Douglas A. Levine, MD

  • Specialty: Gynecologic Oncology
  • Language: English
  • Phone: 646-501-4834
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About Me

I am a board-certified gynecologic oncologist who specializes in the surgical treatment of women with known or suspected ovarian and endometrial cancers. For most women who have these gynecologic cancers, surgery is an important part of the initial treatment and increases the possibility of long-term success. Every time I enter the operating room, my entire focus and effort is directed toward completely removing the cancer.

A diagnosis of ovarian cancer can be very challenging for women and their families. Together, we create an individualized treatment plan that incorporates the latest knowledge in ovarian cancer therapy, both in the operating room and beyond. My teamwork approach to ovarian cancer therapy coupled with years of expertise allows my patients to benefit from the most advanced surgical and medical treatments.

In addition to my expertise in surgical management of advanced ovarian and endometrial cancers, I also have special training in minimally invasive surgery—laparoscopy and robotic surgery—and preventive surgery for selected patients. I incorporate chemotherapy that can be delivered directly into the abdomen for women who have advanced ovarian cancer. For women with recurrent ovarian cancer, I can use genomic testing to analyze tumors and develop individualized therapies. I use precision medicine to create better treatment options for all women who have ovarian cancer.

In my laboratory at NYU Langone, I focus on precision medicine, rare tumors, and early detection and prevention of gynecologic cancers. We are currently leading the development of national clinical trials for ovarian cancer prevention. We are also working to understand which women are most likely to respond to treatment with anticancer drugs so we can direct the best treatments toward the most appropriate patients. My research has been supported by the National Cancer Institute, the Department of Defense, Stand Up to Cancer, the Ovarian Cancer Research Fund, the Foundation for Women’s Cancer, the Entertainment Industry Foundation, and Cycle for Survival. 

I have authored or coauthored more than 160 peer-reviewed research papers, reviewed articles, and book chapters. I am the founding editor of Atlas of Procedures in Gynecologic Oncology, and I serve on the scientific advisory committee of the Ovarian Cancer Research Fund and the Clearity Foundation. I am also a special advisor to the board of directors of the Honorable Tina Brozman Foundation and the co-chair of the ovarian cancer, endometrial cancer, and uterine carcinosarcoma working groups for The Cancer Genome Atlas. I was honored to receive the Mentor Award from the American Congress of Obstetricians and Gynecologists in 2012 and the Foundation for Women’s Cancer’s Excellence in Ovarian Cancer Research Prize in 2013.


Conditions and Treatments

ovarian cancer, fallopian tube cancer, uterine cancer, endometrial cancer, gynecologic cancer, ovarian cancer surgery, minimally invasive surgery, robotic surgery, cancer surgery, gynecological surgery, endometrial hyperplasia, vaginal cancer, cervical cancer screening, vulvar cancer, cervical cancer, cancer screening, tumor of uterine muscle, ovarian cancer screening
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Credentials

Positions
  • Professor, Department of Obstetrics and Gynecology
  • Director, Division of Gynecologic Oncology
Board Certifications
  • American Board of Obstetrics & Gynecology (Gynecologic Oncology), 2007
  • American Board of Obstetrics & Gynecology - Obstetrics & Gynecology, 2005
Education and Training
  • Fellowship, Memorial Sloan Kettering Cancer Center, Gynecologic Oncology, 2002
  • Residency, Icahn School of Medicine at Mount Sinai, Obstetrics & Gynecology, 1999
  • MD from Mount Sinai School of Medicine, 1995

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NYU Langone Laura and Isaac Perlmutter Cancer Center

240 East 38th Street, 19th Floor
New York, NY 10016

Research My Research

Research Summary

My research primarily focuses on ovarian and endometrial cancers. The broad aims of my work are to develop novel biomarkers, expand the use of precision medicine, and understand rare tumors.

Of particular interest are the early detection and prevention of ovarian cancer. We use next-generation sequencing to analyze circulating and shed biomarkers in order to develop better approaches for primary, secondary, and tertiary ovarian cancer prevention. Primary prevention often involves surgical procedures, but secondary and tertiary prevention can capitalize on newly discovered biomarkers.

