John G. Pappas, MD

  • Specialty: Pediatrics
  • Languages: English, Greek
  • Phone: 646-754-2222

About Me

My curiosity about science was heightened by a high school biology class, during which I wondered at the complex phenomena such simple elements—carbon, hydrogen, oxygen, and nitrogen—can create. Then the genetic code was discovered, and it seemed we suddenly had so many answers at our fingertips.

When I studied genetics in closer detail, however, I found more questions than answers. My interest in incurable diseases, especially those brought about by genes associated with unfavorable traits, grew during the years I studied in my home country, Greece, at the University of Athens. There, I discovered my passion: medical genetics. There was no specific program in Greece where I could further my training, so I moved to the United States and pursued pediatrics and genetics.

Helping families struggling with genetic conditions has become my priority. In my practice, I evaluate prenatal genetic abnormalities and offer prenatal counseling. I also evaluate children and adults with possible genetic disorders, including predisposition to cancer. I’m specifically interested in genomic microdeletions and microduplications—small mutations that are associated with different conditions, such as autism—and I hope to study these mutations in future research projects.

Patients and parents of patients often don’t realize that nature changes and distributes genes randomly. I try to eliminate the guilt that can accompany a genetic disease diagnosis by explaining that new mutations occur naturally, and that nobody has a choice in deciding which part of their DNA is transmitted to their kids.

It is fulfilling to be able to direct families, parents, and children with genetic conditions to the appropriate specialties. I love doing what I can to make their lives easier. I can empower families with the explanation that a DNA mutation is totally natural, untouchable by humans. Most of all, being a part of family discussions and decisions during personal, and sometimes very painful, times is a privilege and responsibility that extends beyond professional duties.

In addition to educating patients, I have a responsibility to educate students. I am actively involved in teaching first- and third-year medical students, as well as residents and fellows, about the main features of genetic syndromes, prompt communication of a diagnosis, and familiarity with advances in the field of medical genetics.

Conditions and Treatments

growth disorders, kabuki syndrome, multiple pterygium syndrome, connective tissue disease, craniosynostosis, epilepsy, movement disorders, multiple endocrine neoplasia, muscular dystrophy, neurofibromatosis, normal pressure hydrocephalus (nph), autism, intellectual disability, achondroplasia, arthrogryposis, birthmark, cleft palate, congenital heart defect, congenital hydrocephalus, cystic fibrosis, ear malformation, genetic skin diseases, inborn scoliosis, limb abnormalities, lysosomal storage disease, marfan syndrome, pseudoachondroplasia, short stature, coarctation, hand deformities, kidney malformation, vascular malformation
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  • Assistant Professor, Department of Pediatrics
Board Certifications
  • American Board of Medical Genetics - Clinical Genetics, 1996
Education and Training
  • Fellowship, Beth Israel Medical Center, Clinical Genetics, 1995
  • Residency, Beth Israel Medical Center, Pediatrics, 1991
  • MD from Athens University, 1985

Locations and Appointments

65 Insurance Plans Accepted
  • Aetna HMO
  • Aetna Indemnity
  • Aetna Medicare
  • Aetna POS
  • Aetna PPO/EPO
  • Affinity
  • Affinity Exchange- Essential
  • Cigna EPO/POS
  • Cigna PPO
  • ElderPlan
  • Empire Blue Cross Blue Shield EPO
  • Empire Blue Cross Blue Shield HMO
  • Empire Blue Cross Blue Shield HealthPlus
  • Empire Blue Cross Blue Shield HealthPlus Essential
  • Empire Blue Cross Blue Shield Indemnity
  • Empire Blue Cross Blue Shield MediBlue
  • Empire Blue Cross Blue Shield POS
  • Empire Blue Cross Blue Shield PPO
  • Empire Blue Cross Blue Shield Pathways, Enhanced
  • Fidelis Child Health
  • Fidelis Essential
  • Fidelis Exchange
  • Fidelis Family Health
  • Fidelis Medicaid
  • Fidelis Medicare
  • HIP Access I
  • HIP Access II
  • HIP Child Health
  • HIP Essential
  • HIP Family Health
  • HIP Medicaid
  • HIP Medicare
  • HealthSmart (WTC)
  • Healthfirst
  • Healthfirst Essential
  • Humana Medicare
  • Local 1199 PPO
  • MagnaCare PPO
  • Medicare
  • MultiPlan/PHCS PPO
  • NY Medicaid
  • NYS Empire Plan
  • Oscar
  • Oxford Freedom
  • Oxford Liberty
  • Oxford Medicare
  • PHP
  • UPN Elite
  • UnitedHealthcare Community & State Plan
  • UnitedHealthcare Core and Charter
  • UnitedHealthcare EPO
  • UnitedHealthcare HMO
  • UnitedHealthcare Medicare
  • UnitedHealthcare POS
  • UnitedHealthcare PPO
  • UnitedHealthcare Top Tier
  • Village Caremax
  • Visiting Nurse Service (VNS) Medicare
  • WellCare Child Health
  • WellCare Family Health
  • WellCare Medicare
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.
NYU Pediatric Genetics Associates

145 East 32nd Street, 14th Floor
New York, NY 10016

Center for Children-Genetics Clinic

301 East 17th Street
New York, NY 10003

Welcome back!

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Learn more about MyChart at NYU Langone.


  • Expansion of phenotype and genotypic data in CRB2-related syndrome

    Lamont, Ryan E; Tan, Wen-Hann; Innes, A Micheil; Parboosingh, Jillian S; Schneidman-Duhovny, Dina; Rajkovic, Aleksandar; Pappas, John; Altschwager, Pablo; DeWard, Stephanie; Fulton, Anne; Gray, Kathryn J; Krall, Max; Mehta, Lakshmi; Rodan, Lance H; Saller, Devereux N Jr; Steele, Deanna; Stein, Deborah; Yatsenko, Svetlana A; Bernier, Francois P; Slavotinek, Anne M
    European journal of human genetics. 2016 Mar 23. ?-?

  • Potocki-Lupski syndrome in conjunction with bilateral clubfoot

    Dhanaraj, Dinesh; Chu, Alice; Pappas, John G; Moran, Ellen; Lehman, Wallace B
    Journal of pediatric orthopaedics. Pt. B. 2015 Jul . 24 (4): 373-376

  • De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy

    Esmaeeli Nieh, Sahar; Madou, Maura R Z; Sirajuddin, Minhajuddin; Fregeau, Brieana; McKnight, Dianalee; Lexa, Katrina; Strober, Jonathan; Spaeth, Christine; Hallinan, Barbara E; Smaoui, Nizar; Pappas, John G; Burrow, Thomas A; McDonald, Marie T; Latibashvili, Mariam; Leshinsky-Silver, Esther; Lev, Dorit; Blumkin, Luba; Vale, Ronald D; Barkovich, Anthony James; Sherr, Elliott H
    Annals of clinical & translational neurology. 2015 May 1. 2 (6): 623-635

Read All Publications (32)