Douglas A. Levine, MD

  • Specialty: Gynecologic Oncology
  • Language: English
  • Phone: 646-501-4834

About Me

I am a board-certified gynecologic oncologist who specializes in the surgical treatment of women with known or suspected ovarian and endometrial cancers. For most women who have these gynecologic cancers, surgery is an important part of the initial treatment and increases the possibility of long-term success. Every time I enter the operating room, my entire focus and effort is directed toward completely removing the cancer.

A diagnosis of ovarian cancer can be very challenging for women and their families. Together, we create an individualized treatment plan that incorporates the latest knowledge in ovarian cancer therapy, both in the operating room and beyond. My teamwork approach to ovarian cancer therapy coupled with years of expertise allows my patients to benefit from the most advanced surgical and medical treatments.

In addition to my expertise in surgical management of advanced ovarian and endometrial cancers, I also have special training in minimally invasive surgery—laparoscopy and robotic surgery—and preventive surgery for selected patients. I incorporate chemotherapy that can be delivered directly into the abdomen for women who have advanced ovarian cancer. For women with recurrent ovarian cancer, I can use genomic testing to analyze tumors and develop individualized therapies. I use precision medicine to create better treatment options for all women who have ovarian cancer.

In my laboratory at NYU Langone, I focus on precision medicine, rare tumors, and early detection and prevention of gynecologic cancers. We are currently leading the development of national clinical trials for ovarian cancer prevention. We are also working to understand which women are most likely to respond to treatment with anticancer drugs so we can direct the best treatments toward the most appropriate patients. My research has been supported by the National Cancer Institute, the Department of Defense, Stand Up to Cancer, the Ovarian Cancer Research Fund, the Foundation for Women’s Cancer, the Entertainment Industry Foundation, and Cycle for Survival. 

I have authored or coauthored more than 160 peer-reviewed research papers, reviewed articles, and book chapters. I am the founding editor of Atlas of Procedures in Gynecologic Oncology, and I serve on the scientific advisory committee of the Ovarian Cancer Research Fund and the Clearity Foundation. I am also a special advisor to the board of directors of the Honorable Tina Brozman Foundation and the co-chair of the ovarian cancer, endometrial cancer, and uterine carcinosarcoma working groups for The Cancer Genome Atlas. I was honored to receive the Mentor Award from the American Congress of Obstetricians and Gynecologists in 2012 and the Foundation for Women’s Cancer’s Excellence in Ovarian Cancer Research Prize in 2013.


Conditions and Treatments

cancer screening, cervical cancer, uterine cancer, gynecologic cancer, cervical cancer screening, vaginal cancer, tumor of uterine muscle, ovarian cancer, cancer surgery, vulvar cancer, ovarian cancer screening
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Credentials

Positions
  • Professor, Department of Obstetrics and Gynecology
  • Director, Division of Gynecologic Oncology
Board Certifications
  • American Board of Obstetrics & Gynecology (Gynecologic Oncology), 2007
  • American Board of Obstetrics & Gynecology - Obstetrics & Gynecology, 2005
Education and Training
  • Fellowship, Memorial Sloan Kettering Cancer Center, Gynecologic Oncology, 2004
  • Residency, Icahn School of Medicine at Mount Sinai, Obstetrics & Gynecology, 1999
  • MD from Mount Sinai School Of Medicine, 1995

Locations and Appointments

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NYU Langone Laura and Isaac Perlmutter Cancer Center

240 East 38th Street, 19th Floor
New York, NY 10016

Welcome back!

As a returning patient for this doctor, please schedule an appointment using your MyChart at NYU Langone account.

Learn more about MyChart at NYU Langone.

Research My Research

My research is primarily focused on ovarian and endometrial cancers. The broad aim of this work is to develop novel biomarkers, expand the use of precision medicine, and understand rare tumors.

One particular area of interest is early detection and prevention of ovarian cancer. We are applying next generation sequencing to circulating and shed biomarkers in order to develop better approaches for primary, secondary, and tertiary ovarian cancer prevention. Primary prevention measures often involve surgical procedures, whereas secondary and tertiary prevention can capitalize on newly discovered biomarkers.

My colleagues and I are actively engaged in translational research that applies precision medicine to ongoing and completed clinical trials. We interrogate tumor specimens and companion normal tissue to determine what molecular features associate with patient responses in the context of an institutional or cooperative group clinical trial. We are also applying these techniques to model systems in order to identify patient subgroups that are uniquely sensitive or resistant to targeted therapies, such as PARP inhibitors or immune checkpoint blockade.

In recent years, my laboratory has discovered driver mutations for rare tumor types. We are elucidating the underlying mechanisms that permit these tumors to develop and spread. We are also developing biologic models for these rare tumors to help with drug development and to share with other scientists throughout the world so that collectively we can advance the fight against these rare tumors. 

As division director of gynecologic oncology, I have also overseen the development of our clinical trial portfolio and the translational research program.

Publications

  • Integrated Molecular Characterization of Uterine Carcinosarcoma

    Cherniack, Andrew D; Shen, Hui; Walter, Vonn; Stewart, Chip; Murray, Bradley A; Bowlby, Reanne; Hu, Xin; Ling, Shiyun; Soslow, Robert A; Broaddus, Russell R; Zuna, Rosemary E; Robertson, Gordon; Laird, Peter W; Kucherlapati, Raju; Mills, Gordon B; Weinstein, John N; Zhang, Jiashan; Akbani, Rehan; Levine, Cherniack, Andrew D; Shen, Hui; Walter, Vonn; Stewart, Chip; Murray, Bradley A; Bowlby, Reanne; Hu, Xin; Ling, Shiyun; Soslow, Robert A; Broaddus, Russell R; Zuna, Rosemary E; Robertson, Gordon; Laird, Peter W; Kucherlapati, Raju; Mills, Gordon B; Weinstein, John N; Zhang, Jiashan; Akbani, Rehan; Levine, Douglas A
    Cancer cell. 2017 Mar 13. 31 (3): 411-423
    Show More Authors

  • Optimal primary management of bulky stage IIIC ovarian, fallopian tube and peritoneal carcinoma: Are the only options complete gross resection at primary debulking surgery or neoadjuvant chemotherapy?

    Sioulas, Vasileios D; Schiavone, Maria B; Kadouri, David; Zivanovic, Oliver; Roche, Kara Long; O'Cearbhaill, Roisin; Abu-Rustum, Nadeem R; Levine, Douglas A; Sonoda, Yukio; Gardner, Ginger J; Leitao, Mario M Jr; Chi, Dennis S Sioulas, Vasileios D; Schiavone, Maria B; Kadouri, David; Zivanovic, Oliver; Roche, Kara Long; O'Cearbhaill, Roisin; Abu-Rustum, Nadeem R; Levine, Douglas A; Sonoda, Yukio; Gardner, Ginger J; Leitao, Mario M Jr; Chi, Dennis S
    Gynecologic oncology. 2017 Feb 21. 145 (1): 15-20

  • The EMSY threonine 207 phospho-site is required for EMSYdriven suppression of DNA damage repair

    Jelinic, Petar; Eccles, Laura A; Tseng, Jill; Cybulska, Paulina; Wielgos, Monicka; Powell, Simon N; Levine, Douglas A Jelinic, Petar; Eccles, Laura A; Tseng, Jill; Cybulska, Paulina; Wielgos, Monicka; Powell, Simon N; Levine, Douglas A
    Oncotarget. 2017 Jan 13. ?-?

Read All Publications (210)