David Keefe, MD

  • Specialties: Reproductive Endocrinology and Infertility, Gynecology
  • Languages: English, Portuguese
  • Phone: 212-263-3360

About Me

Growing up as one of eight children, I learned the value of collaboration and teamwork. My wife and I are also very fortunate to have seven children, so I truly understand the importance of family to my patients.

Obstetrics and gynecology, and especially my focus on infertility, bring together the science and personal interactions with patients, which I love. I am incredibly invested in helping couples discover why they’ve been unable to conceive. At NYU Langone, we offer some of the most exciting fertility breakthroughs of our time, including the latest fertility drugs and genetic testing, to support couples in creating the families they want. 

Before I practiced as an OB/GYN, I trained in psychiatry, which prepared me to help couples cope with the emotions that accompany reproductive choices. I empower my patients to be involved in the entire process, and I help them to weigh their options based on their unique values and goals.

Breakthroughs in contraceptive technology have given women the ability to delay having children, but by a woman’s late 30s and early 40s, the ability to conceive declines. Our research lab focuses on the causes of age-related infertility, primarily the aging of the eggs themselves. We’re working on new treatments to slow this process. We’ve also made incredible advances in in vitro fertilization, including our ability to decrease the likelihood of miscarriage by using genetic testing of the embryo to determine its integrity before transfer.


Conditions and Treatments

in vitro fertilization (IVF), female infertility, egg freezing, ovulation induction, recurrent miscarriage, male infertility, polycystic ovary syndrome (PCOS), menstrual disorders, ectopic pregnancy, endometriosis, premature menopause, menopause, excessive hairiness, fibroid tumor, oocyte donation, oocyte recovery, surrogate mothers, fertility preservation, artificial insemination, fertility, preimplantation diagnosis
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Credentials

Positions
  • Stanley H. Kaplan Professor and Chairman of Obstetrics and Gynecology, Department of Obstetrics and Gynecology
  • Professor, Department of Cell Biology
  • The Stanley H. Kaplan Professor and Chair, Department of Obstetrics and Gynecology
Board Certifications
  • American Board of Obstetrics & Gynecology (Reproduc Endocrin & Infertility), 1995
  • American Board of Obstetrics & Gynecology - Obstetrics & Gynecology, 1993
Education and Training
  • Fellowship, Yale University School of Medicine, Reproductive Endocrinology, 1992
  • Fellowship, Yale University School of Medicine, Reproductive Endocrinology, 1991
  • Residency, Yale New Haven Hospital, Obstetrics & Gynecology, 1989
  • Fellowship, Northwestern University, Neuro-endocrinology, 1985
  • Residency, University of Chicago, Psychiatry, 1985
  • Residency, Cambridge Hospital, Psychiatry, 1982
  • Residency, Mount Auburn Hospital, Medicine, 1981
  • MD from Georgetown University, 1980

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Locations and Appointments

View Insurance Plans Accepted
  • Aetna
    • Aetna HMO
    • Aetna POS
    • Aetna PPO/EPO
  • Empire Blue Cross Blue Shield
    • Empire Blue Cross Blue Shield EPO
    • Empire Blue Cross Blue Shield HMO
    • Empire Blue Cross Blue Shield Indemnity
    • Empire Blue Cross Blue Shield MediBlue
    • Empire Blue Cross Blue Shield POS
    • Empire Blue Cross Blue Shield PPO
    • Empire Blue Cross Blue Shield Pathways, Enhanced
  • Oxford
    • Oxford Freedom
    • Oxford Liberty
  • UHC
    • UnitedHealthcare Top Tier
NYU Fertility Center

660 First Ave, FL 5
New York, NY 10016

Research My Research

Interests

reproductive aging, oocyte dysfunction, telomeres, meiosis, stem cells, oocytes, genome integrity, stem cell biology

Research Summary

Fertility in women declines by their mid to late thirties, even while menses are regular and the rest of the body functions at near peak capacity. During this time the chance of pregnancy decreases and the chance of miscarriage increases, related to chromosome and other abnormalities in the eggs. My research group studies why a woman's eggs lose viability. We discovered changes in the chromosomes' ends, called the telomeres. We found that telomere attrition may contribute to the decreased fertility, as well as the increased miscarriage and aneuploidy risks observed in older women. We are developing tests of egg health based on measurement of telomere length. We also have shown in experimental animals that preventing telomere attrition may delay reproductive aging.Finally, we are using genomic approaches to identify the genes that influence telomere length and reproductive longevity in women.

Academic Contact

Academic office

462 First Avenue

Ninth Floor

New York, NY 10016

Phone

212-263-3360

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • Pregnancy Outcomes After Fertility Preservation in Transgender Men

    Maxwell, Susan; Noyes, Nicole; Keefe, David; Berkeley, Alan S; Goldman, Kara N Maxwell, Susan; Noyes, Nicole; Keefe, David; Berkeley, Alan S; Goldman, Kara N
    Obstetrics & gynecology. 2017 Jun . 129 (6): 1031-1034

  • Reconstitution of ovarian function following transplantation of primordial germ cells

    Zeng, Ming; Sheng, Xiaoyan; Keefe, David L; Liu, Lin Zeng, Ming; Sheng, Xiaoyan; Keefe, David L; Liu, Lin
    Scientific reports. 2017 May 03. 7 (1): 1427-1427

  • mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

    Goldman, Kara N; Chenette, Devon; Arju, Rezina; Duncan, Francesca E; Keefe, David L; Grifo, Jamie A; Schneider, Robert J Goldman, Kara N; Chenette, Devon; Arju, Rezina; Duncan, Francesca E; Keefe, David L; Grifo, Jamie A; Schneider, Robert J
    Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017 Mar 7. 114 (12): 3186-3191

Read All Publications (158)