Conditions and Treatments
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- Julie and Edward J. Minskoff Professor of Pediatrics, Department of Pediatrics
- Professor, Department of Pathology
- Dir Division of Pediatric Hematology/Oncology
- Assoc Chair Clinical and Translational Research
- AB Pediatrics (Pediatric Hematology-Oncology)
- AB Pediatrics - Pediatrics
Education and Training
- Fellowship, Stanford University Hospital, Hematology Oncology
- Fellowship, Stanford University Hospital, Peds Hem/Oncology
- Residency, Children's Hospital Medical Center, Pediatrics
- MD from University Of California
Locations and Appointments
- Aetna HMO
- Aetna Indemnity
- Aetna Medicare
- Aetna POS
- Aetna PPO/EPO
- Affinity Exchange- Essential
- Cigna EPO/POS
- Cigna PPO
- Empire Blue Cross Blue Shield EPO
- Empire Blue Cross Blue Shield HMO
- Empire Blue Cross Blue Shield Healthy NY
- Empire Blue Cross Blue Shield Indemnity
- Empire Blue Cross Blue Shield MediBlue
- Empire Blue Cross Blue Shield POS
- Empire Blue Cross Blue Shield PPO
- Empire Blue Cross Blue Shield Pathways, Enhanced
- Fidelis Child Health
- Fidelis Exchange
- Fidelis Family Health
- Fidelis Medicaid
- Fidelis Medicare
- GHI CBP
- HIP Access I
- HIP Access II
- HIP Child Health
- HIP EPO/PPO
- HIP Family Health
- HIP HMO
- HIP Medicaid
- HIP Medicare
- HIP POS
- HealthPlus Child Health (Amerigroup)
- HealthPlus Family Health (Amerigroup)
- HealthPlus Medicaid (Amerigroup)
- HealthSmart (WTC)
- Hotel Trades
- Humana Medicare
- Local 1199 PPO
- MagnaCare PPO
- MetroPlus Child Health
- MetroPlus Exchange Plans
- MetroPlus Family Health
- MetroPlus Medicaid
- MultiPlan/PHCS PPO
- NY Medicaid
- NYS Empire Plan
- Oxford Exchange
- Oxford Freedom
- Oxford Liberty
- Oxford Medicare
- UPN Elite
- United Exchange- Compass
- UnitedHealthcare Community & State Plan
- UnitedHealthcare EPO
- UnitedHealthcare HMO
- UnitedHealthcare Medicare
- UnitedHealthcare POS
- UnitedHealthcare PPO
- UnitedHealthcare Top Tier
- Visiting Nurse Service (VNS) Medicare
Stephen D. Hassenfeld Childrens Center for Cancer & Blood Disorders
160 East 32nd Street, 3rd Floor
New York, NY 10016
Childhood cancers, acute leukemia, neuroblastoma, apoptotic pathways in cancer cells, microarray analysis of childhood cancer.
Our laboratory is focused on two major challenges facing children with acute lymphoblastic leukemia (ALL).
First, in spite of dramatic improvements in outcome one in four children will suffer a relapse and their prognosis is poor.
Second, the "cost" of therapy for those who are cured is high with short and long term side effects. Therefore our laboratory seeks to understand mechanisms of drug resistance and to identify pathways unique to the cancer cell that can serve as targets for more effective, less toxic therapeutic approaches.
In addition we are using genomic and proteomic approaches to predict prognosis better so that therapy can be tailored to the individual patient thereby maximizing chances for cure while minimizing side effects.
We have identified gene expression profiles that predict response to therapy and are validating these signatures in an independent cohort of children currently undergoing therapy for ALL.
In addition similar efforts using expression profiling to characterize blasts at relapse has led to the provisional identification of a number of drug resistance mechanisms in ALL.
We are now using siRNA approaches to validate the functional significance of these pathways and our long term goal is to use relevant pathways as targets for therapy.
Finally we have had a long term interest in defining cell death pathways that operate in vivo and have discovered that leukemic blasts use a variety of pathways to execute apoptosis.
We hypothesize that the route of cell death correlates with response to therapy and such pathways can be modulated to favor cancer cell death thereby maximizing the therapeutic potential of conventional agents.
Our laboratory encompasses the full spectrum of investigation involving basic "bench" research, highly translational efforts using samples from patients and clinical trials in children with ALL.
Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3)Dreyer, ZoAnn E; Hilden, Joanne M; Jones, Tamekia L; Devidas, Meenakshi; Winick, Naomi J; Willman, Cheryl L; Harvey, Richard C; Chen, I-Ming; Behm, Fred G; Pullen, Jeanette; Wood, Brent L; Carroll, Andrew J; Heerema, Nyla A; Felix, Carolyn A; Robinson, Blaine; Reaman, Gregory H; Salzer, Wanda L; Hunger, Stephen P; Carroll, William L; Camitta, Bruce M 2015 Mar; 419-426, Pediatric blood & cancer — id: 1477622, year: 2015, page: 419, stat: Journal Article
Re-induction chemoimmunotherapy with epratuzumab in relapsed acute lymphoblastic leukemia (ALL): Phase II results from Children's Oncology Group (COG) study ADVL04P2Raetz, Elizabeth A; Cairo, Mitchell S; Borowitz, Michael J; Lu, Xiaomin; Devidas, Meenakshi; Reid, Joel M; Goldenberg, David M; Wegener, William A; Zeng, Hui; Whitlock, James A; Adamson, Peter C; Hunger, Stephen P; Carroll, William L 2015 Mar; e506-e514, Pediatric blood & cancer — id: 1480422, year: 2015, page: e506, stat: JOURNAL ARTICLE
Safe integration of nelarabine into intensive chemotherapy in newly diagnosed T-cell acute lymphoblastic leukemia: Children's Oncology Group Study AALL0434Winter, Stuart S; Dunsmore, Kimberly P; Devidas, Meenakshi; Eisenberg, Nancy; Asselin, Barbara L; Wood, Brent L; Leonard Rn, Marcia S; Murphy, John; Gastier-Foster, Julie M; Carroll, Andrew J; Heerema, Nyla A; Loh, Mignon L; Raetz, Elizabeth A; Winick, Naomi J; Carroll, William L; Hunger, Stephen P 2015 Mar; 542-543, Pediatric blood & cancer — id: 1494742, year: 2015, page: 542, stat: JOURNAL ARTICLE