Bo Shopsin at [NYU Langone Medical Center]

Bo Shopsin, MD, PhD

  • Specialty: Infectious Diseases & Immunology
  • Language: English
  • Phone: 212-375-2940

Credentials

Positions
  • Assistant Professor, Department of Medicine
  • Assistant Professor, Department of Microbiology
Board Certifications
  • American Board of Internal Medicine (Infectious Disease), 2006
Education and Training
  • Fellowship, New York University, Infectious Diseases, 2006
  • Residency, New York University, Internal Medicine, 2004
  • MD from New York University, 2001
  • PhD from New York University, 2000
Departments

Locations and Appointments

530 1st Avenue, Suite 7J
New York, NY 10016

Contact

Phone: 212-375-2940

New Bellevue Hospital

462 First Avenue, 16th Floor, 16S5
New York, NY 10016

Contact

Phone: 212-263-6402

Welcome back!

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My Research

Our lab is focused on understanding the adaptive changes in S. aureus that take place during infection. An integrated approach is used that incorporates new technologies to detect low abundance variants in pooled bacterial populations, traditional bacterial and evolutionary genetics, and molecular population genetic analysis. A special focus of these studies is on the identification of within-host variation in the agr locus, a global regulator of virulence in S. aureus. agr mutants are attenuated for virulence in animal models of infection, and the majority of clinical isolates have a functional agr locus. However, agr-defective strains are frequently recovered from patients with a variety of hospital-acquired infections, suggesting that the occurrence of these strains may be favored under certain in vivo conditions. This work is motivated by practical questions in infectious diseases (such as the best use of antimicrobials that target agr and virulence), as well as more basic yet closely intertwined questions, such as how to explain the alterations that are responsible for adaptive changes atdifferent stages of S. aureus infections.

Learn more about my research

Publications

  • An rpsL-based allelic exchange vector for Staphylococcus aureus

    Chen, John; Ram, Geeta; Yoong, Pauline; Penades, Jose R; Shopsin, Bo; Novick, Richard P
    Plasmid. 2015 Feb 7. 79: 8-14

  • The Cutaneous Microbiome in Outpatients Presenting With Acute Skin Abscesses

    Horton, James M; Gao, Zhan; Sullivan, D Matthew; Shopsin, Bo; Perez-Perez, Guillermo I; Blaser, Martin J
    Journal of infectious diseases. 2015 Jan 12. 211 (12): 1895-1904

  • Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection

    Wilde, Aimee D; Snyder, Daniel J; Putnam, Nicole E; Valentino, Michael D; Hammer, Neal D; Lonergan, Zachery R; Hinger, Scott A; Aysanoa, Esar E; Blanchard, Catlyn; Dunman, Paul M; Wasserman, Gregory A; Chen, John; Shopsin, Bo; Gilmore, Michael S; Skaar, Eric P; Cassat, James E
    PLoS pathogens. 2015 Dec 18. 11 (12): e1005341-e1005341 e1005341

Read All Publications (32)