- Jeffrey Bergstein Professor of Medicine, Department of Medicine
- Professor, Department of Microbiology
- Professor, Department of Pathology
- Dir,Immunology and Inflammation Graduate Program
- Dir Division of Infectious Dis & Immunology
- American Board of Internal Medicine (Infectious Disease), 1999
Education and Training
- Fellowship, University of California - San Francisco, Hematology & Onc., 1984
- Fellowship, University of California - San Francisco, Infectious Diseases, 1982
The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.
Learn more about the Ernst Lab.
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection
Desvignes, Ludovic; Weidinger, Carl; Shaw, Patrick; Vaeth, Martin; Ribierre, Theo; Liu, Menghan; Fergus, Tawania; Kozhaya, Lina; McVoy, Lauren; Unutmaz, Derya; Ernst, Joel D; Feske, Stefan
Journal of clinical investigation. 2015 May. 125 (6): 2347-2362
Impaired M. tuberculosis Antigen-Specific IFN-gamma Response without IL-17 Enhancement in Patients with Severe Cavitary Pulmonary Tuberculosis
Fan, Lin; Xiao, Heping; Mai, Guangliang; Su, Bo; Ernst, Joel; Hu, Zhongyi
PLoS one. 2015. 10 (5): ?-? e0127087
Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo
Grace, Patricia S; Ernst, Joel D
Journal of immunology (1950). 2015 Nov. ?-?