Michael Schlame, MD

  • Specialties: Cardiac Anesthesiology, Anesthesiology
  • Language: English
  • Phone: 212-263-5072

Credentials

Positions
  • Associate Professor, Department of Anesthesiology, Perioperative Care, and Pain Medicine
  • Associate Professor, Department of Cell Biology
  • Director Cardiac Anesthesia
Board Certifications
  • American Board of Anesthesiology - Anesthesiology, 2006
Education and Training
  • Residency, NYU Medical Center, Anesthesiology, 2004
  • Residency, New York Presbyterian - Weill Cornell Medical Center, Anesthesiology, 2001
  • MD from Medical Academy Of Magdeburg, 1985

Locations and Appointments

View Insurance Plans Accepted
  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna POS
    • Aetna PPO/EPO
  • Affinity
    • Affinity
  • Agewell
    • Agewell
  • Cigna
    • Cigna EPO/POS
  • Emblem
    • Emblem Select Care Exchange
  • Empire Blue Cross Blue Shield
    • Empire Blue Cross Blue Shield EPO
    • Empire Blue Cross Blue Shield HMO
    • Empire Blue Cross Blue Shield HealthPlus
    • Empire Blue Cross Blue Shield HealthPlus Essential
    • Empire Blue Cross Blue Shield Indemnity
    • Empire Blue Cross Blue Shield MediBlue
    • Empire Blue Cross Blue Shield POS
    • Empire Blue Cross Blue Shield PPO
    • Empire Blue Cross Blue Shield Pathways, Enhanced
  • Fidelis
    • Fidelis Child Health
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    • Fidelis Family Health
    • Fidelis Medicaid
    • Fidelis Medicare
  • GHI
    • GHI CBP
  • HIP
    • HIP Access I
    • HIP Access II
    • HIP Child Health
    • HIP EPO/PPO
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    • HIP Family Health
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    • HIP Medicaid
    • HIP Medicare
    • HIP POS
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    • HealthSmart (WTC)
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    • Healthfirst
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  • Hotel Trades
    • Hotel Trades
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    • Humana Medicare
  • ICSNY
    • Independent Care System New York
  • Local 1199
    • Local 1199 PPO
  • MagnaCare
    • MagnaCare PPO
  • Medicaid
    • NY Medicaid
  • Medicare
    • Medicare
  • MetroPlus
    • MetroPlus Child Health
  • MultiPlan/PHCS
    • MultiPlan/PHCS PPO
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    • NYS Empire Plan
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    • Oscar
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    • Oxford Freedom
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    • Tricare
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    • UnitedHealthcare Community & State Plan
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    • Village Caremax
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    • WellCare Child Health
NYU Anesthesia Associates

560 1st Avenue
New York, NY 10016

Contact

Phone: 212-263-5072

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My Research

Barth syndrome is a hereditary cardiomyopathy that also affects skeletal muscles, growth, and neutrophils. The mutated gene (tafazzin) is homologous to a conserved family of phospholipid acyltransferases. Children with Barth syndrome are deficient in the mitochondrial phospholipid cardiolipin, suggesting that the primary defect of the disease may indeed be found in phospholipid metabolism and may specifically affect the phospholipids of mitochondria. We want to study the mechanism by which tafazzin mutation causes cardiomyopathy and skeletal muscle disease. First, we want to identify the enzymatic function of tafazzin. We will identify the intracellular localization of tafazzin, its impact on lipid composition, and its mechanism of action. Second, we want to examine the effect of tafazzin on structure and function of mitochondria. Since mitochondrial dysfunction is a plausible etiology of cardiomyopathy and skeletal muscle weakness, we will analyze mitochondrial ultrastructure and oxidative phosphorylation in cell lines with tafazzin deletion. Third, we want to explore a Drosophila model of Barth syndrome, which was created in our laboratory. We will study lipid metabolism, muscle physiology, morphology, and mitochondrial ultrastructure in fruit flies with tafazzin deletion. The Drosophila model will also be used for cardiac studies since flies contain a contractile fluid pumping organ that shares conserved features of cardiogenesis with all heart-forming creatures, including humans. The project will provide insight into the pathologic mechanism of a unique disease, which presents a novel pathway from lipid defect(s) to cardio-skeletal myopathy. Such information may be useful for the development of new therapeutic approaches to cardiomyopathy and skeletal muscle disease.

Publications

  • Cardiolipin as key lipid of mitochondria in health and disease. 2nd Edition, Florence, Italy, September 30-October 1, 2015

    Corcelli, Angela; Schlame, Michael Corcelli, Angela; Schlame, Michael
    Chemistry & physics of lipids. 2016 Apr 27. 198: 10-12

  • Biosynthesis, remodeling and turnover of mitochondrial cardiolipin

    Schlame, Michael; Greenberg, Miriam L Schlame, Michael; Greenberg, Miriam L
    Biochimica & biophysica acta. 2016 Aug 21. 1862 (1): 3-7

  • Loss of protein association causes cardiolipin degradation in Barth syndrome

    Xu, Yang; Phoon, Colin K L; Berno, Bob; D'Souza, Kenneth; Hoedt, Esthelle; Zhang, Guoan; Neubert, Thomas A; Epand, Richard M; Ren, Mindong; Schlame, Michael Xu, Yang; Phoon, Colin K L; Berno, Bob; D'Souza, Kenneth; Hoedt, Esthelle; Zhang, Guoan; Neubert, Thomas A; Epand, Richard M; Ren, Mindong; Schlame, Michael
    Nature chemical biology. 2016 Jun 27. 12 (8): 641-647

Read All Publications (89)