Thomas M. Wisniewski, MD

About Me

Conditions and Treatments

Alzheimer's disease, cognitive disorder, dementia, lewy body dementia, memory disorders, frontotemporal dementia, prion disease, Jakob-Creutzfeldt syndrome, memory loss, cognitive impairment

Credentials

Positions
  • Lulu P. and David J. Levidow Professor of Neurology, Department of Neurology
  • Professor, Department of Pathology
  • Professor, Department of Psychiatry
  • Director, Alzheimer's Disease Center
  • Director, Center for Cognitive Neurology
  • Director, Neuropathology Fellowship
  • Director, Pearl I. Barlow Center for Memory Evaluation and Treatment
  • Director, Division of Cognitive Neurology
  • Assoc Chair for Research, Department of Neurology
Board Certifications
  • American Board of Pathology (Neuropathology), 1990
  • American Board of Psychiatry & Neurology - Neurology, 1989
Education and Training
  • Fellowship, Columbia Presbyterian Medical Center, Neuropathology, 1990
  • Residency, NYU Medical Center, 1988
  • MD from University Of London, 1983

Locations and Appointments

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  • Aetna
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NYU Pearl Barlow Center for Memory Evaluation and Treatment

145 East 32nd Street, 2nd Floor
New York, NY 10016

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Research My Research

Dr. Wisniewski obtained his MD at Kings College School of Medicine in the UK. He did his Neurology and Neuropathology Residencies at NYU and Columbia-Presbyterian, respectively. He is a board certified Neurologist and Neuropathologist, who runs an active research laboratory focusing on neurodegenerative disorders, in particular the mechanisms which drive amyloid deposition in Alzheimer''s and prion related diseases. This work has led to over 240 peer-reviewed publications. An important aim of his work has been to direct this greater understanding toward therapeutic interventions. Key discoveries have included discovering the role of apolipoprotein E in driving amyloid deposition in late-onset AD. Dr. Wisniewski coined the term "pathological chaperone" to denote the role of apoE, even prior to the discovery of the linkage of apoE4 to late-onset AD. Dr. Wisniewski has also been developing strategies for the enhanced clearance of pathological conformations of both amyloid beta and tau proteins in AD using non-toxic, highly immunogenic proteins as "vaccines". This approach has been shown to be highly efficacious in several animal models of AD and prion diseases. He has also been working at using this immunomodulation approach for a broader list of neurodegenerative diseases, which are called "conformational disease". His work has shown that this approach delays the onset of disease in animal models of prion infection. Recent prion related studies have focused on testing a novel mucosal vaccine in white tailed deer to prevent chronic wasting disease (CWD). CWD is an emerging, highly infectious prion disease affecting large numbers of cervids in the USA and Canada. Recent data suggests mucosal vaccination can give partial protection from CWD.

Publications

  • Human Umbilical Cord Stem Cell Xenografts Improve Cognitive Decline and Reduce the Amyloid Burden in a Mouse Model of Alzheimer's Disease

    Boutajangout, Allal; Noorwali, Abdulwahab; Atta, Hazem; Wisniewski, Thomas Boutajangout, Allal; Noorwali, Abdulwahab; Atta, Hazem; Wisniewski, Thomas
    Current Alzheimer research. 2016 Oct 4. ?-?

  • Oral vaccines for transmissible prion diseases for multiple animal species at risk of infection [Meeting Abstract]

    Goni, F; Elisei, A; Yim, L; Marta-Ariza, M; Mathiason, C; Hoover, E; Chabalgoity, JA; Wisniewski, T Goni, F; Elisei, A; Yim, L; Marta-Ariza, M; Mathiason, C; Hoover, E; Chabalgoity, JA; Wisniewski, T
    European journal of immunology. 2016 AUG. 46: 808-808

  • Anti-conformation monoclonal antibody effective in pre-clinical treatment of full Alzheimer's disease animal models by targeting pathological oligomeric forms of A beta and modified Tau [Meeting Abstract]

    Goni, F; Marta-Ariza, M; Herline, K; Boutajangout, A; Mehta, P; Drummond, E; Prelli, F; Wisniewski, T Goni, F; Marta-Ariza, M; Herline, K; Boutajangout, A; Mehta, P; Drummond, E; Prelli, F; Wisniewski, T
    European journal of immunology. 2016 AUG. 46: 1035-1035

Read All Publications (381)