Rheumatologist Bruce Cronstein, MD, the Dr. Paul R. Esserman Professor of Medicine at NYU Langone, says his team’s latest study links diminished levels of adenosine, a chemical at the heart of human cellular function, to osteoarthritis (OA), the commonplace, “wear-and-tear” form of arthritis.
Dr. Cronstein, who also serves as director of the Clinical and Translational Science Institute and chief of the Division of Translational Medicine at NYU Langone, describes how images from a dozen male research mice, survivors of Superstorm Sandy who had also stopped mating and eating, helped them find a new treatment approach for the common joint disease.
“These results support the hypothesis that maintaining extracellular adenosine levels is an important homeostatic mechanism, loss of which contributes to the development of OA,” Dr. Cronstein tells the San Diego Union-Tribune. “Targeting adenosine A2A receptors might treat or prevent OA.”
Read more from the San Diego Union Tribune.