David Zagzag, MD, PHD

  • Specialties: Neuropathology, Anatomic Pathology
  • Languages: English, French
  • Phone: 212-263-8222

Credentials

Positions
  • Professor, Department of Pathology
  • Professor, Department of Neurosurgery
  • Chief Division of Neuropathology
  • Director Microvascular and Molecular Neuro-Oncology Laboratory
  • Dir Human Brain Tumor Bank
Board Certifications
  • American Board of Pathology (Neuropathology), 1993
  • American Board of Pathology - Anatomic Pathology, 1993
Education and Training
  • Fellowship, NYU Medical Center, Neuropathology, 1992
  • Residency, NYU Medical Center, Surgical Pathology, 1990
  • PHD from McGill University, 1988
Departments

Locations and Appointments

68 Insurance Plans Accepted
  • Aetna HMO
  • Aetna Indemnity
  • Aetna Medicare
  • Aetna POS
  • Aetna PPO/EPO
  • Affinity
  • Affinity Exchange- Essential
  • Cigna EPO/POS
  • Cigna PPO
  • ElderPlan
  • Empire Blue Cross Blue Shield EPO
  • Empire Blue Cross Blue Shield HMO
  • Empire Blue Cross Blue Shield Indemnity
  • Empire Blue Cross Blue Shield MediBlue
  • Empire Blue Cross Blue Shield POS
  • Empire Blue Cross Blue Shield PPO
  • Empire Blue Cross Blue Shield Pathways, Enhanced
  • Fidelis Child Health
  • Fidelis Exchange
  • Fidelis Family Health
  • Fidelis Medicaid
  • Fidelis Medicare
  • GHI CBP
  • HIP Access I
  • HIP Access II
  • HIP Child Health
  • HIP EPO/PPO
  • HIP Family Health
  • HIP HMO
  • HIP Medicaid
  • HIP Medicare
  • HIP POS
  • HealthPlus Child Health (Amerigroup)
  • HealthPlus Family Health (Amerigroup)
  • HealthPlus Medicaid (Amerigroup)
  • HealthRepublic
  • HealthSmart (WTC)
  • Hotel Trades
  • Humana Medicare
  • Local 1199 PPO
  • MagnaCare PPO
  • Medicare
  • MetroPlus Child Health
  • MetroPlus Exchange Plans
  • MetroPlus Family Health
  • MetroPlus Medicaid
  • MultiPlan/PHCS PPO
  • NY Medicaid
  • NYS Empire Plan
  • Oscar
  • Oxford Exchange
  • Oxford Freedom
  • Oxford Liberty
  • Oxford Medicare
  • Touchstone Medicare
  • Tricare
  • United Exchange- Compass
  • UnitedHealthcare Community & State Plan
  • UnitedHealthcare EPO
  • UnitedHealthcare HMO
  • UnitedHealthcare Medicare
  • UnitedHealthcare POS
  • UnitedHealthcare PPO
  • UnitedHealthcare Top Tier
  • WellCare Child Health
  • WellCare Family Health
  • WellCare Medicaid
  • WellCare Medicare
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.
NYU Pathology Associates

160 East 34th Street, 10th Floor
New York, NY 10016

Contact

Phone: 212-263-8222

Welcome back!

As a returning patient for this doctor, please schedule an appointment using your MyChart at NYU Langone account.

Learn more about MyChart at NYU Langone.

My Research

Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive vascular network is established from multipotential mesenchymal progenitors, and angiogenesis, in which preexisting vessels (both in embryo and adult) send out capillary sprouts to produce new vessels. Angiogenesis and vasculogenesis as previously defined, are crucial process in both neural embryogenesis and neoplasia. Several angiogenic and vasculogenic factors and extracellular matrix (ECM) proteins have been implicated in the development and maturation of the central nervous system (CNS) and in the biology of brain tumors. The interaction between ECM components and these factors plays an important role in every step of the angiogenic and vasculogenic cascades. Our interest is in elucidating the expression patterns, trigger mechanisms, pathophysiological and molecular mechanisms that are related to the expression of both vasculogenic and angiogenic factors and ECM proteins.

Recently, we have focused our investigations on an ECM molecule, tenascin (TN). TN is a large complex protein of the ECM which is expressed in developing brain, cartilage and mesenchyme and is re-expressed in tumors, wound healing and inflammation. It is believed to be important for several cellular processes including cell adhesion, migration, and proliferation. In contrast to the low levels of TN found in normal adult brain, enhanced expression occurs in CNS embryogenesis and human astrocytomas. In situ hybridization of astrocytomas detects strong staining for TN mRNA in vascular cells, especially in hyperplastic vessels, including those at the invasive edge of the tumors, but not in normal brain vessels.

Tie-1 and Tie-2, two receptor tyrosine kinases, and their ligands angiopoetins have recently been described and are critical for vasculogenesis. We are currently investigating how these might be implicated in brain neoplasms.

Publications

  • ERG is a novel and reliable marker for endothelial cells in central nervous system tumors

    Haber, Matthew A; Iranmahboob, Amir; Thomas, Cheddhi; Liu, Mengling; Najjar, Amanda; Zagzag, David
    Clinical neuropathology. 2015 Apr. 110-110

  • Prognostic marker analysis in pediatric intracranial ependymomas

    McLendon, Roger E; Lipp, Eric; Satterfield, Diane; Ehinger, Melissa; Austin, Alan; Fleming, Debra; Perkinson, Kathryn; Lefaivre, Michaela; Zagzag, David; Wiener, Benjamin; Gururangan, Sri; Fuchs, Herbert; Friedman, Henry S; Herndon, James E 2nd; Healy, Patrick
    Journal of neuro-oncology. 2015 Apr. 122 (2): 255-261

  • Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

    Pajtler, Kristian W; Witt, Hendrik; Sill, Martin; Jones, David T W; Hovestadt, Volker; Kratochwil, Fabian; Wani, Khalida; Tatevossian, Ruth; Punchihewa, Chandanamali; Johann, Pascal; Reimand, Juri; Warnatz, Hans-Jorg; Ryzhova, Marina; Mack, Steve; Ramaswamy, Vijay; Capper, David; Schweizer, Leonille; Sieber, Laura; Wittmann, Andrea; Huang, Zhiqin; van Sluis, Peter; Volckmann, Richard; Koster, Jan; Versteeg, Rogier; Fults, Daniel; Toledano, Helen; Avigad, Smadar; Hoffman, Lindsey M; Donson, Andrew M; Foreman, Nicholas; Hewer, Ekkehard; Zitterbart, Karel; Gilbert, Mark; Armstrong, Terri S; Gupta, Nalin; Allen, Jeffrey C; Karajannis, Matthias A; Zagzag, David; Hasselblatt, Martin; Kulozik, Andreas E; Witt, Olaf; Collins, V Peter; von Hoff, Katja; Rutkowski, Stefan; Pietsch, Torsten; Bader, Gary; Yaspo, Marie-Laure; von Deimling, Andreas; Lichter, Peter; Taylor, Michael D; Gilbertson, Richard; Ellison, David W; Aldape, Kenneth; Korshunov, Andrey; Kool, Marcel; Pfister, Stefan M
    Cancer cell. 2015 May. 27 (5): 728-743

Read All Publications (265)