David Keefe, MD

  • Specialties: Reproductive Endocrinology and Infertility, Gynecology
  • Languages: English, Portuguese
  • Phone: 212-263-3360

About Me

Growing up as one of eight children, I learned the value of collaboration and teamwork. My wife and I are also very fortunate to have seven children, so I truly understand the importance of family to my patients.

Obstetrics and gynecology, and especially my focus on infertility, bring together the science and personal interactions with patients, which I love. I am incredibly invested in helping couples discover why they’ve been unable to conceive. At NYU Langone, we offer some of the most exciting fertility breakthroughs of our time, including the latest fertility drugs and genetic testing, to support couples in creating the families they want. 

Before I practiced as an OB/GYN, I trained in psychiatry, which prepared me to help couples cope with the emotions that accompany reproductive choices. I empower my patients to be involved in the entire process, and I help them to weigh their options based on their unique values and goals.

Breakthroughs in contraceptive technology have given women the ability to delay having children, but by a woman’s late 30s and early 40s, the ability to conceive declines. Our research lab focuses on the causes of age-related infertility, primarily the aging of the eggs themselves. We’re working on new treatments to slow this process. We’ve also made incredible advances in in vitro fertilization, including our ability to decrease the likelihood of miscarriage by using genetic testing of the embryo to determine its integrity before transfer.

Conditions and Treatments

in vitro fertilization (IVF), female infertility, egg freezing, ovulation induction, recurrent miscarriage, male infertility, polycystic ovary syndrome (PCOS), menstrual disorders, ectopic pregnancy, endometriosis, premature menopause, menopause, excessive hairiness, fibroid tumor, oocyte recovery, surrogate mothers, oocyte donation, artificial insemination, preimplantation diagnosis, fertility, fertility preservation
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  • Stanley H. Kaplan Professor and Chairman of Obstetrics and Gynecology, Department of Obstetrics and Gynecology
  • Professor, Department of Cell Biology
  • Stanley H Kaplan Chr Dept Obstertrics & Gynecology
Education and Training
  • Fellowship, Yale University School of Medicine, Reproductive Endocrinology, 1992
  • Fellowship, Yale University School of Medicine, Reproductive Endocrinology, 1991
  • Residency, Yale New Haven Hospital, Obstetrics & Gynecology, 1989
  • Fellowship, Northwestern University, Neuro-endocrinology, 1985
  • Residency, University of Chicago, Psychiatry, 1985
  • Residency, Cambridge Hospital, Psychiatry, 1982
  • Residency, Mount Auburn Hospital, Medicine, 1981
  • MD from Georgetown University, 1980

Locations and Appointments

6 Insurance Plans Accepted
  • Aetna HMO
  • Aetna POS
  • Aetna PPO/EPO
  • Oxford Freedom
  • Oxford Liberty
  • UnitedHealthcare Top Tier
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.
NYU Fertility Center

660 First Ave, FL 5
New York, NY 10016


Phone: 212-263-3360

Welcome back!

As a returning patient for this doctor, please schedule an appointment using your MyChart at NYU Langone account.

Learn more about MyChart at NYU Langone.

My Research

Fertility in women declines by their mid to late thirties, even while menses are regular and the rest of the body functions at near peak capacity. During this time the chance of pregnancy decreases and the chance of miscarriage increases, related to chromosome and other abnormalities in the eggs. My research group studies why a woman's eggs lose viability. We discovered changes in the chromosomes' ends, called the telomeres. We found that telomere attrition may contribute to the decreased fertility, as well as the increased miscarriage and aneuploidy risks observed in older women. We are developing tests of egg health based on measurement of telomere length. We also have shown in experimental animals that preventing telomere attrition may delay reproductive aging.Finally, we are using genomic approaches to identify the genes that influence telomere length and reproductive longevity in women.


  • Murine models of chemotherapy-induced primary ovarian insufficiency (POI) and age-related diminished ovarian reserve (DOR) reveal similar ovarian follicular dynamics and 'follicular exhaustion' [Meeting Abstract]

    Goldman, K N; Keefe, D; Dinardo, B; Grifo, J A; Schneider, R
    Reproductive sciences (Thousand Oaks, Calif.). 2016 March 2016. 23 (1): 91A-91A

  • Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs

    Yang, Jiao; Guo, Renpeng; Wang, Hua; Ye, Xiaoying; Zhou, Zhongcheng; Dan, Jiameng; Wang, Haiying; Gong, Peng; Deng, Wei; Yin, Yu; Mao, ShiQing; Wang, Lingbo; Ding, Junjun; Li, Jinsong; Keefe, David L; Dawlaty, Meelad M; Wang, Jianlong; Xu, GuoLiang; Liu, Lin
    Cell reports. 2016 May 12. 15 (8): 1809-1821

  • A single-cell assay for telomere DNA content shows increasing telomere length heterogeneity, as well as increasing mean telomere length in human spermatozoa with advancing age

    Antunes, Danielle M F; Kalmbach, Keri H; Wang, Fang; Dracxler, Roberta C; Seth-Smith, Michelle L; Kramer, Yael; Buldo-Licciardi, Julia; Kohlrausch, Fabiana B; Keefe, David L
    Journal of assisted reproduction & genetics. 2015 Sep 28. 32 (11): 1685-1690

Read All Publications (145)