Bruce N. Cronstein

  • Specialty: Rheumatology
  • Language: English
  • Phone: 212-263-6404


  • Dr. Paul R. Esserman Professor of Medicine, Department of Medicine
  • Professor, Department of Biochemistry and Molecular Pharmacology
  • Professor, Department of Pathology
  • Director Program in Collaborative Research
  • Dir Clinical Translational Science Inst
  • Dir Division of Translational Medicine
Board Certifications
  • American Board of Internal Medicine (Rheumatology), 1984
  • American Board of Internal Medicine - Internal Medicine, 1979
Education and Training
  • Fellowship, Bellevue Hospital Center, 1983
  • Fellowship, NYU Medical Center, 1983
  • Fellowship, Department of Veterans Affairs-New York Campus, 1983
  • Residency, Lenox Hill Hospital, Medicine (Internal), 1980
  • Residency, Department of Veterans Affairs-New York Campus, Pathology, 1978
  • Residency, NYU Medical Center, Pathology, 1978
  • Residency, Bellevue Hospital Center, Pathology, 1978

Locations and Appointments

461 First Avenue, 16N1
New York, NY 10016


Phone: 212-263-6404

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My Research

Adenosine is released from most cells and tissues as a result of ATP catabolism in response to such stresses as hypoxia and inflammatory injury. Adenosine regulates numerous physiologic functions via interaction with one or more of at least four known receptors (A1, A2A, A2B, A3), all of which are members of the family of G protein-coupled receptors. At least one adenosine receptor type, and generally more than one type, is expressed on nearly every cell type and tissue examined. We first demonstrated the presence and function of both A1 and A2 adenosine receptors on human polymorphonuclear leukocytes and their critical role in regulating inflammation. In more recent studies we have shown that adenosine, acting at its receptors, mediates the antiinflammatory effects of methotrexate, the most commonly used drug in the treatment of Rheumatoid Arthritis. My laboratory continues to explore the mechanism by which adenosine receptors modulate cellular functions. Inflammation is a critical first step in dealing with tissue injury and for preventing superinfection at wounded sites. Because inflammation is the first step in wound healing we asked whether adenosine receptor agonists might promote wound healing. We have demonstrated that topical application of adenosine A2A receptor agonists stimulates more rapid wound healing, a phenomenon we have helped take into the clinic where an adenosine A2A receptor agonist is undergoing clinical trials for the promotion of healing of diabetic foot ulcers. We have explored the mechanism by which adenosine A2A receptor agonists promote wound healing and found that occupancy of A2A receptors by adenosine or its more selective and potent agonists promotes new blood vessel formation and new matrix formation by fibroblasts. Thus, adenosine A2A receptor agonists may be useful in stimulating wound healing. Because adenosine A2A receptor agonists stimulate more rapid and exuberant wound healing we determined whether adenosine A2A receptors were involved in scar formation although the scarring we examined was in the liver. We found that adenosine A2A receptors play a critical role in animal models of liver fibrosis and that agents that block these receptors could be used to block the development of liver cirrhosis/fibrosis, an important public health problem. Current research in the laboratory is focused on understanding the molecular mechanisms by which adenosine concentrations are increased in the extracellular space and how adenosine and its receptors regulate inflammation, wound healing and fibrosis.


  • Adenosine A2B receptors play an important role in bone homeostasis

    Corciulo, Carmen; Wilder, Tuere; Cronstein, Bruce N
    Purinergic signalling. 2016 Jun 11. ?-?

  • Adenosine A2A Receptor (A2AR) Promotes Collagen Type 3 Expression Via s-Catenin Activation [Meeting Abstract]

    Shaikh, G; Perez-Aso, M; Mediero, A; Cronstein, B
    Journal of the American Academy of Dermatology. 2016 May 2016. 74 (5): AB31-AB31

  • Signaling pathways involving adenosine A and A receptors in wound healing and fibrosis

    Shaikh, Gibran; Cronstein, Bruce
    Purinergic signalling. 2016 Feb 4. 12 (2): 191-197

Read All Publications (255)