About Me
Conditions and Treatments
Treatments
- post covid-19 care
Credentials
Positions
- Associate Professor, Department of Medicine at NYU Grossman School of Medicine
- Associate Professor, Department of Cell Biology at NYU Grossman School of Medicine
Board Certifications
- American Board of Internal Medicine (Critical Care Medicine), 1991
- American Board of Internal Medicine (Pulmonary Disease), 1990
- American Board of Internal Medicine - Internal Medicine, 1985
Education and Training
- Fellowship, Brigham & Womens Hospital, Pulmonary, Crit Care, 1991
- MD from Washington University-St Louis, 1982
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Edit profileInsurance Plans Accepted
This provider accepts the following insurance plans.
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Aetna
- Aetna HMO
- Aetna Indemnity
- Aetna International
- Aetna Medicare Advantage
- Aetna Open Access EPO
- Aetna Open Access HMO
- Aetna POS
- Aetna POS (American Express Employer)
- Aetna PPO
- Aetna Signature Administrators PPO
- Aetna Student Plan
- Allied
- Chesterfield Resources Inc
- Christian Brothers Services
- CoreSource
- Healthscope
- Nippon Life of America-Aetna
- Nippon Life-Aetna
- Starmark
- WellNet
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Blue Cross Blue Shield
- BCBS Blue Access EPO Large Group
- BCBS Blue Access EPO Small Group
- BCBS Blue Access GEPO Small Group
- BCBS Blue Access PPO Large Group
- BCBS EPO
- BCBS EPO (BlackRock Employees)
- BCBS EPO - Empire EPO (NYU Langone Employees)
- BCBS EPO - Empire EPO (Sunset Park/Family Health Center Employees)
- BCBS EPO - Empire NYU Care (NYU Langone Employees)
- BCBS EPO - Empire NYU Care (Sunset Park/Family Health Center Employees)
- BCBS Federal Program
- BCBS Florida Blue Care HMO
- BCBS Florida Blue Medicare PPO
- BCBS Florida Blue Options PPO
- BCBS Florida Blue Select
- BCBS Florida MyBlue HMO
- BCBS Florida Simply Blue
- BCBS Florida Traditional PPC
- BCBS HMO
- BCBS Indemnity
- BCBS Local 32BJ Employees
- BCBS Mediblue Medicare HMO
- BCBS Mediblue Medicare PPO
- BCBS Mediblue Select HMO/Extra HMO
- BCBS POS
- BCBS PPO
- BCBS PPO (BlackRock Employees)
- BCBS PPO (LICH Employees)
- BCBS PPO - Empire PPO (Sunset Park/Family Health Center Employees)
- BCBS PPO/EPO Small Group
- New York Hotel Trades
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Cigna
- Apwu Health Plan
- Cigna Oscar
- Cigna Great West PPO
- Cigna HMO
- Cigna Indemnity
- Cigna Managed Care/POS
- Cigna Medicare Advantage
- Cigna NALC
- Cigna Open Access
- Cigna Open Access PPO
- Cigna PPO
- Cigna Premier Plus
- Great West HMO
- Kaiser Permanente
- MVP-Cigna Network
- Wellfleet-NYU Student
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Connecticare
- Connecticare Bridge
- Connecticare Commercial
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Elderplan
- Elderplan
- Elderplan FIDA
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Emblem
- Emblem Select Care Basic Exchange
- Emblem Select Care Bronze Exchange
- Emblem Select Care Bronze Small Group
- Emblem Select Care Catastrophic Exchange
- Emblem Select Care EPO
- Emblem Select Care Gold Exchange
- Emblem Select Care Gold Small Group
- Emblem Select Care HMO
- Emblem Select Care PPO
- Emblem Select Care Platinum Exchange
- Emblem Select Care Platinum Small Group
- Emblem Select Care Silver Exchange
- Emblem Select Care Silver Small Group
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GHI
- American Plan Administrators
- GHI CBP (City of New York Employees)
- GHI Emblem Health EPO
- GHI Emblem Health PPO
- GHI HMO
- GHI HMO Medicare
- GHI Medicare PPO
- GHI Medicare Supplement
- GHI Network Access - Benefit Services of PA
- GHI Network Access - Humana
- GHI Network Access - Total Plan Concepts
- IUOE Local 14-14B
- Wlny-TV Inc.
