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Bo Shopsin at [NYU Langone Health]

Bo Shopsin, MD, PhD

  • Specialty: Infectious Diseases & Immunology
  • Language: English

Credentials

Positions
  • Saul J. Farber Assistant Professor of Medicine, Department of Medicine
  • Assistant Professor, Department of Microbiology
  • Director, Molecular Epidemiology
Education and Training
  • Fellowship, New York University, Infectious Diseases, 2006
  • Residency, New York University, Internal Medicine, 2004
  • MD from New York University, 2001
  • PhD from New York University, 2000
Departments

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Insurance Plans Accepted

Research My Research

Interests

genomics, immunology, microbiology

Research Summary

Our lab is focused on understanding the adaptive changes in S. aureus that take place during infection. An integrated approach is used that incorporates new technologies to detect low abundance variants in pooled bacterial populations, traditional bacterial and evolutionary genetics, and molecular population genetic analysis. A special focus of these studies is on the identification of within-host variation in the agr locus, a global regulator of virulence in S. aureus. agr mutants are attenuated for virulence in animal models of infection, and the majority of clinical isolates have a functional agr locus. However, agr-defective strains are frequently recovered from patients with a variety of hospital-acquired infections, suggesting that the occurrence of these strains may be favored under certain in vivo conditions. This work is motivated by practical questions in infectious diseases (such as the best use of antimicrobials that target agr and virulence), as well as more basic yet closely intertwined questions, such as how to explain the alterations that are responsible for adaptive changes atdifferent stages of S. aureus infections.

Learn more about my research

Academic Contact

Lab Website

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library. *
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Publications

  • Sause, William E; Balasubramanian, Divya; Irnov, Irnov; Copin, Richard; Sullivan, Mitchell J; Sommerfield, Alexis; Chan, Rita; Dhabaria, Avantika; Askenazi, Manor; Ueberheide, Beatrix; Shopsin, Bo; van Bakel, Harm; Torres, Victor J

    Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Jul 02; 116(27):13563-13572

  • Goodman, Susan M; Nocon, Allina A; Selemon, Nicolas A; Shopsin, Bo; Fulmer, Yi; Decker, Mary E; Grond, Sarah E; Donlin, Laura T; Figgie, Mark P; Sculco, Thomas P; Russell, Linda A; Henry, Michael E; Bass, Anne R; Miller, Andy O; Sculco, Peter K

    Journal of arthroplasty. 2019 May ; 34(5):954-958

  • Lubkin, Ashira; Lee, Warren L; Alonzo, Francis; Wang, Changsen; Aligo, Jason; Keller, Matthew; Girgis, Natasha M; Reyes-Robles, Tamara; Chan, Rita; O'Malley, Aidan; Buckley, Peter; Vozhilla, Nikollaq; Vasquez, Marilyn T; Su, Johnny; Sugiyama, Michael; Yeung, Stephen T; Coffre, Maryaline; Bajwa, Sofia; Chen, Eric; Martin, Patricia; Kim, Sang Y; Loomis, Cynthia; Worthen, G Scott; Shopsin, Bo; Khanna, Kamal M; Weinstock, Daniel; Lynch, Anthony Simon; Koralov, Sergei B; Loke, P'ng; Cadwell, Ken; Torres, Victor J

    Cell host & microbe. 2019 Mar 13; 25(3):463-470.e9

Read All Publications (41)

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