About Me
Conditions and Treatments
Conditions
- ventricular arrhythmia
- atrial fibrillation
- atrial flutter
- Brugada syndrome
- dilated cardiomyopathy
- heart muscle disease
- hypertrophic cardiomyopathy
- long QT syndrome
- myocardial disease
- rapid heartbeat
- slow heartbeat
- ventricular arrhythmia
- ventricular fibrillation
- ventricular tachycardia
- claudication
- arteriosclerosis
- heart attack
- occlusive vascular disease
- cerebrovascular disorder
- inflammation of the membrane surrounding the heart
- metabolic syndrome
- heart disease
- fainting
- angina
- high blood pressure disorder
- mitral regurgitation
- ischemic cardiomyopathy
- atherosclerosis
- myocarditis
- high cholesterol level
- chest pain
- renal artery stenosis
- aortic valve disease
- congestive heart failure
- peripheral vascular disease
- aortic valve insufficiency
- mitral valve prolapse
- cardiac disease in pregnancy
- carotid artery disease
- obesity
- endothelial dysfunction
- coronary heart disease
- rheumatic heart disease
- heart murmur
- lipid disorder
- aortic valve stenosis
- chronic venous insufficiency
- renal vascular disorder
- arterial occlusive disease
- mitral valve stenosis
- lipid metabolism
- carotid stenosis
- heart throbbing
- acute coronary syndrome
- inflammation of the heart valve
- sarcoidosis
- heart tumor
- abnormal heart rhythms
Learn more about conditions we treat at NYU Langone:
Atrial Fibrillation & Atrial Flutter in Adults, Cardiomyopathy & Heart Failure in Adults, Hypertrophic Cardiomyopathy, Stroke in Adults, Hypertension in Adults, Lipid Disorders in Adults, Renal Artery Stenosis in Adults, Aortic Valve Disease in Adults, Lower Extremity Arterial Disease in Adults, Mitral Valve Disease in Adults, Aortoiliac Occlusive Disease in Adults, Obesity in Adults, Coronary Artery Disease in Adults, Carotid Artery Disease in Adults, Chronic Venous Insufficiency in Adults, Sarcoidosis in AdultsCredentials
Positions
- William Goldring Professor of Medicine, Department of Medicine
- Professor, Department of Neuroscience and Physiology
- Professor, Department of Biochemistry and Molecular Pharmacology
- Vice Chair for Research, Department of Medicine
- Director, Leon H. Charney Division of Cardiology
Board Certifications
- American Board of Internal Medicine (Cardiovascular Disease), 1989
- American Board of Internal Medicine - Internal Medicine, 1986
Education and Training
- Fellowship, Albert Einstein College Hospital, Molecular Cardiology, 1990
- Fellowship, Columbia-Presbyterian Medical Ctr., Cardiology, 1988
- Residency, Massachusetts General Hospital, Medicine, 1986
- Residency, Massachusetts General Hospital, Medicine, 1984
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Interests
cardiovascular biology, cardiovascular development, cardiovascular genetics, cardiac electrophysiology and arrhythmias, immunology, metabolism
Research Summary
My laboratory focuses on several facets of cardiovascular biology and disease. First, we are interested in the formation and function of the heart's specialized cardiac conduction system (CCS). This complex network comprises pacemaking cells that establish the normal rhythmicity of the heart, as well as rapidly conducting His-Purkinje cells that facilitate highly synchronized excitation of the working myocardium.
Our studies of the conduction system utilize genetically engineered mouse models that specifically visualize various components of the network. Gene profiling of microdissected CCS tissue is then employed to identify the molecular signature of these specialized cells. A complementary approach for gene discovery using murine embryonic stem cells is being developed, whereby such pluripotent cells can be differentiated into specific components of the CCS under defined cultured conditions.
A second area of investigation includes studies of arrhythmia mechanisms, focusing especially on the dysregulation of gap junction channels and the associated abnormalities in impulse propagation. These studies include a multiple of strategies that range from molecular and biochemical through genetically engineered murine models with site-specific mutations in connexin genes, which encode the gap junction channel proteins. Our laboratory was the first to demonstrate the essential role of gap junction channels in cardiac rhythmicity, using conditional knockout approaches. Current studies are focused on defining the role of post-translational regulation of connexins during normal gap junction formation and in response to pathologic stimuli that lead to abnormal gap junction remodeling.
Research Interests Timeline
Publications
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Cappola, Anne R; Desai, Akshay S; Medici, Marco; Cooper, Lawton S; Egan, Debra; Sopko, George; Fishman, Glenn I; Goldman, Steven; Cooper, David S; Mora, Samia; Kudenchuk, Peter J; Hollenberg, Anthony N; McDonald, Cheryl L; Ladenson, Paul W
Thyroid. 2019 Jun ; 29(6):760-777
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Gando, Ivan; Williams, Nori; Fishman, Glenn I; Sampson, Barbara A; Tang, Yingying; Coetzee, William A
Forensic science international. 2019 May 29; 301:289-298
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Cappola, Anne R; Desai, Akshay S; Medici, Marco; Cooper, Lawton S; Egan, Debra; Sopko, George; Fishman, Glenn I; Goldman, Steven; Cooper, David S; Mora, Samia; Kudenchuk, Peter J; Hollenberg, Anthony N; McDonald, Cheryl L; Ladenson, Paul W
Circulation. 2019 May 13;