Joel D. Ernst, MD

  • Specialty: Infectious Diseases & Immunology
  • Language: English

Credentials

Positions
  • Jeffrey Bergstein Professor of Medicine, Department of Medicine
  • Professor, Department of Pathology
  • Professor, Department of Microbiology
  • Dir,Immunology and Inflammation Graduate Program
  • Dir Division of Infectious Dis & Immunology
Board Certifications
  • American Board of Internal Medicine (Infectious Disease), 1999
Education and Training
  • Fellowship, University of California - San Francisco, Hematology & Onc., 1984
  • Fellowship, University of California - San Francisco, Infectious Diseases, 1982
  • MD from University Of Nebraska, 1978

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Research My Research

Interests

innate and adaptive immunity to intracellular bacteria, immunity to tuberculosis, whole genome sequencing, cancer, immunology, microbiology

Research Summary

The goal of the work in the Ernst Laboratory is to contribute to the eradication of tuberculosis, by understanding the mechanisms and limitations of immunity to tuberculosis and developing ways to make the immune response more effective. We develop and apply new tools adapted from immunology and bacterial genomics to study the impact of human immune responses on evolution of the bacteria, and use the information to inform new approaches to vaccine development. We also manipulate the bacterial genome, together with genetically-engineered mice, to obtain a deeper understanding of the mechanisms used by M. tuberculosis to evade recognition and elimination by host immune responses.

Learn more about the Ernst Lab.

Academic Contact

Academic office

Alexandria Center - West Tower, 430 East 29th Street

Room 304

New York, NY 10016

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Publications

  • "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report

    Boggiano, Cesar; Eichelberg, Katrin; Ramachandra, Lakshmi; Shea, Jaqueline; Ramakrishnan, Lalita; Behar, Samuel; Ernst, Joel D; Porcelli, Steven A; Maeurer, Markus; Kornfeld, Hardy Boggiano, Cesar; Eichelberg, Katrin; Ramachandra, Lakshmi; Shea, Jaqueline; Ramakrishnan, Lalita; Behar, Samuel; Ernst, Joel D; Porcelli, Steven A; Maeurer, Markus; Kornfeld, Hardy
    Vaccine. 2017 May 2. 35 (27): 3433-3440

  • Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya

    Arlehamn, Cecilia S Lindestam; Copin, Richard; Leary, Shay; Mack, Steven J; Phillips, Elizabeth; Mallal, Simon; Sette, Alessandro; Blatner, Gretta; Siefers, Heather; Ernst, Joel D Arlehamn, Cecilia S Lindestam; Copin, Richard; Leary, Shay; Mack, Steven J; Phillips, Elizabeth; Mallal, Simon; Sette, Alessandro; Blatner, Gretta; Siefers, Heather; Ernst, Joel D
    Human immunology. 2017 Mar 16. 78 (4): 325-326

  • Type I interferon is pathogenic during chronic Mycobacterium africanum infection

    Wiens, Kirsten E; Ernst, Joel D Wiens, Kirsten E; Ernst, Joel D
    Journal of infectious diseases. 2016 Dec 15. 214 (12): 1893-1896

Read All Publications (83)