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HIP
- HIP Access I
- HIP Access II
- HIP Bridge
- HIP Child Health Plus
- HIP EPO
- HIP HMO
- HIP Medicare Supplement
- HIP POS
- HIP PPO
- HIP Prime Basic Exchange
- HIP Prime Bronze
- HIP Prime Bronze Exchange
- HIP Prime Catastrophic Exchange
- HIP Prime Gold
- HIP Prime Platinum
- HIP Prime Platinum Exchange
- HIP Prime Silver
- HIP Prime Silver Exchange
- HIP VIP Medicare Bold
- HIP VIP Medicare Prime
- Vytra HMO
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Hamaspik Choice
- Hamaspik Choice Medicare DSNP
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Hotel Trades Council
- Hotel Trades Council
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Humana
- Humana Medicare Advantage
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Local 1199
- Local 1199 - NYU Hospital Member Choice
- Local 1199 PPO
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Longevity Health Plan
- Longevity Health Plan Medicare
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Magnacare
- Bricklayers Ins and Welfare Fund
- Magnacare PPO
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Medicare
- Medicare Part B
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Multiplan
- AXA Assistance USA
- Administrative Concepts
- Beech Street PPO
- Diversified Administration Corporation
- Fiserv Health
- GEHA
- Global Excel
- Global Health
- Guardian Life Insurance Co Of America
- Health Net Of California
- Health Republic Of NJ
- Humana Health Plan
- Insurance Design Administrators
- Kaiser Foundation
- Kaiser Permanente
- Meritain Health
- Multiplan PPO
- Multiplan-Capital Dist Phys Health
- Mutual Of Omaha
- Nippon Life Ins Co
- PHCS
- Professional Benefit Admin
- Qualcare Inc
- Screen Actors Guild
- Teamsters Allied Benefits
- US Life Insurance Company
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NYSHIP - The Empire Plan
- NYS Health Insurance Plan - The Empire Plan
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Oxford
- Oxford Health Plans Freedom
- Oxford Health Plans Liberty
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POMCO Insurance Company
- POMCO Insurance Company
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Qualcare Inc.
- Qualcare Direct
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Railroad Medicare
- Palmetto GBA Railroad Medicare
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Sedgwick WTC
- World Trade Center - Sedgwick
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Tricare
- TriWest
- Tricare
- US Family Health Plan
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United Healthcare
- AARP Medicare Complete
- Bind Benefits inc
- Oxford Health Plans Medicare Advantage
- UMR
- United Healthcare AARP
- United Healthcare All Savers
- United Healthcare Choice
- United Healthcare Choice (AMEX employees)
- United Healthcare Choice (Blackrock employees)
- United Healthcare Choice (CBS employees)
- United Healthcare EPO
- United Healthcare EPO (NYU Langone Health Employees)
- United Healthcare Golden Rule Insurance
- United Healthcare HMO
- United Healthcare Indemnity
- United Healthcare Indemnity (NYU Langone Health Employees)
- United Healthcare Medicare
- United Healthcare Navigate
- United Healthcare POS
- United Healthcare PPO
- United Healthcare Plus (NYU Langone Health Employees)
- United Healthcare Student Resources
- United Healthcare Value, Advantage and HDHP (New York University employees)
- UnitedHealthcare Choice (NY Power Authority Employees)
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VA Community Care Network
- VA CCN Optum
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VNS Choice Advantage
- VNS Medicare Advantage
- VNS NY Choice Select Health
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Village Care
- VillageCare
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WTC Health Program
- NY Fire Department - WTC
- WTC Health Program
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Wellcare
- WellCare Medicare
John S. Munger, MD does not accept insurance.
Locations and Appointments
NYU Pulmonary & Critical Care Associates
222 East 41st Street, 21st Floor, New York, NY 10017
NYU Langone Pulmonary And Critical Care Associates - 41 Street
222 East 41st Street, 17 Floor, New York, NY 10017
Research My Research
Interests
how integrins activate latent TGFβ1 and TGFβ3 during development and in disease, cancer
Research Summary
Our lab studies how latent forms of TGFβ are activated by integrins in vivo.
