Jill P. Buyon, MD

  • Specialty: Rheumatology
  • Language: English
  • Phone: 646-501-7400
Director
Lupus Center
Named
One of America’s Top Doctors by Castle Connolly for 10+ Years
Foremost Expert
On Autoimmune Diseases in Pregnancy

About Me

I chose a career in medicine because I loved the idea of every day being a challenge. Rather than being knowledgeable about a broad range of diseases, I sought to focus on just a few conditions and, in this way, build true expertise. These conditions include lupus, lupus-like conditions, pre-lupus, and Sjogren’s syndrome, each of which can affect women more than men and can strike during childbearing years.

My greatest area of expertise is the counseling and care of women who have lupus and are either pregnant or contemplating pregnancy. At NYU Langone, we are extraordinarily positioned to address complications that may arise during pregnancy, such as high blood pressure, kidney problems, lupus flares, and preterm birth. We work with a team of obstetricians who are experts in managing high-risk pregnancies.

It’s essential to remember that people who have the same disease, such as lupus, are all different. Treatment needs to be tailored to meet each person’s needs. I spend lots of time getting to know my patients so I can put treatment guidelines into the context of each person’s lifestyle.

Our Lupus Center participates in almost all major clinical trials for lupus treatment and our research laboratory is supported by grants from the National Institutes of Health. From a basic research perspective, we are currently trying to understand how certain antibodies in women with lupus and Sjogren’s syndrome can result in damage to the developing fetal heart.

Our ongoing studies are aimed at understanding why people who have lupus may be at a higher risk of developing atherosclerosis. We are also working on figuring out what triggers the development of lupus in the first place.

I am proud to have received a few major awards highlighting my extensive work in lupus. I have been given the Evelyn V. Hess, MD, MACP, MACR Award from the Lupus Foundation of America for achievements in lupus research, the Distinguished Clinical Investigator Award from the American College of Rheumatology, and the Halsted R. Holman Award for Excellence in Clinical Research at the LUPUS 2014 meeting.


Conditions and Treatments

rheumatism, lupus erythematosus, systemic lupus erythematosus (SLE), sicca syndrome

Credentials

Positions
  • Lady Va and Sir Deryck Maughan Professor of Rheumatology, Department of Medicine
  • Dir Division of Rheumatology
  • Dir Lupus Center
Board Certifications
  • American Board of Internal Medicine (Rheumatology), 1984
  • American Board of Internal Medicine - Internal Medicine, 1981
Education and Training
  • Fellowship, Hospital For Joint Diseases, Molecular Biology, 1986
  • Fellowship, NYU Medical Center, Rheumatology, 1983
  • Residency, Bronx Municipal Hospital Cntr, Internal Medicine, 1981
  • MD from Albert Einstein College of Med, 1978
Departments

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Locations and Appointments

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NYU Center For Musculoskeletal Care

333 East 38th Street, 4th Floor
New York, NY 10016

Ambulatory Care Services - Lupus Clinic

324 East 23rd Street
New York, NY 10010

Ambulatory Care Services - Osteoporosis Clinic

324 East 23rd Street
New York, NY 10010

Research My Research

Interests

immunology, maternal anti-SSA/Ro-SSB/La antibodies and pathogenesis of congenital heart block

Research Summary

Isolated congenital heart block (CHB), detected in utero in a previously normal heart, is strongly associated with autoantibodies that recognize the intracellular soluble ribonucleoproteins 48kD SSB/La, 52kD SSA/Ro, and 60kD SSA/Ro. Neonatal disease is presumed to be due to the transplacental passage of these IgG autoantibodies into the fetal circulation from the mother who may have systemic lupus erythematosus, Sjogren syndrome, or be entirely asymptomatic. However, the role of these antibodies in the direct pathogenesis of cardiac injury is unknown. After characterizing numerous affected neonates and their mothers with respect to health status and antibody profile, we have focused on explaining two major clinical observations: 1) permanent disease does not occur in other fetal organs and the maternal heart is unaffected despite exposure to the identical circulating antibodies; and 2) not all mothers with these antibodies have offspring with disease implying involvement of as yet unknown factors. In addition to these considerations is the overriding question of how intracellular antigens become accessible targets of maternal autoantibodies. We demonstrated that a major antigenic target characterizing the autoimmune response in mothers whose children have manifestations of neonatal lupus is the 52kD Ro protein (52a), which contains an N-terminal zinc finger domain and central leucine zipper. We recently identified an alternative 52mRNA derived from splicing exon 4 inclusive of the leucine zipper, which encodes a smaller protein, 52b, with a predicted molecular weight of 45kD which is immunoprecipitated by over 80% of sera from CHB mothers. Expression of 52b is greatest between 14 and 16 wks of gestation, a time of cardiac ontogeny when maternal antibodies gain access to the fetal circulation just prior to the clinical detection of CHB. Additionally, protein interactions with 52a and 52b are being sought using human adult and fetal (14-24 wk) heart libraries in a two-hybrid system. Human fetal cardiocytes are being cultured to address issues of antigen localization and accessibility to antibody under different conditions. To further the study of neonatal lupus and congenital heart block, we established a national Research Registry for Neonatal Lupus which currently includes 352 affected families.

Academic Contact

Lab Website

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • Progress in the pathogenesis and treatment of cardiac manifestations of neonatal lupus

    Izmirly, Peter; Saxena, Amit; Buyon, Jill P Izmirly, Peter; Saxena, Amit; Buyon, Jill P
    Current opinion in rheumatology. 2017 Sep . 29 (5): 467-472

  • Clinical and Pathologic Implications of Extending the Spectrum of Maternal Autoantibodies Reactive with Ribonucleoproteins Associated with Cutaneous and Now Cardiac Neonatal Lupus from SSA/Ro and SSB/La to U1RNP

    Izmirly, Peter M; Halushka, Marc K; Rosenberg, Avi Z; Whelton, Sean; Rais-Bahrami, Khodayar; Nath, Dilip S; Parton, Hilary; Clancy, Robert M; Rasmussen, Sara; Saxena, Amit; Buyon, Jill P Izmirly, Peter M; Halushka, Marc K; Rosenberg, Avi Z; Whelton, Sean; Rais-Bahrami, Khodayar; Nath, Dilip S; Parton, Hilary; Clancy, Robert M; Rasmussen, Sara; Saxena, Amit; Buyon, Jill P
    Autoimmunity reviews. 2017 Jul 12. 16 (9): 980-983

  • Cardiac Fibroblast Transcriptome Analyses Support a Role for Interferogenic, Profibrotic and Inflammatory Genes in Anti-SSA/Ro-Associated Congenital Heart Block

    Clancy, Robert M; Markham, Androo J; Jackson, Tanisha; Rasmussen, Sara E; Blumenberg, Miroslav; Buyon, Jill P Clancy, Robert M; Markham, Androo J; Jackson, Tanisha; Rasmussen, Sara E; Blumenberg, Miroslav; Buyon, Jill P
    American journal of physiology. Heart & circulatory physiology. 2017 Jun 16. ajpheart.00256.2017-ajpheart.00256.2017 ajpheart.00256.2017

Read All Publications (496)