Glenn I. Fishman

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About Me

Conditions and Treatments

ventricular arrhythmia, atrial fibrillation, atrial flutter, Brugada syndrome, dilated cardiomyopathy, heart muscle disease, hypertrophic cardiomyopathy, long QT syndrome, myocardial disease, rapid heartbeat, slow heartbeat, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia, angina, heart murmur, inflammation of the membrane surrounding the heart, arterial occlusive disease, abnormal heart rhythms, chronic venous insufficiency, aortic valve insufficiency, lipid metabolism, renal vascular disorder, heart throbbing, occlusive vascular disease, heart disease, heart failure, ischemic cardiomyopathy, claudication, carotid artery disease, rheumatic heart disease, myocarditis, lipid disorder, high cholesterol level, mitral valve prolapse, coronary heart disease, mitral valve stenosis, renal artery stenosis, cerebrovascular disorder, congestive heart failure, acute coronary syndrome, peripheral vascular disease, sarcoidosis, aortic valve stenosis, heart tumor, mitral regurgitation, arteriosclerosis, aortic valve disease, heart attack, cardiac disease in pregnancy, chest pain, carotid stenosis, metabolic syndrome, obesity, fainting, endothelial dysfunction, high blood pressure disorder, inflammation of the heart valve, atherosclerosis
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  • William Goldring Professor of Medicine, Department of Medicine
  • Professor, Department of Neuroscience and Physiology
  • Professor, Department of Biochemistry and Molecular Pharmacology
  • Vice Chair for Research, Department of Medicine
  • Director, Leon H. Charney Division of Cardiology
Board Certifications
  • American Board of Internal Medicine (Cardiovascular Disease), 1989
  • American Board of Internal Medicine - Internal Medicine, 1986
Education and Training
  • Fellowship, Albert Einstein College Hospital, Molecular Cardiology, 1990
  • Fellowship, Columbia-Presbyterian Medical Ctr., Cardiology, 1988
  • Residency, Massachusetts General Hospital, Medicine, 1986
  • Residency, Massachusetts General Hospital, Medicine, 1984

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NYU Cardiology Associates

530 1st Avenue, Skirball 9U
New York, NY 10016

Research My Research


cardiovascular biology, cardiovascular development, cardiovascular genetics, cardiac electrophysiology and arrhythmias, immunology, metabolism

Research Summary

My laboratory focuses on several facets of cardiovascular biology and disease. First, we are interested in the formation and function of the heart's specialized cardiac conduction system (CCS). This complex network comprises pacemaking cells that establish the normal rhythmicity of the heart, as well as rapidly conducting His-Purkinje cells that facilitate highly synchronized excitation of the working myocardium.

Our studies of the conduction system utilize genetically engineered mouse models that specifically visualize various components of the network. Gene profiling of microdissected CCS tissue is then employed to identify the molecular signature of these specialized cells. A complementary approach for gene discovery using murine embryonic stem cells is being developed, whereby such pluripotent cells can be differentiated into specific components of the CCS under defined cultured conditions.

A second area of investigation includes studies of arrhythmia mechanisms, focusing especially on the dysregulation of gap junction channels and the associated abnormalities in impulse propagation. These studies include a multiple of strategies that range from molecular and biochemical through genetically engineered murine models with site-specific mutations in connexin genes, which encode the gap junction channel proteins. Our laboratory was the first to demonstrate the essential role of gap junction channels in cardiac rhythmicity, using conditional knockout approaches. Current studies are focused on defining the role of post-translational regulation of connexins during normal gap junction formation and in response to pathologic stimuli that lead to abnormal gap junction remodeling.

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication


Read All Publications (117)

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