Allan E. Rubenstein, MD

  • Specialties: Neuro-Oncology, Neurology
  • Language: English
  • Phone: 212-263-9695

About Me

As a specialist in genetic disorders of the nervous system at NYU Langone, I treat adults and children who have neurofibromatosis type 1 and type 2, and related disorders. Neurofibromatosis is a condition that causes tumors to form in the brain and spinal cord. In addition, I see patients who are experiencing a variety of neurological issues, particularly peripheral nerve and autonomic problems.

I co-founded the Children’s Tumor Foundation and served as its director of medical affairs for 25 years. During that time, I developed and led the foundation’s medical and research programs. My work at the foundation helped to advance the understanding of neurofibromatosis in the medical community and catalyze neurofibromatosis research efforts.

As part of NYU Langone’s Comprehensive Neurofibromatosis Center, I coordinate and manage a care team of a variety of specialists who have extensive expertise in neurofibromatosis and related disorders. Our center is one of the largest and most sophisticated centers of its kind.

We are involved in a number of clinical trials testing treatments for the tumors that develop in neurofibromatosis type 1 or type 2. I also work on nonsurgical approaches to treating people with dermal neurofibromas that develop in neurofibromatosis type 1, a special interest of mine for many years.

For my work in neurofibromatosis clinical care and research, I have been honored with the Friedrich von Recklinghausen Award from the Children’s Tumor Foundation and recognized in the Marquis’ “Who’s Who in the East” and “Who’s Who in Science and Engineering.”

I have also provided counsel to numerous research and government agencies, including the National Institute of Neurological Disorders and Stroke, the National Cancer Institute, the U.S. Food and Drug Administration’s Orphan Products Grant Program, and the Department of Defense’s Neurofibromatosis Research Program. I am a reviewer for several scientific publications and have authored three books on neurofibromatosis.


Conditions and Treatments

neurofibromatosis

Credentials

Positions
  • Clinical Professor, Department of Neurology
  • Clinical Professor, Department of Pediatrics
Board Certifications
  • American Board of Psychiatry & Neurology - Neurology, 1976
Education and Training
  • Residency, Columbia-Presbyterian Medical Center, Neurology, 1974
  • MD from Tufts University, 1970
Departments

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Stephen D. Hassenfeld Childrens Center for Cancer & Blood Disorders

160 East 32nd Street, 3rd Floor
New York, NY 10016

Research Academic Contact

Phone

212-263-9695

Publications

  • A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

    Cha, Jieun R C; St Louis, Kyle J H; Tradewell, Miranda L; Gentil, Benoit J; Minotti, Sandra; Jaffer, Zahara M; Chen, Ruihong; Rubenstein, Allan E; Durham, Heather D Cha, Jieun R C; St Louis, Kyle J H; Tradewell, Miranda L; Gentil, Benoit J; Minotti, Sandra; Jaffer, Zahara M; Chen, Ruihong; Rubenstein, Allan E; Durham, Heather D
    Cell stress chaperones. 2014 May. 19 (3): 421-435

  • Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2

    Tanaka, Karo; Eskin, Ascia; Chareyre, Fabrice; Jessen, Walter J; Manent, Jan; Niwa-Kawakita, Michiko; Chen, Ruihong; White, Cory H; Vitte, Jeremie; Jaffer, Zahara M; Nelson, Stanley F; Rubenstein, Allan E; Giovannini, Marco Tanaka, Karo; Eskin, Ascia; Chareyre, Fabrice; Jessen, Walter J; Manent, Jan; Niwa-Kawakita, Michiko; Chen, Ruihong; White, Cory H; Vitte, Jeremie; Jaffer, Zahara M; Nelson, Stanley F; Rubenstein, Allan E; Giovannini, Marco
    Clinical cancer research. 2013 Jul 15. 19 (14): 3856-3870

  • The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme

    Zhu, Haihao; Woolfenden, Steve; Bronson, Roderick T; Jaffer, Zahara M; Barluenga, Sofia; Winssinger, Nicolas; Rubenstein, Allan E; Chen, Ruihong; Charest, Al Zhu, Haihao; Woolfenden, Steve; Bronson, Roderick T; Jaffer, Zahara M; Barluenga, Sofia; Winssinger, Nicolas; Rubenstein, Allan E; Chen, Ruihong; Charest, Al
    Molecular cancer therapeutics. 2010 Sep. 9 (9): 2618-2626

Read All Publications (97)