Matthias C. Kugler, MD

  • Specialty: Pulmonary Medicine
  • Languages: English, German
  • Phone: 212-598-6351

Credentials

Positions
  • Assistant Professor, Department of Medicine
Board Certifications
  • American Board of Internal Medicine (Critical Care Medicine), 2012
  • American Board of Internal Medicine (Pulmonary Disease), 2011
  • American Board of Internal Medicine - Internal Medicine, 2009
Education and Training
  • Fellowship, NYU School of Medicine, Pulm & Critical Care, 2012
  • Residency, NYU School of Medicine, Internal Medicine, 2009
  • MD from Technical Uni Of Munchen, 2003
Departments

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Locations and Appointments

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NYU Critical Care Assocs

301 East 17th Street
New York, NY 10003

NYU Critical Care Associates

550 1st Avenue
New York, NY 10016

Research My Research

Interests

adult fibrosing lung diseases, idiopathic pulmonary fibrosis, IPF

Research Summary

Two areas of interest evolved from my research and clinical activities. On the cell biology level, I am interested in how cell surface receptors communicate with their environment in physiologic and pathophysiologic states. The functional consequences of altered signaling are of particular interest for me as a physician since they give me further insight into disease mechanisms, such as aberrant integrin or growth factor receptor signaling in pulmonary fibrosis. On the clinical level, I have become particularly interested in IPF (idiopathic pulmonary fibrosis), a fatal, progressive lung disease with unpredictable clinical course, a median survival of <4 years and no effective treatment. Despite extensive research its underlying mechanisms remain unclear. One potential way I have studied involves EMT. In EMT, epithelial cell injury induces phenotype change to a mesenchymal type, resulting in interstitial matrix accumulation in alveolar walls and progressive pulmonary fibrosis with loss of function. Another potential mechanism I am currently studying involves embryonic signaling pathways, such as Hedgehog (HH) signaling, which are usually suppressed in adult uninjured lung, but might become reactivated as pathogenic mechanism in IPF.

In our lab we have shown HH pathway reactivation in lung fibroblasts in two important settings: (1) during alveolar septum formation in the postnatal lung and (2) in bleomycin-injured fibrotic lung. In the early postnatal developmental setting, inhibition of HH signaling produced alveolar airspace enlargement and septum wall thinning without affecting septum formation. This indicates the importance of precise temporal decrease in mesenchyme for normal lung structure. In the pathophysiological setting, the exacerbation of bleomycin-induced fibrosis by SHH over-expression implies that aberrant pathway activity prevents the demise of lung fibroblasts during fibrosis resolution.

The long-term goals of my work are to better understand the molecular signatures of pulmonary fibrosis by studying their characteristics in pathophysiologically relevant mouse models to elucidate novel mechanisms and improve treatment options.

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • Sonic Hedgehog Signaling Regulates Myofibroblast Function During Alveolar Septum Formation in Murine Postnatal Lung

    Kugler, Matthias C; Loomis, Cynthia A; Zhao, Zhicheng; Cushman, Jennifer C; Liu, Li; Munger, John S Kugler, Matthias C; Loomis, Cynthia A; Zhao, Zhicheng; Cushman, Jennifer C; Liu, Li; Munger, John S
    American journal of respiratory cell & molecular biology. 2017 Sep . 57 (3): 280-293

  • Sonic Hedgehog Signaling Regulates Alveolarization During Postnatal Lung Development [Meeting Abstract]

    Kugler, MC; Loomis, CA; Yie, T-A; Munger, JS Kugler, MC; Loomis, CA; Yie, T-A; Munger, JS
    American journal of respiratory & critical care medicine. 2017. 195: ?-?

  • Sonic Hedgehog (shh) Signaling Regulates Myofibroblast Function During Alveolar Septum Formation In Postnatal Lung [Meeting Abstract]

    Kugler, MC; Loomis, CA; Ramos, J; Joyner, AL; Rom, WN; Rifkin, DB; Munger, J Kugler, MC; Loomis, CA; Ramos, J; Joyner, AL; Rom, WN; Rifkin, DB; Munger, J
    American journal of respiratory & critical care medicine. 2016. 193: ?-?

Read All Publications (15)