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Research My Research
genomics, immunology, microbiology
Our lab is focused on understanding the adaptive changes in S. aureus that take place during infection. An integrated approach is used that incorporates new technologies to detect low abundance variants in pooled bacterial populations, traditional bacterial and evolutionary genetics, and molecular population genetic analysis. A special focus of these studies is on the identification of within-host variation in the agr locus, a global regulator of virulence in S. aureus. agr mutants are attenuated for virulence in animal models of infection, and the majority of clinical isolates have a functional agr locus. However, agr-defective strains are frequently recovered from patients with a variety of hospital-acquired infections, suggesting that the occurrence of these strains may be favored under certain in vivo conditions. This work is motivated by practical questions in infectious diseases (such as the best use of antimicrobials that target agr and virulence), as well as more basic yet closely intertwined questions, such as how to explain the alterations that are responsible for adaptive changes atdifferent stages of S. aureus infections.
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Research Interests Timeline
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Jul 02; 116(27):13563-13572
Journal of arthroplasty. 2019 May ; 34(5):954-958
Cell host & microbe. 2019 Mar 13; 25(3):463-470.e9