Jill P. Buyon, MD

  • Specialty: Rheumatology
  • Language: English
  • Phone: 646-501-7400

About Me

Conditions and Treatments

rheumatism, lupus erythematosus, systemic lupus erythematosus (SLE), sicca syndrome

Credentials

Positions
  • Lady Va and Sir Deryck Maughan Professor of Rheumatology, Department of Medicine
  • Dir Division of Rheumatology
  • Dir Lupus Center
Board Certifications
  • American Board of Internal Medicine (Rheumatology), 1984
  • American Board of Internal Medicine - Internal Medicine, 1981
Education and Training
  • Fellowship, Hospital For Joint Diseases, Molecular Biology, 1986
  • Fellowship, NYU Medical Center, Rheumatology, 1983
  • Residency, Bronx Municipal Hospital Cntr, Internal Medicine, 1981
  • MD from Albert Einstein College Of Med, 1978
Departments

Locations and Appointments

View Insurance Plans Accepted
  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna International
    • Aetna Medicare Managed Care
    • Aetna Meritain Health
    • Aetna Open Access Elect Choice (EPO)
    • Aetna Open Access HMO
    • Aetna POS
    • Aetna PPO
    • Aetna Student Health
    • Chesterfield Resources Inc
    • Christian Brothers Services
    • CoreSource
    • Nippon Life Of America - Aetna
    • Nippon Life-Aetna
    • Starmark
    • WellNet
  • BCBS Out of State
    • BCBS Out/State Medicare
    • BCBS Out/State EPO
    • BCBS Out/State HMO
    • BCBS Out/State Indemnity
    • BCBS Out/State POS
    • BCBS Out/State PPO
  • Blue Cross Blue Shield
    • BCBS Bronze Guided Access Exchange
    • BCBS Bronze Guided Access HSA Exchange
    • BCBS Catastrophic Guided Access Exchange
    • BCBS Child Health Plus
    • BCBS EPO
    • BCBS Federal Program
    • BCBS Global Transplants
    • BCBS Gold Guided Access Exchange
    • BCBS HMO
    • BCBS Healthy New York
    • BCBS Indemnity
    • BCBS Mediblue Medicare HMO
    • BCBS Mediblue Medicare PPO
    • BCBS Open Access PPO (Hb Only)
    • BCBS POS
    • BCBS PPO
    • BCBS Pathway
    • BCBS Pathway Enhanced
    • BCBS Pathway X Enhanced
    • BCBS Platinum Guided Access Exchange
    • BCBS Silver Guided Access Exchange
    • BCBS Silver Guided Access HSA Exchange
    • Local 32BJ SEIU
    • Unicare
  • Carecore
    • CareCore Aetna
    • CareCore HIP Medicaid
  • Champva
    • Champva
  • GHI
    • GHI Medicare Supplement
  • HIP
    • HIP Medicaid
    • HIP Medicaid (Healthcare Partners)
    • HIP Medicaid (Montefiore)
    • HIP Medicare (Healthcare Partners)
  • Health Smart
    • WTC Health Program-HHC
    • WTC Health Program-Mt. Sinai
    • WTC Health Program-NYU
    • WTC Health Program-North Shore
    • WTC Health Program-Stonybrook
    • WTC Health Program-UMDNY/Rutgers
    • WTC-FDNY
  • Healthfirst
    • Health And Recovery Plan (Harp)
    • Health And Recovery Plan (Harp)- Nyu Risk
    • Healthfirst 65 Plus Plan (HMO)
    • Healthfirst 65- Nyu Risk
    • Healthfirst Absolute Care FIDA
    • Healthfirst Absolute Care FIDA- NYU Risk
    • Healthfirst Assured Care
    • Healthfirst Assured Care- NYU Risk
    • Healthfirst Bronze Leaf Exchange
    • Healthfirst Bronze Leaf Exchange- NYU Risk
    • Healthfirst Child Health Plus
    • Healthfirst Child Health Plus- NYU Risk
    • Healthfirst Complete Care
    • Healthfirst Complete Care- NYU Risk
    • Healthfirst Coordinated Benefits Plan (HMO)
    • Healthfirst Coordinated Benefits Plan- NYU Risk
    • Healthfirst Essential Plan 1
    • Healthfirst Essential Plan 1- NYU Risk
    • Healthfirst Essential Plan 2
    • Healthfirst Essential Plan 2- NYU Risk
    • Healthfirst Essential Plan 3
    • Healthfirst Essential Plan 3- NYU Risk
    • Healthfirst Essential Plan 4
    • Healthfirst Essential Plan 4- NYU Risk
    • Healthfirst Gold Leaf Exchange
    • Healthfirst Gold Leaf Exchange- NYU Risk
    • Healthfirst Green Leaf Exchange
    • Healthfirst Green Leaf Exchange- NYU Risk
    • Healthfirst Health New York
    • Healthfirst Health New York- NYU Risk
    • Healthfirst Increased Benefits Plan
    • Healthfirst Increased Benefits Plan- NYU Risk
    • Healthfirst Life Improved Plan
    • Healthfirst Life Improved Plan- NYU Risk
    • Healthfirst Medicaid
    • Healthfirst Medicaid- NYU Risk
    • Healthfirst Personal Wellness Plan
    • Healthfirst Personal Wellness Plan- NYU Risk
    • Healthfirst Platinum Leaf Exchange
    • Healthfirst Platinum Leaf Exchange- NYU Risk
    • Healthfirst Senior Health Partners
    • Healthfirst Senior Health Partners- NYU Risk
    • Healthfirst Silver Leaf Exchange
    • Healthfirst Silver Leaf Exchange- NYU Risk
  • Humana
    • Humana Medicare Advantage
  • Medicare
    • Medicare Part A
    • Medicare Part A and B
    • Medicare Part B
  • Railroad Medicare
    • Palmetto GBA Railroad Medicare
  • Sedgwick
    • WTC Health Program-North Shore
  • United Healthcare
    • United Health Care Options PPO (NYULMC Employees)
    • United Healthcare Choice (NYULMC Employees)
  • Veterans Admin. Referral
    • Veterans Admin. Referral
NYU Center For Musculoskeletal Care

