisms of cerebral vasculogenesis and angiogenesis

Research Summary

Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive vascular network is established from multipotential mesenchymal progenitors, and angiogenesis, in which preexisting vessels (both in embryo and adult) send out capillary sprouts to produce new vessels. Angiogenesis and vasculogenesis as previously defined, are crucial process in both neural embryogenesis and neoplasia. Several angiogenic and vasculogenic factors and extracellular matrix (ECM) proteins have been implicated in the development and maturation of the central nervous system (CNS) and in the biology of brain tumors. The interaction between ECM components and these factors plays an important role in every step of the angiogenic and vasculogenic cascades. Our interest is in elucidating the expression patterns, trigger mechanisms, pathophysiological and molecular mechanisms that are related to the expression of both vasculogenic and angiogenic factors and ECM proteins.

Recently, we have focused our investigations on an ECM molecule, tenascin (TN). TN is a large complex protein of the ECM which is expressed in developing brain, cartilage and mesenchyme and is re-expressed in tumors, wound healing and inflammation. It is believed to be important for several cellular processes including cell adhesion, migration, and proliferation. In contrast to the low levels of TN found in normal adult brain, enhanced expression occurs in CNS embryogenesis and human astrocytomas. In situ hybridization of astrocytomas detects strong staining for TN mRNA in vascular cells, especially in hyperplastic vessels, including those at the invasive edge of the tumors, but not in normal brain vessels.

Tie-1 and Tie-2, two receptor tyrosine kinases, and their ligands angiopoetins have recently been described and are critical for vasculogenesis. We are currently investigating how these might be implicated in brain neoplasms.

 

 

These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
Loading...
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

  • Mac Grory, Brian; Emmer, Bart J; Roosendaal, Stefan D; Zagzag, David; Yaghi, Shadi; Nossek, Erez

    Journal of neurology neurosurgery & psychiatry. 2020 Oct 01;

  • Haynes, Joseph; Raz, Eytan; Tanweer, Omar; Shapiro, Maksim; Esparza, Rogelio; Zagzag, David; Riina, Howard A; Henderson, Christine; Lillemoe, Kaitlyn; Zhang, Cen; Rostanski, Sara; Yaghi, Shadi; Ishida, Koto; Torres, Jose; Mac Grory, Brian; Nossek, Erez

    Journal of neurosurgery. 2020 Aug 28; 1-8

  • Dogra, Siddhant; Jain, Rajan; Cao, Meng; Bilaloglu, Seda; Zagzag, David; Hochman, Sarah; Lewis, Ariane; Melmed, Kara; Hochman, Katherine; Horwitz, Leora; Galetta, Steven; Berger, Jeffrey

    Journal of stroke & cerebrovascular diseases. 2020 Aug ; 29(8):104984

Read All Publications (210)