Bo Shopsin at [NYU Langone Health]

Bo Shopsin, MD, PhD

  • Specialty: Infectious Diseases & Immunology
  • Language: English

Credentials

Positions
  • Assistant Professor, Department of Medicine
  • Assistant Professor, Department of Microbiology
  • Director, Molecular Epidemiology
Education and Training
  • Fellowship, New York University, Infectious Diseases, 2006
  • Residency, New York University, Internal Medicine, 2004
  • MD from New York University, 2001
  • PhD from New York University, 2000
Departments

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Research My Research

Interests

genomics, immunology, microbiology

Research Summary

Our lab is focused on understanding the adaptive changes in S. aureus that take place during infection. An integrated approach is used that incorporates new technologies to detect low abundance variants in pooled bacterial populations, traditional bacterial and evolutionary genetics, and molecular population genetic analysis. A special focus of these studies is on the identification of within-host variation in the agr locus, a global regulator of virulence in S. aureus. agr mutants are attenuated for virulence in animal models of infection, and the majority of clinical isolates have a functional agr locus. However, agr-defective strains are frequently recovered from patients with a variety of hospital-acquired infections, suggesting that the occurrence of these strains may be favored under certain in vivo conditions. This work is motivated by practical questions in infectious diseases (such as the best use of antimicrobials that target agr and virulence), as well as more basic yet closely intertwined questions, such as how to explain the alterations that are responsible for adaptive changes atdifferent stages of S. aureus infections.

Learn more about my research

Academic Contact

Lab Website

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way

    Shopsin, Bo; Kaveri, Srini V; Bayry, Jagadeesh Shopsin, Bo; Kaveri, Srini V; Bayry, Jagadeesh
    Cell host & microbe. 2016 Nov 09. 20 (5): 555-557

  • Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection

    Wilde, Aimee D; Snyder, Daniel J; Putnam, Nicole E; Valentino, Michael D; Hammer, Neal D; Lonergan, Zachery R; Hinger, Scott A; Aysanoa, Esar E; Blanchard, Catlyn; Dunman, Paul M; Wasserman, Gregory A; Chen, John; Shopsin, Bo; Gilmore, Michael S; Skaar, Eric P; Cassat, James E Wilde, Aimee D; Snyder, Daniel J; Putnam, Nicole E; Valentino, Michael D; Hammer, Neal D; Lonergan, Zachery R; Hinger, Scott A; Aysanoa, Esar E; Blanchard, Catlyn; Dunman, Paul M; Wasserman, Gregory A; Chen, John; Shopsin, Bo; Gilmore, Michael S; Skaar, Eric P; Cassat, James E
    PLoS pathogens. 2015 Dec. 11 (12): e1005341-e1005341 e1005341

  • Cytotoxic Virulence Predicts Mortality in Nosocomial Pneumonia Due to Methicillin-Resistant Staphylococcus aureus

    Rose, Hannah R; Holzman, Robert S; Altman, Deena R; Smyth, Davida S; Wasserman, Gregory A; Kafer, Jared M; Wible, Michelle; Mendes, Rodrigo E; Torres, Victor J; Shopsin, Bo Rose, Hannah R; Holzman, Robert S; Altman, Deena R; Smyth, Davida S; Wasserman, Gregory A; Kafer, Jared M; Wible, Michelle; Mendes, Rodrigo E; Torres, Victor J; Shopsin, Bo
    Journal of infectious diseases. 2015 Jun 15. 211 (12): 1862-1874

Read All Publications (33)