Jennifer A. Philips

  • Specialties: Infectious Diseases & Immunology, Virology
  • Language: English
  • Phone: 212-263-9181

Credentials

Positions
  • Assistant Professor, Department of Medicine
  • Assistant Professor, Department of Microbiology
  • Assistant Professor, Department of Pathology
  • Co-Director, Medical Scientist Training Program
Board Certifications
  • American Board of Internal Medicine (Infectious Disease), 2005
Education and Training
  • Fellowship, Massachusetts General Hospital, Infectious Diseases, 2006

Locations and Appointments

550 First Avenue
New York, NY 10016

Contact

Phone: 212-263-9181

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My Research

The Philips lab is interested in how mycobacteria survive in macrophages. One third of the world population is infected with Mycobacterium tuberculosis (M.tb), and it causes 2-3 million deaths yearly. The enormous worldwide burden of disease underscores the proficiency by which M.tb is able to evade eradication by the host, subverting innate and adaptive defenses. M.tb targets evolutionarily conserved molecules to survive within macrophages, cells that normally eradicate bacteria. We have employed genome-wide, high throughput strategies to identify both bacterial effectors and host factors that influence the outcome of infection in both model systems and mammalian macrophages.

The goal of the lab is to characterize the role of such factors during infection. Insight into M.tb-host interactions is sure to broaden our understanding of bacterial pathogenesis as well as eukaryotic cell biology and may ultimately translate into effective therapeutics more quickly than traditional strategies targeting bacterial factors.

Post-doctoral Positions Available: interested individuals should contact Jennifer.Philips@nyumc.org

Jennifer Philips, MD, lab website: Jennifer Philips Research

Publications

  • Autophagy meets phagocytosis

    Cadwell, Ken; Philips, Jennifer A
    Immunity. 2013 Sep. 39 (3): 425-427

  • Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking

    Mehra, Alka; Zahra, Aleena; Thompson, Victor; Sirisaengtaksin, Natalie; Wells, Ashley; Porto, Maura; Koster, Stefan; Penberthy, Kristen; Kubota, Yoshihisha; Dricot, Amelie; Rogan, Daniel; Vidal, Marc; Hill, David E; Bean, Andrew J; Philips, Jennifer A
    PLoS pathogens. 2013 Oct. 9 (10): e1003734-e1003734 e1003734

  • Tuberculosis Pathogenesis and Immunity

    Philips JA; Ernst JD
    Annual review of pathology. 2012 Feb. 7: 353-384

Read All Publications (14)