David L. Kleinberg, MD

  • Specialty: Endocrinology
  • Language: English
  • Phone: 212-263-6772

About Me

Conditions and Treatments

craniopharyngioma, diabetes insipidus, prolactinoma, adrenal insufficiency, multiple endocrine neoplasia, pituitary tumor, galactorrhea, hypopituitarism, cushing's syndrome, pituitary disorders, pituitary adenoma, hypogonadotropic hypogonadism, neuroendocrine tumor, acromegaly
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  • Professor, Department of Medicine
  • Director Neuro Endocrine Unit

Board Certifications

  • American Board of Internal Medicine (Endocrinology, Diabetes & Metabolism)
  • American Board of Internal Medicine - Internal Medicine

Education and Training

  • 1971
  • Residency, Columbia-Presbyterian Medical Center, Medicine
  • 1970
  • Fellowship, Columbia Presbysterian Medical Center, Endocrinology
  • 1968
  • Residency, Maimonides Medical Center, Internal Medicine
  • 1966
  • MD from Univeristy Of Miami


Locations and Appointments

7 Insurance Plans Accepted
  • Cigna EPO/POS
  • Cigna PPO
  • UnitedHealthcare EPO
  • UnitedHealthcare HMO
  • UnitedHealthcare POS
  • UnitedHealthcare PPO
  • UnitedHealthcare Top Tier
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.

David Kleinberg, M.D.
650 1st Avenue, 4th Floor
New York, NY 10016


Phone: 212-263-6772

Welcome back!

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My Research

Growth Hormone and IGF-I in Mammary Development and Breast Cancer

Growth hormone and prolactin are pituitary hormones that are important in normal growth and development and in lactation post-partum. These hormones have protean effects on many cells and organ systems. We showed that development of the mammary gland is controlled initially by growth hormone and that prolactin has an important effect on the mammary gland at later developmental stages. In the absence of growth hormone, mammary development in rats and monkeys does not occur. Normal mammary development occurs at puberty under the influence of growth hormone and estrogen. Our research demonstrates that growth hormone works via the growth hormone receptor and stimulates local production of insulin-like growth factor I (IGF-I) within the mammary gland. That IGF-I then stimulates development of mammary gland terminal end buds and alveolar structures is supported by the fact that IGF-I can substitute for growth hormone in this process. Additionally, animals that are deficient in IGF-I do not have normal mammary development.

Our current work is to further uncover the mechanisms by which growth hormone stimulates mammary development and determine the interaction of hormones in various tissue types within the mammary gland. We hypothesize that a full under-standing of mammary development will help develop treatment for breast cancer.


  • Growth hormone should be used only for approved indications

    Clemmons, David R; Molitch, Mark; Hoffman, Andrew R; Klibanski, Anne; Strasburger, Christian J; Kleinberg, David L; Ho, Ken; Webb, Susan M; Bronstein, Marcello D; Bouillon, Roger; Ben-Shlomo, Anat; Hamrahian, Amir H; Chanson, Philippe; Barkan, Ariel L; Merriam, George R; Blackman, Marc R; Salvatori, Roberto 2014 Feb; 409-411, Journal of clinical endocrinology & metabolism — id: 806872, year: 2014, page: 409, stat: Journal Article
  • Expert consensus document: A consensus on the medical treatment of acromegaly

    Giustina, Andrea; Chanson, Philippe; Kleinberg, David; Bronstein, Marcello D; Clemmons, David R; Klibanski, Anne; van der Lely, Aart J; Strasburger, Christian J; Lamberts, Steven W; Ho, Ken K Y; Casanueva, Felipe F; Melmed, Shlomo 2014 Apr; 243-248, Nature reviews. Endocrinology — id: 851862, year: 2014, page: 243, stat: Journal Article
  • Acromegaly: assessing the disorder and navigating therapeutic options for treatment

    Melmed, Shlomo; Kleinberg, David L; Bonert, Vivien; Fleseriu, Maria 2014 Oct; 7-17, Endocrine practice — id: 1341282, year: 2014, page: 7, stat: Journal Article
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