Credentials
Positions
- Professor, Department of Pathology at NYU Grossman School of Medicine
- Professor, Department of Neurosurgery at NYU Grossman School of Medicine
- Chief Division of Neuropathology
- Dir Human Brain Tumor Bank
- Director Microvascular and Molecular Neuro-Oncology Laboratory
Board Certifications
- American Board of Pathology - Recertification, 2013
- American Board of Pathology (Neuropathology), 1993
- American Board of Pathology - Anatomic Pathology, 1993
Education and Training
- Fellowship, NYU Medical Center, Neuropathology, 1992
- Residency, NYU Medical Center, Surgical Pathology, 1990
- PhD from McGill University, 1988
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Edit profileInsurance Plans Accepted
This provider accepts the following insurance plans.
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Aetna
- Aetna HMO
- Aetna Indemnity
- Aetna Medicare
- Aetna POS
- Aetna PPO/EPO
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Agewell
- Agewell
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Amidacare
- Amidacare
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Beech Street
- Beech Street PPO
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Cigna
- Cigna EPO/POS
- Cigna PPO
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ElderPlan
- ElderPlan
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Emblem
- Emblem Select Care Exchange
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Empire Blue Cross Blue Shield
- Empire Blue Cross Blue Shield EPO
- Empire Blue Cross Blue Shield HMO
- Empire Blue Cross Blue Shield HealthPlus
- Empire Blue Cross Blue Shield HealthPlus Essential
- Empire Blue Cross Blue Shield Indemnity
- Empire Blue Cross Blue Shield MediBlue
- Empire Blue Cross Blue Shield POS
- Empire Blue Cross Blue Shield PPO
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Fidelis
- Fidelis Child Health
- Fidelis Essential
- Fidelis Exchange
- Fidelis Medicaid
- Fidelis Medicare
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GHI
- GHI CBP
- GHI HMO
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HIP
- HIP Access I
- HIP Access II
- HIP Child Health
- HIP EPO/PPO
- HIP Essential
- HIP HMO
- HIP Medicaid
- HIP Medicare
- HIP POS
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HealthSmart
- HealthSmart (WTC)
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Healthfirst
- Healthfirst
- Healthfirst Essential
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Hotel Trades
- Hotel Trades
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Humana
- Humana Medicare
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Local 1199
- Local 1199 PPO
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MagnaCare
- MagnaCare PPO
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Medicare
- Medicare
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MetroPlus
- MetroPlus Child Health
- MetroPlus Essential
- MetroPlus Exchange Plans
- MetroPlus Medicaid
- MetroPlus Medicare
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MultiPlan
- MultiPlan/PHCS PPO
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MultiPlan/PHCS
- MultiPlan/PHCS PPO
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NYS Health Insurance Plan
- The Empire Plan
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Oxford
- Oxford Freedom
- Oxford Liberty
- Oxford Medicare
- Oxford Mosaic
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Railroad Medicare
- Railroad Medicare
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Senior Whole Health
- Senior Whole Health
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Tricare
- Tricare
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UHC
- UnitedHealthcare EPO
- UnitedHealthcare HMO
- UnitedHealthcare Medicare
- UnitedHealthcare POS
- UnitedHealthcare PPO
- UnitedHealthcare Top Tier
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VNS
- Visiting Nurse Service (VNS) Medicare
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Village Caremax
- Village Caremax
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WellCare
- WellCare Medicare
David Zagzag, MD, PhD does not accept insurance.
Locations and Appointments
NYU Pathology Associates
550 1st Avenue, Suite TH461, New York, NY 10016
Research My Research
Interests
mechanisms of cerebral vasculogenesis and angiogenesis
Research Summary
Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive vascular network is established from multipotential mesenchymal progenitors, and angiogenesis, in which preexisting vessels (both in embryo and adult) send out capillary sprouts to produce new vessels. Angiogenesis and vasculogenesis as previously defined, are crucial process in both neural embryogenesis and neoplasia. Several angiogenic and vasculogenic factors and extracellular matrix (ECM) proteins have been implicated in the development and maturation of the central nervous system (CNS) and in the biology of brain tumors. The interaction between ECM components and these factors plays an important role in every step of the angiogenic and vasculogenic cascades. Our interest is in elucidating the expression patterns, trigger mechanisms, pathophysiological and molecular mechanisms that are related to the expression of both vasculogenic and angiogenic factors and ECM proteins.
Recently, we have focused our investigations on an ECM molecule, tenascin (TN). TN is a large complex protein of the ECM which is expressed in developing brain, cartilage and mesenchyme and is re-expressed in tumors, wound healing and inflammation. It is believed to be important for several cellular processes including cell adhesion, migration, and proliferation. In contrast to the low levels of TN found in normal adult brain, enhanced expression occurs in CNS embryogenesis and human astrocytomas. In situ hybridization of astrocytomas detects strong staining for TN mRNA in vascular cells, especially in hyperplastic vessels, including those at the invasive edge of the tumors, but not in normal brain vessels.
Tie-1 and Tie-2, two receptor tyrosine kinases, and their ligands angiopoetins have recently been described and are critical for vasculogenesis. We are currently investigating how these might be implicated in brain neoplasms.
Research Interests Timeline
Publications
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Garcia, Mekka R; Feng, Yang; Vasudevaraja, Varshini; Galbraith, Kristyn; Serrano, Jonathan; Thomas, Cheddhi; Radmanesh, Alireza; Hidalgo, Eveline T; Harter, David H; Allen, Jeffrey C; Gardner, Sharon L; Osorio, Diana S; William, Christopher M; Zagzag, David; Boué, Daniel R; Snuderl, Matija
Journal of neuropathology & experimental neurology. 2022 Oct 18; 81(11):865-872
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Cui, Xin; Tan Morales, Renee-Tyler; Qian, Weiyi; Wang, Haoyu; Gagner, Jean-Pierre; Dolgalev, Igor; Placantonakis, Dimitris; Zagzag, David; Cimmino, Luisa; Snuderl, Matija; Lam, Raymond H W; Chen, Weiqiang
Biomaterials. 2022 Jul 04; 287:121667
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Huang, Li; Fatterpekar, Girish; Charles, Stephanie; Golub, Danielle; Zagzag, David; Agrawal, Nidhi
World neurosurgery. 2022 May ; 161:e274-e281