Jeffrey Allen at [NYU Langone Health]

Jeffrey C. Allen, MD

  • Specialties: Pediatric Neurology, Neuro-Oncology, Pediatric Neuro-Oncology
  • Language: English
  • Phone: 212-263-9907
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About Me

As a pediatric neurologist and a neuro-oncologist at NYU Langone, I aim to improve the care of children and young adults who have primary central nervous system tumors, peripheral nerve tumors, and neurofibromatosis types 1 and 2—genetic conditions that can result in noncancerous tumors.

Through clinical and translational research tools and methods, I aim to better understand the natural history of central nervous system tumors with the intention of refining treatment to make it safer and more effective.

In 2008, I helped organize the team of physicians at NYU Langone that established the first Comprehensive Neurofibromatosis Center. We currently offer care and clinical trials for children and adults with neurofibromatosis types 1 and 2 and schwannomatosis.

In 2011, I was the principal investigator for a successful application to become a member of the Neurofibromatosis Clinical Trials Consortium, which is funded by the United States Department of Defense and includes 12 institutions within the United States. This affiliation gives our patients with neurofibromatosis access to advanced and innovative clinical trials.


Conditions and Treatments

brain tumor, spinal cord tumor, neurofibromatosis, peripheral nervous system tumor , meningioma, skull base tumor

Credentials

Positions
  • Professor, Department of Pediatrics
  • Professor, Department of Neurology
Board Certifications
  • American Board of Psychiatry & Neurology - w/Spec Qual's In Child Neurolo, 1977
Education and Training
  • Residency, Montreal Children's Hospital, Pediatrics, 1976
  • MD from Harvard Medical School, 1969
Departments

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Stephen D. Hassenfeld Childrens Center for Cancer & Blood Disorders

160 East 32nd Street, 3rd Floor
New York, NY 10016

Research My Research

Interests

clinical trials, pediatric neuro-oncology, neurofibromatosis, brain tumor, clinical and translational research in adults and children

Research Summary

A Brain Tumor Research Center at NYU School of Medicine was established in 1992 with an award from the National Institute of Neurological Disorders and Stroke to support a tumor bank, a patient database, and five research projects concentrating on: 1) tumor suppressor genes in genetically high risk pediatric brain tumor populations, 2) interaction of recessive and dominant oncogenes, 3) growth factors, 4) cell adhesion molecules, and 5) cellular immunology. The tumor bank has accrued over 3000 frozen/formalin fixed human brain, spinal and peripheral nerve tumor specimens and the patient and neurofibromatosis database tracks over patients. This unique resource facilitates many institutional and collaborative research projects and is funded by grants from the Making Headway Foundation. The Brain Tumor Research Center also facilitates clinical research neuro-oncology protocols, both institutional and cooperative group trials, and actively engages in pharmaceutical collaborations. The NYU Comprehensive Neurofibromatosis Center was initiated in 2008 and is rapidly evolving with acquisition of new staff members. We received a coveted award to become a member of the NF Clinical Trials Consortium in 2011 which offers our patients with NF1 and NF2 access to advanced clinical trials.

 

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Clinical Trials and Research Studies

  • NF PROTOCOL 108: A Phase II Study of Binimetinib in Children and Adults with NF1 associated Plexiform Neurofibromas (PNOC010)

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  • Phase I-II Study of MEK 162 for Children with Low-Grade Gliomas and Other Ras/Raf/ERK Pathway Activated Tumors

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  • APEC1621C: NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Phase 2 Subprotocol of Tazemetostat in Patients with Tumors Harboring Alterations in EZH2 or Members of the SWI/SNF Complex

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View All Research Studies (8)

Publications

  • Osorio, Diana S; Hu, Jessica; Mitchell, Carole; Allen, Jeffrey C; Stanek, Joseph; Hagiwara, Mari; Karajannis, Matthias A

    Journal of neuro-oncology. 2018 Sep 28; 139(3):749-755

  • Kim, Edward S; Bruinooge, Suanna S; Roberts, Samantha; Ison, Gwynn; Lin, Nancy U; Gore, Lia; Uldrick, Thomas S; Lichtman, Stuart M; Roach, Nancy; Beaver, Julia A; Sridhara, Rajeshwari; Hesketh, Paul J; Denicoff, Andrea M; Garrett-Mayer, Elizabeth; Rubin, Eric; Multani, Pratik; Prowell, Tatiana M; Schenkel, Caroline; Kozak, Marina; Allen, Jeff; Sigal, Ellen; Schilsky, Richard L

    Journal of clinical oncology. 2017 Nov 20; 35(33):3737-3744

  • MULTICENTER, PHASE 2 STUDY OF BEVACIZUMAB IN CHILDREN AND ADULTS WITH NEUROFIBROMATOSIS 2 AND PROGRESSIVE VESTIBULAR SCHWANNOMAS: AN NF CLINICAL TRIALS CONSORTIUM STUDY [Meeting Abstract]

    Plotkin, Scott; Tonsgard, James; Ullrich, Nicole; Allen, Jeffrey; Blakeley, Jashri; Rosser, Tena; Campian, Jian; Clapp, Wade; Fisher, Michael; Cutter, Gary; Korf, Bruce; Packer, Roger; Thomas, Coretta; Karjannis, Matthias

    Neuro-oncology. 2017 NOV; 19:215-215

Read All Publications (346)