David Zagzag, MD, PHD

  • Specialties: Neuropathology, Anatomic Pathology
  • Languages: English, French
  • Phone: 212-263-8222



  • Professor, Department of Pathology
  • Professor, Department of Neurosurgery
  • Chief Division of Neuropathology
  • Dir Microvascular and Molecular Neuro-Onc Lab
  • Dir Human Brain Tumor Bank

Board Certifications

  • American Board of Pathology (Neuropathology)
  • American Board of Pathology - Anatomic Pathology

Education and Training

  • 1992
  • Fellowship, NYU Medical Center, Neuropathology
  • 1990
  • Residency, NYU Medical Center, Surgical Pathology
  • 1988
  • PHD from Mcgill University
  • Other Credentials
  • from


Locations and Appointments

69 Insurance Plans Accepted
  • Aetna HMO
  • Aetna Indemnity
  • Aetna Medicare
  • Aetna POS
  • Aetna PPO/EPO
  • Affinity
  • Affinity Exchange- Essential
  • Cigna EPO/POS
  • Cigna PPO
  • ElderPlan
  • Empire Blue Cross Blue Shield EPO
  • Empire Blue Cross Blue Shield HMO
  • Empire Blue Cross Blue Shield Healthy NY
  • Empire Blue Cross Blue Shield Indemnity
  • Empire Blue Cross Blue Shield MediBlue
  • Empire Blue Cross Blue Shield POS
  • Empire Blue Cross Blue Shield PPO
  • Empire Blue Cross Blue Shield Pathways, Enhanced
  • Fidelis Child Health
  • Fidelis Exchange
  • Fidelis Family Health
  • Fidelis Medicaid
  • Fidelis Medicare
  • HIP Access I
  • HIP Access II
  • HIP Child Health
  • HIP Family Health
  • HIP Medicaid
  • HIP Medicare
  • HealthPlus Child Health (Amerigroup)
  • HealthPlus Family Health (Amerigroup)
  • HealthPlus Medicaid (Amerigroup)
  • HealthRepublic
  • HealthSmart (WTC)
  • Hotel Trades
  • Humana Medicare
  • Local 1199 PPO
  • MagnaCare PPO
  • Medicare
  • MetroPlus Child Health
  • MetroPlus Exchange Plans
  • MetroPlus Family Health
  • MetroPlus Medicaid
  • MultiPlan/PHCS PPO
  • NY Medicaid
  • NYS Empire Plan
  • Oscar
  • Oxford Exchange
  • Oxford Freedom
  • Oxford Liberty
  • Oxford Medicare
  • Touchstone Medicare
  • Tricare
  • United Exchange- Compass
  • UnitedHealthcare Community & State Plan
  • UnitedHealthcare EPO
  • UnitedHealthcare HMO
  • UnitedHealthcare Medicare
  • UnitedHealthcare POS
  • UnitedHealthcare PPO
  • UnitedHealthcare Top Tier
  • WellCare Child Health
  • WellCare Family Health
  • WellCare Medicaid
  • WellCare Medicare
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.

NYU Pathology Associates
160 East 34th Street, 10th Floor
New York, NY 10016


Phone: 212-263-8222

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My Research

Mechanisms of Cerebral Vasculogenesis and Angiogenesis

Blood vessels are constructed by two processes: vasculogenesis, whereby a primitive vascular network is established from multipotential mesenchymal progenitors, and angiogenesis, in which preexisting vessels (both in embryo and adult) send out capillary sprouts to produce new vessels. Angiogenesis and vasculogenesis as previously defined, are crucial process in both neural embryogenesis and neoplasia. Several angiogenic and vasculogenic factors and extracellular matrix (ECM) proteins have been implicated in the development and maturation of the central nervous system (CNS) and in the biology of brain tumors. The interaction between ECM components and these factors plays an important role in every step of the angiogenic and vasculogenic cascades. Our interest is in elucidating the expression patterns, trigger mechanisms, pathophysiological and molecular mechanisms that are related to the expression of both vasculogenic and angiogenic factors and ECM proteins.

Recently, we have focused our investigations on an ECM molecule, tenascin (TN). TN is a large complex protein of the ECM which is expressed in developing brain, cartilage and mesenchyme and is re-expressed in tumors, wound healing and inflammation. It is believed to be important for several cellular processes including cell adhesion, migration, and proliferation. In contrast to the low levels of TN found in normal adult brain, enhanced expression occurs in CNS embryogenesis and human astrocytomas. In situ hybridization of astrocytomas detects strong staining for TN mRNA in vascular cells, especially in hyperplastic vessels, including those at the invasive edge of the tumors, but not in normal brain vessels.

Tie-1 and Tie-2, two receptor tyrosine kinases, and their ligands angiopoetins have recently been described and are critical for vasculogenesis. We are currently investigating how these might be implicated in brain neoplasms.


  • Medulloblastoma subgroups remain stable across primary and metastatic compartments

    Wang, Xin; Dubuc, Adrian M; Ramaswamy, Vijay; Mack, Stephen; Gendoo, Deena M A; Remke, Marc; Wu, Xiaochong; Garzia, Livia; Luu, Betty; Cavalli, Florence; Peacock, John; Lopez, Borja; Skowron, Patryk; Zagzag, David; Lyden, David; Hoffman, Caitlin; Cho, Yoon-Jae; Eberhart, Charles; MacDonald, Tobey; Li, Xiao-Nan; Van Meter, Timothy; Northcott, Paul A; Haibe-Kains, Benjamin; Hawkins, Cynthia; Rutka, James T; Bouffet, Eric; Pfister, Stefan M; Korshunov, Andrey; Taylor, Michael D 2015 Mar; 449-457, Acta neuropathologica — id: 1509642, year: 2015, page: 449, stat: Journal Article
  • Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature

    Bassani, Luigi; Graffeo, Christopher S; Behrooz, Navid; Tyagi, Vineet; Wilson, Taylor; Penaranda, Saul; Zagzag, David; Rifkin, Daniel B; Barcellos-Hoff, Mary Helen; Fatterpekar, Girish; Placantonakis, Dimitris 2014; 8-8, Surgical neurology international — id: 820792, year: 2014, page: 8, stat: Journal Article
  • Selective Lentiviral Gene Delivery to CD133-Expressing Human Glioblastoma Stem Cells

    Bayin, N Sumru; Modrek, Aram S; Dietrich, August; Lebowitz, Jonathan; Abel, Tobias; Song, Hae-Ri; Schober, Markus; Zagzag, David; Buchholz, Christian J; Chao, Moses V; Placantonakis, Dimitris G 2014; e116114-e116114, PLoS one — id: 1419672, year: 2014, page: e116114, stat: Journal Article
Read All Publications (262)