333 East 38th Street, 4th Floor
New York, NY 10016

Ambulatory Care Services - Lupus Clinic

324 East 23rd Street
New York, NY 10010

Contact

Phone: 212-598-6321

Ambulatory Care Services - Osteoporosis Clinic

324 East 23rd Street
New York, NY 10010

Contact

Phone: 212-598-6321

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Research My Research

Isolated congenital heart block (CHB), detected in utero in a previously normal heart, is strongly associated with autoantibodies that recognize the intracellular soluble ribonucleoproteins 48kD SSB/La, 52kD SSA/Ro, and 60kD SSA/Ro. Neonatal disease is presumed to be due to the transplacental passage of these IgG autoantibodies into the fetal circulation from the mother who may have systemic lupus erythematosus, Sjogren syndrome, or be entirely asymptomatic. However, the role of these antibodies in the direct pathogenesis of cardiac injury is unknown. After characterizing numerous affected neonates and their mothers with respect to health status and antibody profile, we have focused on explaining two major clinical observations: 1) permanent disease does not occur in other fetal organs and the maternal heart is unaffected despite exposure to the identical circulating antibodies; and 2) not all mothers with these antibodies have offspring with disease implying involvement of as yet unknown factors. In addition to these considerations is the overriding question of how intracellular antigens become accessible targets of maternal autoantibodies. We demonstrated that a major antigenic target characterizing the autoimmune response in mothers whose children have manifestations of neonatal lupus is the 52kD Ro protein (52a), which contains an N-terminal zinc finger domain and central leucine zipper. We recently identified an alternative 52mRNA derived from splicing exon 4 inclusive of the leucine zipper, which encodes a smaller protein, 52b, with a predicted molecular weight of 45kD which is immunoprecipitated by over 80% of sera from CHB mothers. Expression of 52b is greatest between 14 and 16 wks of gestation, a time of cardiac ontogeny when maternal antibodies gain access to the fetal circulation just prior to the clinical detection of CHB. Additionally, protein interactions with 52a and 52b are being sought using human adult and fetal (14-24 wk) heart libraries in a two-hybrid system. Human fetal cardiocytes are being cultured to address issues of antigen localization and accessibility to antibody under different conditions. To further the study of neonatal lupus and congenital heart block, we established a national Research Registry for Neonatal Lupus which currently includes 352 affected families.

Publications

  • Autoimmune congenital heart block: complex and unusual situations

    Brito-Zeron, P; Izmirly, P M; Ramos-Casals, M; Buyon, J P; Khamashta, M A Brito-Zeron, P; Izmirly, P M; Ramos-Casals, M; Buyon, J P; Khamashta, M A
    Lupus. 2016 Feb . 25 (2): 116-128

  • Predictors of Pregnancy Outcomes in Patients With Lupus

    Buyon, Jill P; Kim, Mimi Y; Salmon, Jane E Buyon, Jill P; Kim, Mimi Y; Salmon, Jane E
    Annals of internal medicine. 2016 Jan 19. 164 (2): 131-131

  • Reduction in erythrocyte-bound complement activation products and titres of anti-C1q antibodies associate with clinical improvement in systemic lupus erythematosus

    Buyon, Jill; Furie, Richard; Putterman, Chaim; Ramsey-Goldman, Rosalind; Kalunian, Kenneth; Barken, Derren; Conklin, John; Dervieux, Thierry Buyon, Jill; Furie, Richard; Putterman, Chaim; Ramsey-Goldman, Rosalind; Kalunian, Kenneth; Barken, Derren; Conklin, John; Dervieux, Thierry
    Lupus science & medicine. 2016 Sep 30. 3 (1): e000165-e000165 e000165

Read All Publications (469)