William L. Carroll, MD

  • Specialties: Pediatric Oncology, Pediatric Hematology
  • Language: English
  • Phone: 212-263-9906

About Me

At NYU Langone’s Stephen D. Hassenfeld Children’s Center for Cancer and Blood Disorders, I treat children who have pediatric malignancies, such as leukemia and lymphoma. My personal philosophy and our team’s goal is to provide individualized treatment that fits each child.

We don’t just treat patients—we care for children and their families. We use a 360-degree approach that extends beyond medical treatment, aiming to improve diet and nutrition and reduce the psychological, social, and spiritual burden of illness. The cure rate for childhood cancers has improved dramatically, but we want children and their families to continue to live their lives as healthfully as possible, so we focus on the future from the first day of treatment.

As an oncologist involved in several national committees, I have an appreciation of where oncology is headed and how it has changed. I perform research that is funded by the National Cancer Institute and focused on discovering the molecular origins of childhood cancers. I use this research to develop better treatments and, someday, preventive measures. We are also developing precision medicine, in which we use the genetic makeup of a tumor to understand its vulnerabilities.


Conditions and Treatments

childhood cancer, leukemia, lymphoma, blood disorder, anemia, platelet disorders, pancytopenia, stem cell transplantation, acute lymphocytic leukemia (ALL), recurrent childhood acute lymphoblastic leukemia, germ cell tumor, Hodgkin disease (HD), cancer of the soft tissue, Wilms tumor, acute myelogenous leukemia (AML), neuroblastoma, bone cancer
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Credentials

Positions
  • Julie and Edward J. Minskoff Professor of Pediatrics, Department of Pediatrics
  • Professor, Department of Pathology
  • Dir Division of Pediatric Hematology/Oncology
  • Assoc Chair Clinical and Translational Research
Board Certifications
  • American Board of Pediatrics (Pediatric Hematology-Oncology), 1987
  • American Board of Pediatrics - Pediatrics, 1984
Education and Training
  • Fellowship, Stanford University Hospital, Hematology Oncology, 1987
  • Fellowship, Stanford University Hospital, Peds Hem/Oncology, 1984
  • Residency, Children's Hospital Medical Center, Pediatrics, 1982
  • MD from University Of California, 1978
Departments

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Stephen D. Hassenfeld Childrens Center for Cancer & Blood Disorders

160 East 32nd Street, 3rd Floor
New York, NY 10016

Contact

Phone: 212-263-9906

Welcome back!

As a returning patient for this doctor, please schedule an appointment using your MyChart at NYU Langone account.

Learn more about MyChart at NYU Langone.

My Research

Our laboratory is focused on two major challenges facing children with acute lymphoblastic leukemia (ALL).

First, in spite of dramatic improvements in outcome one in four children will suffer a relapse and their prognosis is poor.

Second, the "cost" of therapy for those who are cured is high with short and long term side effects. Therefore our laboratory seeks to understand mechanisms of drug resistance and to identify pathways unique to the cancer cell that can serve as targets for more effective, less toxic therapeutic approaches.

In addition we are using genomic and proteomic approaches to predict prognosis better so that therapy can be tailored to the individual patient thereby maximizing chances for cure while minimizing side effects.

We have identified gene expression profiles that predict response to therapy and are validating these signatures in an independent cohort of children currently undergoing therapy for ALL.

In addition similar efforts using expression profiling to characterize blasts at relapse has led to the provisional identification of a number of drug resistance mechanisms in ALL.

We are now using siRNA approaches to validate the functional significance of these pathways and our long term goal is to use relevant pathways as targets for therapy.

Finally we have had a long term interest in defining cell death pathways that operate in vivo and have discovered that leukemic blasts use a variety of pathways to execute apoptosis.

We hypothesize that the route of cell death correlates with response to therapy and such pathways can be modulated to favor cancer cell death thereby maximizing the therapeutic potential of conventional agents.

Our laboratory encompasses the full spectrum of investigation involving basic "bench" research, highly translational efforts using samples from patients and clinical trials in children with ALL.

Publications

  • Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

    Abrams, Rachel P; Carroll, William L; Woerpel, K A Abrams, Rachel P; Carroll, William L; Woerpel, K A
    ACS chemical biology. 2016 Mar 1. 11 (5): 1305-1312

  • Genomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient

    Bhatla, Teena; Dandekar, Smita; Lu, Benjamin Y; Wang, Jinhua; Han, Eugenia; Bitterman, Danielle; Jones, Courtney L; Evensen, Nikki A; Magid, Margret; Meyer, Julia A; Carroll, William L Bhatla, Teena; Dandekar, Smita; Lu, Benjamin Y; Wang, Jinhua; Han, Eugenia; Bitterman, Danielle; Jones, Courtney L; Evensen, Nikki A; Magid, Margret; Meyer, Julia A; Carroll, William L
    Journal of pediatric hematology/oncology. 2016 Jan . 38 (1): e21-e25

  • Therapies on the horizon for childhood acute lymphoblastic leukemia

    Carroll, William L; Hunger, Stephen P Carroll, William L; Hunger, Stephen P
    Current opinion in pediatrics. 2016 Feb . 28 (1): 12-18

Read All Publications (202)