Jonathan D. Brodie, MD, PhD

  • Specialty: Adult Psychiatry
  • Language: English
  • Phone: 212-986-6693

Credentials

Positions
  • Research Professor, Department of Psychiatry
  • Professor Emeritus of Psychiatry, Department of Psychiatry
Board Certifications
  • American Board of Psychiatry & Neurology - Psychiatry, 1979
Education and Training
  • Residency, NYU Medical Center, Psychiatry, 1978
  • MD from New York University, 1975
  • PhD from University Of Wisconsin, 1962
Departments

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Locations and Appointments

2 Insurance Plans Accepted
  • HealthNet
  • UnitedHealthcare Top Tier
*Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have been changed.

155 East 38 Street
New York, NY 10016

Research My Research

Interests

functional neuroimaging of pharmacological activity, relationship of neural plasticity to the emergence of psychopathology

Research Summary

For many years, Dr. Brodie has maintained a close collaboration with Dr. Stephen Dewey and the PET group of Brookhaven National Laboratory. This effort has focused on the investigation of neurotransmitter interactions and their application to clinical issues. We use PET neuroimaging methods with pharmacological perturbations as probes and changes in binding of radioligands to specific neuroreceptors as outcome measures. We pair these human and non-human primate studies with microdialysis studies and behavioral observations as independent measures. With this strategy, we have established that the hallmark of any functioning psychoactive drug is chemical plasticity, expressed as neurotransmitter interactions, i.e. the ability to transmit and transduce a chemical signal to brain regions that may be distinguished in space and/or time. We are actively investigating the complexity of this accommodation with pharmacologic probes in non-human primates, normal controls and patient populations. Measurement of these interactions with PET is now an accepted method for examining pharmacological activity in vivo. Initially, we developed probes to investigate the ability of one neurotransmitter to modulate or be modulated by another functionally linked neurotransmitter system by using multiple radiotracers and pharmacologically specific challenges in the study of schizophrenia. These early studies have since evolved to encompass such areas as neuroleptic response and neurotransmitter stability. More recently our studies of GABAergic modulation of dopamine have led to the exciting findings that the suicide inhibitor of GABA transaminase, GVG, is an extraordinarily effective drug in blocking the use of virtually all drugs of abuse, including cocaine, nicotine, heroin, alcohol, methamphetamine and others. We are actively involved in the extension of these studies to human patients.

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
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Publications

  • Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement

    Santoro, Giovanni C; Carrion, Joseph; Patel, Krishna; Vilchez, Crystal; Veith, Jennifer; Brodie, Jonathan D; Dewey, Stephen L Santoro, Giovanni C; Carrion, Joseph; Patel, Krishna; Vilchez, Crystal; Veith, Jennifer; Brodie, Jonathan D; Dewey, Stephen L
    Neuropsychopharmacology. 2017 Apr 10. 42 (9): 1841-1849

  • A Novel Strategy for Attenuating Opioid Withdrawal in Neonates

    Santoro, Giovanni C; Shukla, Samarth; Patel, Krishna; Kaczmarzyk, Jakub; Agorastos, Stergiani; Scherrer, Sandra; Choi, Yoon Young; Veith, Christina; Carrion, Joseph; Silverman, Rebecca; Mullin, Danielle; Ahmed, Mohamed; Schiffer, Wynne K; Brodie, Jonathan D; Dewey, Stephen L Santoro, Giovanni C; Shukla, Samarth; Patel, Krishna; Kaczmarzyk, Jakub; Agorastos, Stergiani; Scherrer, Sandra; Choi, Yoon Young; Veith, Christina; Carrion, Joseph; Silverman, Rebecca; Mullin, Danielle; Ahmed, Mohamed; Schiffer, Wynne K; Brodie, Jonathan D; Dewey, Stephen L
    Journal of addiction research & therapy. 2016 Aug 11. 7 (4): ?-?

  • (1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent gamma-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction

    Pan, Yue; Gerasimov, Madina R; Kvist, Trine; Wellendorph, Petrine; Madsen, Karsten K; Pera, Elena; Lee, Hyunbeom; Schousboe, Arne; Chebib, Mary; Brauner-Osborne, Hans; Craft, Cheryl M; Brodie, Jonathan D; Schiffer, Wynne K; Dewey, Stephen L; Miller, Steven R; Silverman, Richard B Pan, Yue; Gerasimov, Madina R; Kvist, Trine; Wellendorph, Petrine; Madsen, Karsten K; Pera, Elena; Lee, Hyunbeom; Schousboe, Arne; Chebib, Mary; Brauner-Osborne, Hans; Craft, Cheryl M; Brodie, Jonathan D; Schiffer, Wynne K; Dewey, Stephen L; Miller, Steven R; Silverman, Richard B
    Journal of medicinal chemistry. 2012 Jan 12. 55 (1): 357-366

Read All Publications (134)