Edwin H. Kolodny, MD

  • Specialties: Genetics, Neurology
  • Languages: English, French, German, Hebrew, Yiddish

Credentials

Positions
  • Research Professor, Department of Neurology
  • Professor Emeritus of Neurology, Department of Neurology
  • Dir Neurogenetics
Board Certifications
  • American Board of Colon & Rectal Surgery - Colon & Rectal Surgery, 1987
  • American Board of Medical Genetics - Medical Genetics, 1984
  • American Board of Medical Genetics - Clinical Genetics, 1984
  • American Board of Psychiatry & Neurology - Neurology, 1971
Education and Training
  • Fellowship, National Institute of Mental Health, Neurology, 1970
  • Residency, Massachusetts General Hospital, Neurology, 1967
  • Residency, Bellevue Hospital Center, Medicine, 1964
  • Residency, NYU Medical Center, 1964
  • MD from New York University, 1962
Departments

Locations and Appointments

11 Insurance Plans Accepted
  • Affinity
  • Affinity Exchange- Essential
  • HealthSmart (WTC)
  • MultiPlan/PHCS PPO
  • NY Medicaid
  • Oxford Exchange
  • Oxford Freedom
  • Oxford Liberty
  • Oxford Medicare
  • United Exchange- Compass
  • UnitedHealthcare Community & State Plan
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.

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My Research

A major focus of the Neurogenetics Laboratory is the study of the biochemical and molecular causes of inherited diseases and more effective means for their treatment. In the past few years, our laboratory has characterized a variety of novel mutations responsible for the GM2-gangliosidoses and globoid cell leukodystrophy. In vitro mutagenesis and transfection into COS cells allow us to clarify genotype: phenotype relationships in these and related lysosomal storage diseases and in animal models of these diseases. We are also involved in collaborations to investigate the gene loci for mucolipidosis IV and familial spastic paraparesis.

Gene therapy is being developed in our laboratory as a tool in the treatment of malignant brain tumor, Parkinson's disease and the lysosomal storage diseases. Glioma cells transduced with recombinant retroviruses expressing cytosine deaminase become sensitive to the prodrug 5-fluorocytosine and this effect is enhanced by interferons. Using this same suicide gene approach in combination with a vector, expressing both cytosine deaminase and thymidine kinase has enabled us to significantly prolong the survival of rats with rapidly growing intracerebral glioma. We also participate in a consortium devoted to the use of another form of gene therapy, bone marrow transplantation, to successfully treat globoid cell leukodystrophy.

Our work in lysosomal storage diseases has also led us to discover molecular mimicry between antiglycolipid antibodies found in various autoimmune diseases such as multiple sclerosis and certain proteins including p24 and gp120 of the HIV virus and various brain cell membrane components. The gene for one such protein, GCP, has been cloned and its structural relationship to the galactolipids is being investigated.

Publications

  • Cerebrovascular involvement in fabry disease: current status of knowledge

    Kolodny, Edwin; Fellgiebel, Andreas; Hilz, Max J; Sims, Katherine; Caruso, Paul; Phan, Thanh G; Politei, Juan; Manara, Renzo; Burlina, Alessandro
    Stroke. 2015 Jan. 46 (1): 302-313

  • GM1-gangliosidosis in American black bears: Clinical, pathological, biochemical and molecular genetic characterization

    Muthupalani, Sureshkumar; Torres, Paola A; Wang, Betty C; Zeng, Bai Jin; Eaton, Samuel; Erdelyi, Ildiko; Ducore, Rebecca; Maganti, Rajanikarath; Keating, John; Perry, Bain J; Tseng, Florina S; Waliszewski, Nicole; Pokras, Mark; Causey, Robert; Seger, Rita; March, Philip; Tidwell, Amy; Pfannl, Rolf; Seyfried, Thomas; Kolodny, Edwin H; Alroy, Joseph
    Molecular genetics & metabolism. 2014 Apr. 111 (4): 513-521

  • Lessons from everyday stroke care for clinical research and vice versa: comparison of a comprehensive and a research population of young stroke patients

    Tanislav, Christian; Grittner, Ulrike; Misselwitz, Bjoern; Jungehuelsing, Gerhard Jan; Enzinger, Christian; von Sarnowski, Bettina; Putaala, Jukka; Kaps, Manfred; Kropp, Peter; Rolfs, Arndt; Tatlisumak, Turgut; Fazekas, Franz; Kolodny, Edwin; Norrving, Bo
    BMC neurology. 2014. 14: 45-45

Read All Publications (343)