My colleagues and I are also engaged in translational research, where we apply precision medicine techniques in ongoing and completed clinical trials. We study tumor specimens and companion normal tissues to determine the molecular features—including DNA mutations, epigenetics, transcriptomics, and proteomics— associated with specific patient responses. We also apply these techniques to model systems in order to identify subgroups of patients who are uniquely sensitive or resistant to targeted therapies, such as poly (ADP-ribose) polymerase (PARP) inhibitors or immune checkpoint blockade.

In recent years, my laboratory has discovered driver mutations, which confer a selective growth advantage and thus promote cancer development, for certain rare tumor types.

We recently discovered universal SMARCA4 gene mutations that appear to be a critical driver for a very aggressive form of cancer that affects young women—small-cell carcinoma of the ovary, hypercalcemic type. The SMARCA4 encodes a catalytic ATPase subunit of the SWI/SNF chromatin remodeling complex. We subsequently determined that expression of the SMARCA2 protein, another catalytic subunit of this complex, is also lost in all of these tumors. In most other solid tumors with a SWI/SNF loss, a compensatory upregulation of other members of this protein complex counteracts the functional loss of any single component. We continue to investigate the remarkable concurrent loss of both catalytic ATPase SWI/SNF subunits to better understand this disease pathogenesis.

We are elucidating the mechanisms that permit these tumors to develop and spread. We are advancing the fight against these rare tumors by developing biological models to help with drug development and to share with scientists worldwide.

As division director of gynecologic oncology, I have also overseen the development of our clinical trial portfolio and the translational research program.

Academic Contact

Academic office

240 East 38th Street

Nineteenth Floor

New York, NY 10016

Phone

646-501-4834

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Clinical Trials

  • Women Choosing Surgical Prevention
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  • Multi-gene panel testing in ovarian cancer.
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  • A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042 an anti-PD-1 Monoclonal Antibody in Patients with Advanced Solid Tumors
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Publications

  • Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma

    Ducie, Jennifer; Dao, Fanny; Considine, Michael; Olvera, Narciso; Shaw, Patricia A; Kurman, Robert J; Shih, Ie-Ming; Soslow, Robert A; Cope, Leslie; Levine, Douglas A Ducie, Jennifer; Dao, Fanny; Considine, Michael; Olvera, Narciso; Shaw, Patricia A; Kurman, Robert J; Shih, Ie-Ming; Soslow, Robert A; Cope, Leslie; Levine, Douglas A
    Nature communications. 2017 Oct 17. 8 (1): 990-990

  • Genetic predisposition to bevacizumab-induced hypertension

    Frey, Melissa K; Dao, Fanny; Olvera, Narciso; Konner, Jason A; Dickler, Maura N; Levine, Douglas A Frey, Melissa K; Dao, Fanny; Olvera, Narciso; Konner, Jason A; Dickler, Maura N; Levine, Douglas A
    Gynecologic oncology. 2017 Sep 29. ?-?

  • Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

    Haemmerle, Monika; Taylor, Morgan L; Gutschner, Tony; Pradeep, Sunila; Cho, Min Soon; Sheng, Jianting; Lyons, Yasmin M; Nagaraja, Archana S; Dood, Robert L; Wen, Yunfei; Mangala, Lingegowda S; Hansen, Jean M; Rupaimoole, Rajesha; Gharpure, Kshipra M; Rodriguez-Aguayo, Cristian; Yim, Sun Young; Lee, Ju-Seog; Haemmerle, Monika; Taylor, Morgan L; Gutschner, Tony; Pradeep, Sunila; Cho, Min Soon; Sheng, Jianting; Lyons, Yasmin M; Nagaraja, Archana S; Dood, Robert L; Wen, Yunfei; Mangala, Lingegowda S; Hansen, Jean M; Rupaimoole, Rajesha; Gharpure, Kshipra M; Rodriguez-Aguayo, Cristian; Yim, Sun Young; Lee, Ju-Seog; Ivan, Cristina; Hu, Wei; Lopez-Berestein, Gabriel; Wong, Stephen T; Karlan, Beth Y; Levine, Douglas A; Liu, Jinsong; Afshar-Kharghan, Vahid; Sood, Anil K
    Nature communications. 2017 Aug 21. 8 (1): 310-310
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Read All Publications (219)