David L. Kleinberg, MD

  • Specialty: Endocrinology
  • Language: English
  • Phone: 212-263-6772

About Me

Conditions and Treatments

prolactinoma, multiple endocrine neoplasia, diabetes insipidus, craniopharyngioma, cushing's syndrome, neuroendocrine tumor, subacute thyroiditis, adrenal tumor, hypogonadotropic hypogonadism, congenital adrenal hyperplasia, pheochromocytoma, hypopituitarism, adrenal insufficiency, pituitary adenoma, pituitary tumor, galactorrhea, acromegaly, pituitary disorders, adrenal gland disorders
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Credentials

Positions
  • Professor, Department of Medicine
  • Director Neuro Endocrine Unit
Board Certifications
  • American Board of Internal Medicine (Endocrinology, Diabetes & Metabolism), 1975
  • American Board of Internal Medicine - Internal Medicine, 1972
Education and Training
  • Residency, Columbia-Presbyterian Medical Center, Medicine, 1971
  • Fellowship, Columbia Presbysterian Medical Center, Endocrinology, 1970
  • Residency, Maimonides Medical Center, Internal Medicine, 1968
  • MD from University of Miami, 1966
Departments

Locations and Appointments

View Insurance Plans Accepted
  • Cigna
    • Cigna EPO/POS
    • Cigna PPO
  • UHC
    • UnitedHealthcare EPO
    • UnitedHealthcare HMO
    • UnitedHealthcare POS
    • UnitedHealthcare PPO
    • UnitedHealthcare Top Tier
David Kleinberg, M.D.

650 1st Avenue, 4th Floor
New York, NY 10016

Contact

Phone: 212-263-6772

Welcome back!

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Research My Research

Growth hormone and prolactin are pituitary hormones that are important in normal growth and development and in lactation post-partum. These hormones have protean effects on many cells and organ systems. We showed that development of the mammary gland is controlled initially by growth hormone and that prolactin has an important effect on the mammary gland at later developmental stages. In the absence of growth hormone, mammary development in rats and monkeys does not occur. Normal mammary development occurs at puberty under the influence of growth hormone and estrogen. Our research demonstrates that growth hormone works via the growth hormone receptor and stimulates local production of insulin-like growth factor I (IGF-I) within the mammary gland. That IGF-I then stimulates development of mammary gland terminal end buds and alveolar structures is supported by the fact that IGF-I can substitute for growth hormone in this process. Additionally, animals that are deficient in IGF-I do not have normal mammary development.

Our current work is to further uncover the mechanisms by which growth hormone stimulates mammary development and determine the interaction of hormones in various tissue types within the mammary gland. We hypothesize that a full under-standing of mammary development will help develop treatment for breast cancer.

Publications

  • The BRCA-1 polymorphism (major homozygous rs5820483) is associated with higher expression of phosphorylated -IGF-1 receptor [Meeting Abstract]

    Singh, B; Bochaca, I I; Ruiz, De Garibay G; Damiola, F; Mazoyer, S; Antoniou, A; Chenevix-Trench, G; Pujana, M A; Barcellos-Hoff, M H; Kleinberg, D Singh, B; Bochaca, I I; Ruiz, De Garibay G; Damiola, F; Mazoyer, S; Antoniou, A; Chenevix-Trench, G; Pujana, M A; Barcellos-Hoff, M H; Kleinberg, D
    Cancer research. 2016 15 Feb 2016. 76 (4):

  • Safety and Efficacy of Oral Octreotide in Acromegaly: Results of a Multicenter Phase III Trial

    Melmed, Shlomo; Popovic, Vera; Bidlingmaier, Martin; Mercado, Moises; van der Lely, Aart Jan; Biermasz, Nienke; Bolanowski, Marek; Coculescu, Mihail; Schopohl, Jochen; Racz, Karoly; Glaser, Benjamin; Goth, Miklos; Greenman, Yona; Trainer, Peter; Mezosi, Emese; Shimon, Ilan; Giustina, Andrea; Korbonits, Melmed, Shlomo; Popovic, Vera; Bidlingmaier, Martin; Mercado, Moises; van der Lely, Aart Jan; Biermasz, Nienke; Bolanowski, Marek; Coculescu, Mihail; Schopohl, Jochen; Racz, Karoly; Glaser, Benjamin; Goth, Miklos; Greenman, Yona; Trainer, Peter; Mezosi, Emese; Shimon, Ilan; Giustina, Andrea; Korbonits, Marta; Bronstein, Marcello D; Kleinberg, David; Teichman, Sam; Gliko-Kabir, Irit; Mamluk, Roni; Haviv, Asi; Strasburger, Christian
    Journal of clinical endocrinology & metabolism. 2015 Feb 9. 100 (4): 1699-1708
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  • Effects of low dose versus high dose human growth hormone on body composition and lipids in adults with GH deficiency: a meta-analysis of placebo-controlled randomized trials

    Newman, Connie B; Carmichael, John D; Kleinberg, David L Newman, Connie B; Carmichael, John D; Kleinberg, David L
    Pituitary. 2015 Jun . 18 (3): 297-305

Read All Publications (121)