TGFβ is a ubiquitously produced growth factor with important roles in pathologic processes such as cancer, fibrosis and autoimmunity, and in normal development, wound repair and homeostasis. There are three TGFβ isoforms, and all are secreted in a latent form. Latency is the result of a noncovalent association of the growth factor with its propeptide, which is called latency-associate peptide (LAP). TGFβ must be released from LAP before it can bind TGFβ receptors. The activation step is highly regulated but the specific activation mechanisms involved vivo have been poorly understood.
We discovered that αvβ6, a cell surface adhesion molecule in the integrin family, can activate latent TGFβ1 and TGFβ3 by interacting with an RGD sequence in the TGFβ1 and TGFβ3 LAPs. αvβ6 is expressed in epithelia, particularly after injury. Mice lacking αvβ6 have lung inflammation and are protected from lung fibrosis due to a relative lack of TGFβ signaling in the lung.
We also collaborated with S. Nishimura's lab at UCSF to show that a second RGD-binding integrin, αvβ8, activates TGFβ1 and TGFβ3. Mice lacking this integrin have abnormalities in vascular development. Comparison of knockouts of the two TGFβs and the two β integrin subunits reveals several partially or completely overlapping abnormalities in palate closure, immune regulation, and vascular development, suggesting that αvβ6 and αvβ8 are key TGFβ1/3 activators in vivo.
To determine the role of all RGD-binding integrins in the activation of latent TGFβ1, we made mice with a knock-in mutation of the TGFβ1 gene that changes the RGD site to RGE. These mice produce normal amounts of latent TGFβ1, but it cannot be activated by RGD-binding integrins. Strikingly, the mice have the same abnormalities seen in TGFβ1-null mice, indicating that RGD-binding integrins are indispensable for TGFβ1 activation.
We are currently further exploring the connection between these two integrins and the two RGD-containing TGFβ isoforms by generating mice with combined TGFβ1/3 mutations and mice with combined αvβ6/αvβ8 deficits. Our results support a tight functional system involving the two TGFβs and the two activating integrins. For example, mice with combined αvβ6/αvβ8 deficits have completely penetrant cleft palate, and mice with combined TGFβ1/3 mutations have the CNS vascular changes seen in αvβ8-null mice.
We are now focusing on the immune phenotype of mice lacking function of both αvβ6 and αvβ8. These mice develop severe autoimmune reactions that appear identical to (if not more severe than) those of TGFβ1-null mice. Also, we are testing the effectiveness of an inhibitory anti-αvβ6 mAb, developed by Biogen Idec, in mouse models of lung fibrosis. We find that anti-αvβ6 treatment effectively prevents radiation-induced lung fibrosis in mice, raising the possibility that such treatment might benefit patients with various forms of lung fibrosis.
Research Interests Timeline
Clinical Trials and Research Studies
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A Phase 2 Study of BIO 300 in Patients with COVID-19
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Registry of COVID-19 Survivors: Assessment of ICU and Non-ICU Survivors: A Creation of a COVID Survivorship Database
Publications
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Yie, Ting-An; Loomis, Cynthia A; Nowatzky, Johannes; Khodadadi-Jamayran, Alireza; Lin, Ziyan; Cammer, Michael; Barnett, Clea; Mezzano, Valeria; Alu, Mark; Novick, Jackson A; Munger, John S; Kugler, Matthias C
American journal of respiratory cell & molecular biology. 2023 May ; 68(5):523-536
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Chandra, Jay; Armengol de la Hoz, Miguel A; Lee, Gwendolyn; Lee, Alexandria; Thoral, Patrick; Elbers, Paul; Lee, Hyung-Chul; Munger, John S; Celi, Leo Anthony; Kaufman, David A
Critical care. 2022 Apr 11; 26(1):103
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Brosnahan, Shari B; Jonkman, Annemijn H; Kugler, Matthias C; Munger, John S; Kaufman, David A
Arteriosclerosis, thrombosis, & vascular biology. 2020 Sep 22; ATVBAHA120314515